Search Results - "Vienna, E"

Heat therapy: Mechanistic underpinnings and applications to cardiovascular health by Brunt, Vienna E, Minson, Christopher T

“…Cardiovascular diseases (CVD) are the leading cause of death worldwide, and novel therapies are drastically needed to prevent or delay the onset of CVD in…”
Get full text

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans by Brunt, Vienna E., Gioscia-Ryan, Rachel A., Casso, Abigail G., VanDongen, Nicholas S., Ziemba, Brian P., Sapinsley, Zachary J., Richey, James J., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.

“…Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut…”
Get full text

Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans by Brunt, Vienna E., Howard, Matthew J., Francisco, Michael A., Ely, Brett R., Minson, Christopher T.

“…Key points A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular‐related and all‐cause mortality; however, the specific…”
Get full text

KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin by Brunt, Vienna E., Minson, Christopher T.

“…Key points •  The increased blood flow associated with local heating of the skin is ∼60% dependent on nitric oxide. The remaining ∼40% is unknown. • …”
Get full text

Keynote lecture: strategies for optimal cardiovascular aging by Seals, Douglas R, Brunt, Vienna E, Rossman, Matthew J

“…This review summarizes the opening keynote presentation overview of the American Physiological Society Conference on Cardiovascular Aging: New Frontiers and…”
Get more information

Untangling Complexity: Gut Microbiota, Metabolites, and Fiber Intake in Type 2 Diabetes by Greenberg, Nathan T, Brunt, Vienna E

Get full text

Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation by Brunt, Vienna E, Eymann, Taylor M, Francisco, Michael A, Howard, Matthew J, Minson, Christopher T

“…Passive heat therapy (repeated hot tub or sauna use) reduces cardiovascular risk, but its effects on the mechanisms underlying improvements in microvascular…”
Get full text

New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia by Choi, Patricia J, Brunt, Vienna E, Fujii, Naoto, Minson, Christopher T

“…Cutaneous hyperemia in response to rapid skin local heating to 42°C has been used extensively to assess microvascular function. However, the response is…”
Get full text

Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors by Brunt, Vienna E., Wiedenfeld‐Needham, Karen, Comrada, Lindan N., Minson, Christopher T.

“…Key Points Accumulating evidence indicates that passive heat therapy (chronic use of hot tubs or saunas) has widespread physiological benefits, including…”
Get full text

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging by Brunt, Vienna E., LaRocca, Thomas J., Bazzoni, Amy E., Sapinsley, Zachary J., Miyamoto-Ditmon, Jill, Gioscia-Ryan, Rachel A., Neilson, Andrew P., Link, Christopher D., Seals, Douglas R.

“…Aging is associated with declines in cognitive performance, which are mediated in part by neuroinflammation, characterized by astrocyte activation and higher…”
Get full text

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice by Brunt, Vienna E., Gioscia‐Ryan, Rachel A., Richey, James J., Zigler, Melanie C., Cuevas, Lauren M., Gonzalez, Antonio, Vázquez‐Baeza, Yoshiki, Battson, Micah L., Smithson, Andrew T., Gilley, Andrew D., Ackermann, Gail, Neilson, Andrew P., Weir, Tiffany, Davy, Kevin P., Knight, Rob, Seals, Douglas R.

“…Key points Age‐related arterial dysfunction, characterized by oxidative stress‐ and inflammation‐mediated endothelial dysfunction and arterial stiffening, is…”
Get full text

Attenuation of exaggerated blood pressure responses to exercise: a byproduct of improved vascular function with passive heat therapy? by Nguyen, Kathy H., Brunt, Vienna E.

Get full text

Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner by Brunt, Vienna E, Fujii, Naoto, Minson, Christopher T

“…Cutaneous acetylcholine (ACh)-mediated dilation is commonly used to assess microvascular function, but the mechanisms of dilation are poorly understood…”
Get full text

Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin by Clayton, Zachary S., Brunt, Vienna E., Hutton, David A., Casso, Abigail G., Ziemba, Brian P., Melov, Simon, Campisi, Judith, Seals, Douglas R.

“…Aortic stiffening is a major independent risk factor for cardiovascular diseases, kidney dysfunction, and cognitive impairment. Doxorubicin…”
Get full text

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans by Brunt, Vienna E., Casso, Abigail G., Gioscia-Ryan, Rachel A., Sapinsley, Zachary J., Ziemba, Brian P., Clayton, Zachary S., Bazzoni, Amy E., VanDongen, Nicholas S., Richey, James J., Hutton, David A., Zigler, Melanie C., Neilson, Andrew P., Davy, Kevin P., Seals, Douglas R.

“…Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase…”
Get full text

Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment by Clayton, Zachary S, Rossman, Matthew J, Mahoney, Sophia A, Venkatasubramanian, Ravinandan, Maurer, Grace S, Hutton, David A, VanDongen, Nicholas S, Greenberg, Nathan T, Longtine, Abigail G, Ludwig, Katelyn R, Brunt, Vienna E, LaRocca, Thomas J, Campisi, Judith, Melov, Simon, Seals, Douglas R

“…Here, we assessed the role of cellular senescence and the senescence associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial…”
Get full text

Acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans by Brunt, Vienna E, Jeckell, Andrew T, Ely, Brett R, Howard, Matthew J, Thijssen, Dick H J, Minson, Christopher T

“…Ischemia-reperfusion (I/R) injury is a primary cause of poor outcomes following ischemic cardiovascular events. We tested whether acute hot water immersion…”
Get more information

Preventing endothelial cell‐mediated muscle satellite cell dysfunction: a new hot topic? by Casso, Abigail G., Brunt, Vienna E.

Get full text

The gut microbiome as a modulator of arterial function and age-related arterial dysfunction by Longtine, Abigail G, Greenberg, Nathan T, Bernaldo de Quirós, Yara, Brunt, Vienna E

“…The arterial system is integral to the proper function of all other organs and tissues. Arterial function is impaired with aging, and arterial dysfunction…”
Get more information

No independent, but an interactive, role of calcium-activated potassium channels in human cutaneous active vasodilation by Brunt, Vienna E, Fujii, Naoto, Minson, Christopher T

“…In human cutaneous microvasculature, endothelium-derived hyperpolarizing factors (EDHFs) account for a large portion of vasodilation associated with local…”
Get full text