Search Results - "Vigli, Daniele"
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Treatment with the Bacterial Toxin CNF1 Selectively Rescues Cognitive and Brain Mitochondrial Deficits in a Female Mouse Model of Rett Syndrome Carrying a MeCP2-Null Mutation
Published in International journal of molecular sciences (23-06-2021)“…Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked gene and a major cause of intellectual disability in females. No cure…”
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Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice and Rescues the Hyperalgesia in a Mouse Model of Rett Syndrome
Published in Neuroscience (15-01-2021)“…•Chronic treatment with CBDA reduces pain sensitivity in wild type mice.•Low doses of CBDA rescue the thermal hyperalgesia of a Rett syndrome mouse model.•CBDA…”
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Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome
Published in Neuropharmacology (15-09-2018)“…Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioural and physiological symptoms. RTT is caused by mutations in the…”
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Rett syndrome before regression: A time window of overlooked opportunities for diagnosis and intervention
Published in Neuroscience and biobehavioral reviews (01-12-2019)“…•Early behavioral and physiological alterations occur in Rett syndrome (RTT) patients.•Studies on RTT rodent models disclosed the presence of early…”
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Maternal Immune Activation in Mice Only Partially Recapitulates the Autism Spectrum Disorders Symptomatology
Published in Neuroscience (01-10-2020)“…•Prenatal exposure to Poly I:C induces alterations in motor responses and in sensory gating, not in social responsiveness.•Prenatal exposure to Poly I:C…”
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Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome
Published in Neuropharmacology (15-07-2017)“…Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioral and physiological symptoms. Mutations in the methyl CpG binding…”
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Methyl-CpG binding protein 2 functional alterations provide vulnerability to develop behavioral and molecular features of post-traumatic stress disorder in male mice
Published in Neuropharmacology (01-12-2019)“…Post-traumatic stress disorder (PTSD) is a mental disorder characterized by symptoms of persistent anxiety arising after exposure to traumatic events. Stress…”
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Methyl‐CpG binding protein 2 dysfunction provides stress vulnerability with sex‐ and zygosity‐dependent outcomes
Published in The European journal of neuroscience (01-05-2022)“…Stress vulnerability is a critical factor for the development of trauma‐related disorders; however, its biological underpinnings are not clear. We demonstrated…”
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Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder
Published in Neuropharmacology (01-01-2019)“…Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause CDKL5 Deficiency Disorder (CDD), a rare neurodevelopmental syndrome characterized…”
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Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome
Published in Journal of neuropathology and experimental neurology (01-03-2021)“…Abstract Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked MECP2 gene, characterized by severe behavioral and…”
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HPLC Determination of Bioactive Sulfur Compounds, Amino Acids and Biogenic Amines in Biological Specimens
Published in Advances in experimental medicine and biology (2017)“…There is an increasing interest for analytical methods aimed to detect biological sulfur-containing amines, because of their involvement in human diseases and…”
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