Search Results - "Vigneault, François"

Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells by Ouellet, Stéphane, Vigneault, François, Lessard, Maryse, Leclerc, Steeve, Drouin, Régen, Guérin, Sylvain L

“…The cyclin-dependent kinase inhibitor 1A (CDKN1A), also known as p21 (WAF1/CIP1) modulates cell cycle, apoptosis, senescence and differentiation via specific…”
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In Cellulo DNA Analysis: LMPCR Footprinting by Drouin, Régen, Bastien, Nathalie, Millau, Jean-François, Vigneault, François, Paradis, Isabelle

“…The in cellulo analysis of protein-DNA interactions and chromatin structure is very important to better understand the mechanisms involved in the regulation of…”
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Altered expression of the poly(ADP-ribosyl)ation enzymes in uveal melanoma and regulation of PARG gene expression by the transcription factor ERM by Molloy-Simard, Vanessa, St-Laurent, Jean-François, Vigneault, François, Gaudreault, Manon, Dargis, Natasha, Guérin, Marie-Christine, Leclerc, Steeve, Morcos, Mohib, Black, Daniel, Molgat, Yvonne, Bergeron, Dan, de Launoit, Yvan, Boudreau, François, Desnoyers, Serge, Guérin, Sylvain

“…Poly(ADP-ribosyl)ation is a reversible post-translational modification that requires the contribution of the enzymes poly(ADP-ribose) polymerase-1 (PARP-1) and…”
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Rescue of the Transcription Factors Sp1 and NFI in Human Skin Keratinocytes through a Feeder-Layer-Dependent Suppression of the Proteasome Activity by Duval, Céline, Gaudreault, Manon, Vigneault, François, Touzel-Deschênes, Lydia, Rochette, Patrick J., Masson-Gadais, Bénédicte, Germain, Lucie, Guérin, Sylvain L.

“…Co-culturing human skin keratinocytes along with a feeder layer has proven to considerably improve their proliferative properties by delaying massive induction…”
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Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data by Gupta, Namita T, Adams, Kristofor D, Briggs, Adrian W, Timberlake, Sonia C, Vigneault, Francois, Kleinstein, Steven H

“…Adaptive immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to…”
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Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping by Gidoni, Moriah, Snir, Omri, Peres, Ayelet, Polak, Pazit, Lindeman, Ida, Mikocziova, Ivana, Sarna, Vikas Kumar, Lundin, Knut E. A., Clouser, Christopher, Vigneault, Francois, Collins, Andrew M., Sollid, Ludvig M., Yaari, Gur

“…Analysis of antibody repertoires by high-throughput sequencing is of major importance in understanding adaptive immune responses. Our knowledge of variations…”
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Control of integrin genes expression in the eye by Vigneault, François, Zaniolo, Karine, Gaudreault, Manon, Gingras, Marie-Ève, Guérin, Sylvain L.

“…The ending race for sequencing the human genome has left the scientists faced with new challenges. Indeed, now that almost every human gene has been sequenced…”
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pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires by Vander Heiden, Jason A, Yaari, Gur, Uduman, Mohamed, Stern, Joel N H, O'Connor, Kevin C, Hafler, David A, Vigneault, Francois, Kleinstein, Steven H

“…Driven by dramatic technological improvements, large-scale characterization of lymphocyte receptor repertoires via high-throughput sequencing is now feasible…”
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Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing by Vander Heiden, Jason A, Stathopoulos, Panos, Zhou, Julian Q, Chen, Luan, Gilbert, Tamara J, Bolen, Christopher R, Barohn, Richard J, Dimachkie, Mazen M, Ciafaloni, Emma, Broering, Teresa J, Vigneault, Francois, Nowak, Richard J, Kleinstein, Steven H, O'Connor, Kevin C

“…Myasthenia gravis (MG) is a prototypical B cell-mediated autoimmune disease affecting 20-50 people per 100,000. The majority of patients fall into two…”
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Systematic identification of edited microRNAs in the human brain by Alon, Shahar, Mor, Eyal, Vigneault, Francois, Church, George M, Locatelli, Franco, Galeano, Federica, Gallo, Angela, Shomron, Noam, Eisenberg, Eli

“…Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA)…”
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B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes by Stern, Joel N H, Yaari, Gur, Vander Heiden, Jason A, Church, George, Donahue, William F, Hintzen, Rogier Q, Huttner, Anita J, Laman, Jon D, Nagra, Rashed M, Nylander, Alyssa, Pitt, David, Ramanan, Sriram, Siddiqui, Bilal A, Vigneault, Francois, Kleinstein, Steven H, Hafler, David A, O'Connor, Kevin C

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by autoimmune-mediated demyelination and…”
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Transcriptional Regulation of the Human α6 Integrin Gene by the Transcription Factor NFI during Corneal Wound Healing by Gaudreault, Manon, Vigneault, Franc¸ois, Gingras, Marie-Eve, Leclerc, Steeve, Carrier, Patrick, Germain, Lucie, Gue´rin, Sylvain L.

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Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity by Carter, Jason A, Preall, Jonathan B, Grigaityte, Kristina, Goldfless, Stephen J, Jeffery, Eric, Briggs, Adrian W, Vigneault, Francois, Atwal, Gurinder S

“…Although structural studies of individual T cell receptors (TCRs) have revealed important roles for both the α and β chain in directing MHC and antigen…”
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High-resolution antibody dynamics of vaccine-induced immune responses by Laserson, Uri, Vigneault, Francois, Gadala-Maria, Daniel, Yaari, Gur, Uduman, Mohamed, Heiden, Jason A. Vander, Kelton, William, Jung, Sang Taek, Liu, Yi, Laserson, Jonathan, Chari, Raj, Lee, Je-Hyuk, Bachelet, Ido, Hickey, Brendan, Lieberman-Aiden, Erez, Hanczaruk, Bozena, Simen, Birgitte B., Egholm, Michael, Koller, Daphne, Georgiou, George, Kleinstein, Steven H., Church, George M.

“…The adaptive immune system confers protection by generating a diverse repertoire of antibody receptors that are rapidly expanded and contracted in response to…”
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Optimal conditions and specific characteristics of Vent exo- DNA polymerase in ligation-mediated polymerase chain reaction protocols by Vigneault, François, Drouin, Régen

“…An optimized procedure for the ligation-mediated polymerase chain reaction (PCR) technique using Thermococcus litoralis exo- DNA polymerase (Vent exo-) was…”
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Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans by Gordin, Miri, Philip, Hagit, Zilberberg, Alona, Gidoni, Moriah, Margalit, Raanan, Clouser, Christopher, Adams, Kristofor, Vigneault, Francois, Cohen, Irun R, Yaari, Gur, Efroni, Sol

“…The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients…”
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Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data by Yaari, Gur, Vander Heiden, Jason A, Uduman, Mohamed, Gadala-Maria, Daniel, Gupta, Namita, Stern, Joel N H, O'Connor, Kevin C, Hafler, David A, Laserson, Uri, Vigneault, Francois, Kleinstein, Steven H

“…Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have…”
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Characterization of the survival motor neuron (SMN) promoter provides evidence for complex combinatorial regulation in undifferentiated and differentiated P19 cells by Rouget, Raphaël, Vigneault, François, Codio, Circé, Rochette, Camille, Paradis, Isabelle, Drouin, Régen, Simard, Louise R

“…There exist two SMN (survival motor neuron) genes in humans, the result of a 500 kb duplication in chromosome 5q13. Deletions/mutations in the SMN1 gene are…”
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Barcoding bias in high-throughput multiplex sequencing of miRNA by Alon, Shahar, Vigneault, Francois, Eminaga, Seda, Christodoulou, Danos C, Seidman, Jonathan G, Church, George M, Eisenberg, Eli

“…Second-generation sequencing is gradually becoming the method of choice for miRNA detection and expression profiling. Given the relatively small number of…”
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Antibody Repertoire Analysis of Hepatitis C Virus Infections Identifies Immune Signatures Associated With Spontaneous Clearance by Eliyahu, Sivan, Sharabi, Oz, Elmedvi, Shiri, Timor, Reut, Davidovich, Ateret, Vigneault, Francois, Clouser, Chris, Hope, Ronen, Nimer, Assy, Braun, Marius, Weiss, Yaacov Y, Polak, Pazit, Yaari, Gur, Gal-Tanamy, Meital

“…Hepatitis C virus (HCV) is a major public health concern, with over 70 million people infected worldwide, who are at risk for developing life-threatening liver…”
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