Search Results - "Vietti Michelina, Sandra"

Novel RAF‐directed approaches to overcome current clinical limits and block the RAS/RAF node by Scardaci, Rossella, Berlinska, Ewa, Scaparone, Pietro, Vietti Michelina, Sandra, Garbo, Edoardo, Novello, Silvia, Santamaria, David, Ambrogio, Chiara

“…Mutations in the RAS–RAF–MEK–ERK pathway are frequent alterations in cancer and RASopathies, and while RAS oncogene activation alone affects 19% of all…”
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Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models by Puliga, Elisabetta, De Bellis, Chiara, Vietti Michelina, Sandra, Capeloa, Tania, Migliore, Cristina, Orrù, Claudia, Baiocchi, Gian Luca, De Manzoni, Giovanni, Pietrantonio, Filippo, Reddavid, Rossella, Fumagalli Romario, Uberto, Ambrogio, Chiara, Corso, Simona, Giordano, Silvia

“…Background Gastric cancer (GC) is the third leading cause of cancer-related death worldwide, with a poor prognosis for patients with advanced disease. Since…”
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RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade by Nokin, Marie-Julie, Mira, Alessia, Patrucco, Enrico, Ricciuti, Biagio, Cousin, Sophie, Soubeyran, Isabelle, San José, Sonia, Peirone, Serena, Caizzi, Livia, Vietti Michelina, Sandra, Bourdon, Aurelien, Wang, Xinan, Alvarez-Villanueva, Daniel, Martínez-Iniesta, María, Vidal, August, Rodrigues, Telmo, García-Macías, Carmen, Awad, Mark M., Nadal, Ernest, Villanueva, Alberto, Italiano, Antoine, Cereda, Matteo, Santamaría, David, Ambrogio, Chiara

“…Selective KRAS G12C inhibitors have been developed to covalently lock the oncogene in the inactive GDP-bound state. Two of these molecules, sotorasib and…”
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How to manage KRAS G12C-mutated advanced non-small-cell lung cancer by Ricciuti, Biagio, Mira, Alessia, Andrini, Elisa, Scaparone, Pietro, Michelina, Sandra Vietti, Pecci, Federica, Cantini, Luca, De Giglio, Andrea, Lamberti, Giuseppe, Ambrogio, Chiara, Metro, Giulio

“…Constitutive KRAS signalling drives tumorigenesis across several cancer types. In non-small-cell lung cancer (NSCLC) activating KRAS mutations occur in ~30% of…”
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The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer by Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve

“…The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or…”
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Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer by Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve

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Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer by Di Federico, Alessandro, Ricciotti, Ilaria, Favorito, Valentina, Michelina, Sandra Vietti, Scaparone, Pietro, Metro, Giulio, De Giglio, Andrea, Pecci, Federica, Lamberti, Giuseppe, Ambrogio, Chiara, Ricciuti, Biagio

“…Purpose of Review Although the recent development of direct KRAS G12C inhibitors (G12Ci) has improved outcomes in KRAS mutant cancers, responses occur only in…”
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Experimental variables determine the outcome of RAS-RAS interactions by Zhou, Zhiwei, Nguyen, Tra Ly, Li, Xingxiao, Poujol, Christel, Berlinska, Ewa, Michelina, Sandra Vietti, Kapp, Jonas N., Plückthun, Andreas, Winslow, Monte M., Ambrogio, Chiara, Shan, Yibing, Santamaría, David, Westover, Kenneth D.

“…RAS clustering at the cell membrane is critical to activate signaling in cells, but whether this clustering is mediated exclusively by its c-terminal…”
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