Search Results - "Vieira Sanseverino, Maria Teresa"

A New Strategy for the Old Challenge of Thalidomide: Systems Biology Prioritization of Potential Immunomodulatory Drug (IMiD)-Targeted Transcription Factors by Kowalski, Thayne Woycinck, Feira, Mariléa Furtado, Lord, Vinícius Oliveira, Gomes, Julia do Amaral, Giudicelli, Giovanna Câmara, Fraga, Lucas Rosa, Sanseverino, Maria Teresa Vieira, Recamonde-Mendoza, Mariana, Schuler-Faccini, Lavinia, Vianna, Fernanda Sales Luiz

“…Several molecular mechanisms of thalidomide embryopathy (TE) have been investigated, from anti-angiogenesis to oxidative stress to cereblon binding. Recently,…”
Get full text

The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis by Gomes, Julia do Amaral, Kowalski, Thayne Woycinck, Fraga, Lucas Rosa, Macedo, Gabriel S., Sanseverino, Maria Teresa Vieira, Schuler-Faccini, Lavínia, Vianna, Fernanda Sales Luiz

“…Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy. The complete understanding of the…”
Get full text

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation by Kowalski, Thayne Woycinck, Gomes, Julia do Amaral, Garcia, Gabriela Barreto Caldas, Fraga, Lucas Rosa, Paixao-Cortes, Vanessa Rodrigues, Recamonde-Mendoza, Mariana, Sanseverino, Maria Teresa Vieira, Schuler-Faccini, Lavinia, Vianna, Fernanda Sales Luiz

“…The Cereblon-CRL4 complex has been studied predominantly with regards to thalidomide treatment of multiple myeloma. Nevertheless, the role of Cereblon-CRL4 in…”
Get full text

Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010 by Kowalski, Thayne Woycinck, Sanseverino, Maria Teresa Vieira, Schuler-Faccini, Lavinia, Vianna, Fernanda Sales Luiz

“…Background Thalidomide is a known teratogen and it is estimated that more than ten thousand babies were affected by thalidomide embryopathy (TE), which is…”
Get full text

COVID-19 during pregnancy and adverse outcomes: Concerns and recommendations from The Brazilian Teratology Information Service by Vianna, Fernanda Sales Luiz, Fraga, Lucas Rosa, Abeche, Alberto Mantovani, Silva, André Anjos Da, Sanseverino, Maria Teresa Vieira, Schuler-Faccini, Lavinia

“…SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The…”
Get full text

Twin Peaks: A spatial and temporal study of twinning rates in Brazil by Cardoso-Dos-Santos, Augusto César, Boquett, Juliano, Oliveira, Marcelo Zagonel de, Callegari-Jacques, Sidia Maria, Barbian, Márcia Helena, Sanseverino, Maria Teresa Vieira, Matte, Ursula, Schuler-Faccini, Lavínia

“…Twin births are an important public health issue due to health complications for both mother and children. While it is known that contemporary factors have…”
Get full text

High-risk twin pregnancy: case report of an adolescent patient with cystic fibrosis and systemic lupus erythematosus by Sanseverino, Paula Baptista, Hoffmann, Anneliese, Machado, Sandra, Farias, Mariana, Michels, Marcus Silva, Sanseverino, Maria Teresa Vieira, Marostica, Paulo José Cauduro

“…We present the first case to our knowledge of a spontaneous twin pregnancy in a 16-year-old Caucasian patient with cystic fibrosis and systemic lupus…”
Get full text

The natural history of pregnancies with prenatal diagnosis of Trisomy 18 or Trisomy 13: Retrospective cases of a 23-year experience in a Brazilian public hospital by Duque, Julio Alejandro Peña, Ferreira, Charles Francisco, Zachia, Suzana de Azevedo, Sanseverino, Maria Teresa Vieira, Gus, Rejane, Magalhães, José Antônio de Azevedo

“…Trisomy 18 (T18) and trisomy 13 (T13) are polymalformative syndromes associated with a high rate of spontaneous abortions, intrauterine death, and short…”
Get full text

Prevalence of thrombophilia-associated genetic risk factors in blood donors of a regional hospital in southern Brazil by Dick-Guareschi, Jéssica, Fontana, Juliana Cristine, Sanseverino, Maria Teresa Vieira, Kubaski, Francyne, Sekine, Leo, Mesquita, Nanci Félix, Onsten, Tor Gunnar Hugo, Leistner-Segal, Sandra

“…Thromboembolic events occur due to an imbalance in the hemostasis and some factors associated with this condition can be inherited. In order to evaluate the…”
Get full text

Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil by Sales Luiz Vianna, Fernanda, de Oliveira, Marcelo Zagonel, Sanseverino, Maria Teresa Vieira, Morelo, Elaine Faria, de Lyra Rabello Neto, Dacio, Lopez-Camelo, Jorge, Camey, Suzi Alves, Schuler-Faccini, Lavinia

“…•More than 5million tablets of thalidomide were distributed in Brazil in previous years.•Cases of thalidomide embryopathy phenotype occur in clusters in…”
Get full text

Impact on pregnancies in south Brazil from the influenza A (H1N1) pandemic: cohort study by da Silva, André Anjos, Ranieri, Tani Maria Schilling, Torres, Fernanda Duarte, Vianna, Fernanda Sales Luiz, Paniz, Graziella Rangel, Sanseverino, Paula Baptista, Picon, Paulo Dornelles, de Azevedo, Pietro Baptista, Costa, Marta Haas, Schuler-Faccini, Lavinia, Sanseverino, Maria Teresa Vieira

“…The emergence of a new subtype of the influenza virus in 2009 generated interest in the international medical community, the media, and the general population…”
Get full text

Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil by Vianna, Fernanda Sales Luiz, Lopez-Camelo, Jorge S, Leite, Júlio César Louguercio, Sanseverino, Maria Teresa Vieira, Dutra, Maria da Graça, Castilla, Eduardo E, Schüler-Faccini, Lavínia

“…The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In…”
Get full text

From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America by Schüler-Faccini, Lavinia, Sanseverino, Maria Teresa Vieira, Abeche, Alberto Mantovani, Vianna, Fernanda Sales Luiz, Fraga, Lucas Rosa, Rocha, Anastacia Guimaraes, Silva, André Anjos da, Souza, Paulo Ricardo Assis de, Hilgert, Artur Hartmann, Barbosa, Camila Pocharski, Kauppinem, Caroline Grasso, Martins, Daniela Fernandes, Santos, Daniela Silva, Colpes, Gabriel Henrique, Ecco, Gabriela, Silva, Helena Margot Flores Soares da, Penteado, Louise Piva, Santos, Tatiane Dos

“…In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT…”
Get full text

Further characterization of microdeletion syndrome involving 2p15‐p16.1 by Félix, Têmis Maria, Petrin, Aline Lourenço, Sanseverino, Maria Teresa Vieira, Murray, Jeffrey C.

“…We report on a patient presenting with cognitive delay, prenatal and postnatal growth deficiency, microcephaly, ptosis of eyelids, high and broad nasal root,…”
Get full text

CNOT1 p.Arg535Cys variant in holoprosencephaly with late onset diabetes mellitus by Queiroz Júnior, Amaro Freire, Sanseverino, Maria Teresa Vieira, Collares, Marcus Vinicius Martins, Fornari, Adriana, Virmond, Luiza Amaral, Filho, João Bosco Oliveira, Artigalás, Osvaldo, Félix, Têmis Maria

“…Holoprosencephaly (HPE) results from a lack of cleavage of the prosencephalon. It has a complex etiology, resulting from chromosome abnormalities or single…”
Get full text

Thalidomide Analogs in Brazil: Concern About Teratogenesis by Vianna, Fernanda Sales Luiz, Sanseverino, Maria Teresa Vieira, Faccini, Lavinia Schüler

“…It has been more than 50 years since thalidomide was withdrawn from the world market due to its teratogenic potential. However, its widespread use around the…”
Get full text

Expression profiles of meiotic genes in male vs. female gonads and gametes: Insights into fertility issues by Rockenbach, Marília Körbes, Fraga, Lucas Rosa, Kowalski, Thayne Woycinck, Sanseverino, Maria Teresa Vieira

“…Gametes are specialized cells that, at fertilization, give rise to a totipotent zygote capable of generating an entire organism. Female and male germ cells…”
Get full text

Epileptic encephalopathy and atypical Rett syndrome with mutations in CDKL5: clinical and molecular characterization of two Brazilian patients by Ermel, Erica Leitão, Carneiro, Lauriane Caroline, Souza, Carolina Fischinger Moura de, Crippa, Ana Chrystina de Souza, Sanseverino, Maria Teresa Vieira, Raskin, Salmo

Get full text

Revealing the expression profile of genes that encode the Subcortical Maternal Complex in human reproductive failures by Rockenbach, Marília Körbes, Fraga, Lucas Rosa, Kowalski, Thayne Woycinck, Sanseverino, Maria Teresa Vieira

“…The Subcortical Maternal Complex (SCMC) is composed of maternally encoded proteins required for the early stages of embryo development. Here we aimed to…”
Get full text

Editorial: Teratogenesis: Experimental Models, Mechanisms and Clinical Findings in Humans by Fraga, Lucas Rosa, Vianna, Fernanda Sales Luiz, Del Campo, Miguel, Sanseverino, Maria Teresa Vieira, Schuler-Faccini, Lavínia

Get full text