Search Results - "Vignali, Dario"

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups by Andrews, Lawrence P., Yano, Hiroshi, Vignali, Dario A. A.

“…Although immunotherapeutics targeting the inhibitory receptors (IRs) CTLA-4, PD-1 or PD-L1 have made substantial clinical progress in cancer, a considerable…”
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Co-stimulatory and Co-inhibitory Pathways in Autoimmunity by Zhang, Qianxia, Vignali, Dario A.A.

“…The immune system is guided by a series of checks and balances, a major component of which is a large array of co-stimulatory and co-inhibitory pathways that…”
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Interferon-γ: teammate or opponent in the tumour microenvironment? by Gocher, Angela M., Workman, Creg J., Vignali, Dario A. A.

“…Cancer immunotherapy offers substantive benefit to patients with various tumour types, in some cases leading to complete tumour clearance. However, many…”
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IL-12 family cytokines: immunological playmakers by Vignali, Dario A A, Kuchroo, Vijay K

“…The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these…”
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How regulatory T cells work by Vignali, Dario A. A, Collison, Lauren W, Workman, Creg J

“…Key Points Regulatory T (T Reg ) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases…”
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T Cell Exhaustion by Baessler, Andrew, Vignali, Dario A.A

“…T cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to…”
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LAG-3 as the third checkpoint inhibitor by Aggarwal, Vaishali, Workman, Creg J., Vignali, Dario A. A.

“…Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target,…”
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Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer by Cillo, Anthony R., Kürten, Cornelius H.L., Tabib, Tracy, Qi, Zengbiao, Onkar, Sayali, Wang, Ting, Liu, Angen, Duvvuri, Umamaheswar, Kim, Seungwon, Soose, Ryan J., Oesterreich, Steffi, Chen, Wei, Lafyatis, Robert, Bruno, Tullia C., Ferris, Robert L., Vignali, Dario A.A.

“…Head and neck squamous cell carcinoma (HNSCC) arises through exposure to environmental carcinogens or malignant transformation by human papillomavirus (HPV)…”
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The plasticity and stability of regulatory T cells by Sakaguchi, Shimon, Vignali, Dario A. A., Rudensky, Alexander Y., Niec, Rachel E., Waldmann, Herman

“…In this Viewpoint article, several experts share their thoughts on the plasticity and stability of regulatory T cells, discussing the recent advances in our…”
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LAG3 (CD223) as a cancer immunotherapy target by Andrews, Lawrence P., Marciscano, Ariel E., Drake, Charles G., Vignali, Dario A. A.

“…Summary Despite the impressive impact of CTLA4 and PD1‐PDL1‐targeted cancer immunotherapy, a large proportion of patients with many tumor types fail to…”
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Targeting regulatory T cells in tumors by Liu, Chang, Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing autoimmunity. However, they also represent a major barrier to…”
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The inhibitory cytokine IL-35 contributes to regulatory T-cell function by COLLISON, Lauren W, WORKMAN, Creg J, KUO, Timothy T, BOYD, Kelli, YAO WANG, VIGNALI, Kate M, CROSS, Richard, SEHY, David, BLUMBERG, Richard S, VIGNALI, Dario A. A

“…Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for…”
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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid by Watson, McLane J., Vignali, Paolo D. A., Mullett, Steven J., Overacre-Delgoffe, Abigail E., Peralta, Ronal M., Grebinoski, Stephanie, Menk, Ashley V., Rittenhouse, Natalie L., DePeaux, Kristin, Whetstone, Ryan D., Vignali, Dario A. A., Hand, Timothy W., Poholek, Amanda C., Morrison, Brett M., Rothstein, Jeffrey D., Wendell, Stacy G., Delgoffe, Greg M.

“…Regulatory T (T reg ) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment…”
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Type 1 diabetes: translating mechanistic observations into effective clinical outcomes by Herold, Kevan C., Vignali, Dario A. A., Cooke, Anne, Bluestone, Jeffrey A.

“…Key Points For more than 25 years, type 1 diabetes (T1D) has been recognized as an autoimmune disease. The mechanisms involve innate and adaptive immune…”
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Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape by WOO, Seng-Ryong, TURNIS, Meghan E, TANGSOMBATVISIT, Stephanie, GROSSO, Joseph F, NETTO, George, SMELTZER, Matthew P, CHAUX, Alcides, UTZ, Paul J, WORKMAN, Creg J, PARDOLL, Drew M, KORMAN, Alan J, DRAKE, Charles G, GOLDBERG, Monica V, VIGNALI, Dario A. A, BANKOTI, Jaishree, SELBY, Mark, NIRSCHL, Christopher J, BETTINI, Matthew L, GRAVANO, David M, VOGEL, Peter, LONG LIU, Chih

“…Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer. Among these inhibitory receptors, CTLA-4 (targeted clinically by…”
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Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion by Sawant, Deepali V., Yano, Hiroshi, Chikina, Maria, Zhang, Qianxia, Liao, Mengting, Liu, Chang, Callahan, Derrick J., Sun, Zhe, Sun, Tao, Tabib, Tracy, Pennathur, Arjun, Corry, David B., Luketich, James D., Lafyatis, Robert, Chen, Wei, Poholek, Amanda C., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T cells (T reg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T reg cells subvert beneficial…”
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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity by Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., John Wherry, E., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Robust CD8 + T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory…”
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Once a Treg, always a Treg? by Sawant, Deepali V., Vignali, Dario A. A.

“…Summary Regulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and…”
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Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them? by Visperas, Anabelle, Vignali, Dario A A

“…Regulatory T cells (Tregs) are critical regulators of peripheral immune tolerance. Treg insufficiency can lead to autoimmune disorders, including type 1…”
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Interleukin-35 Limits Anti-Tumor Immunity by Turnis, Meghan E., Sawant, Deepali V., Szymczak-Workman, Andrea L., Andrews, Lawrence P., Delgoffe, Greg M., Yano, Hiroshi, Beres, Amy J., Vogel, Peter, Workman, Creg J., Vignali, Dario A.A.

“…Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although Treg cell depletion enhances tumor rejection, the ensuing autoimmune…”
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