Search Results - "Vieira Machado, Alexandre"

Dendritic cells, macrophages, NK and CD8 + T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B by Lucinda, Natália, Figueiredo, Maria Marta, Pessoa, Natália Lima, Santos, Beatriz Senra Álvares da Silva, Lima, Graciela Kunrath, Freitas, Arthur Molinari, Machado, Alexandre Magalhães Vieira, Kroon, Erna Geessien, Antonelli, Lis Ribeiro do Valle, Campos, Marco Antônio

“…Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also blindness and encephalitis. It was previously shown that the immune response against…”
Get full text

CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge by Pontes Ferreira, Camila, Cariste, Leonardo Moro, Ferri Moraschi, Barbara, Ferrarini Zanetti, Bianca, Won Han, Sang, Araki Ribeiro, Daniel, Vieira Machado, Alexandre, Lannes-Vieira, Joseli, Gazzinelli, Ricardo Tostes, Vasconcelos, José Ronnie Carvalho

“…CD8+ T lymphocytes play an important role in controlling infections by intracellular pathogens. Chemokines and their receptors are crucial for the migration of…”
Get full text

LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8 + T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection by Ferreira, Camila Pontes, Cariste, Leonardo Moro, Santos Virgílio, Fernando Dos, Moraschi, Barbara Ferri, Monteiro, Caroline Brandão, Vieira Machado, Alexandre M, Gazzinelli, Ricardo Tostes, Bruna-Romero, Oscar, Menin Ruiz, Pedro Luiz, Ribeiro, Daniel Araki, Lannes-Vieira, Joseli, Lopes, Marcela de Freitas, Rodrigues, Mauricio Martins, de Vasconcelos, José Ronnie Carvalho

“…Integrins mediate the lymphocyte migration into an infected tissue, and these cells are essential for controlling the multiplication of many intracellular…”
Get full text

A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy by Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Marques, Virgínia, da Silva, Andrea Alice, Caetano, Bráulia, Moreira, Otacilio Cruz, Machado, Alexandre Vieira, Bruna-Romero, Oscar, Rodrigues, Maurício Martins, Gazzinelli, Ricardo Tostes, Lannes-Vieira, Joseli

“…Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival…”
Get full text

Swine influenza A virus subtypes circulating in Brazilian commercial pig herds from 2012 to 2019 by Fraiha, Ana Luiza Soares, Matos, Ana Carolina Diniz, Cunha, João Luis Reis, Santos, Beatriz Senra Álvares da Silva, Peixoto, Maria Vitória Chaves, Oliveira, Anna Gabriella Guimarães, Galinari, Grazielle Cossenzo Florentino, Nascimento, Heloíza Irtes de Jesus, Guedes, Maria Isabel Maldonado Coelho, Machado, Alexandre de Magalhães Vieira, Costa, Erica Azevedo, Lobato, Zélia Inês Portela

“…The swine influenza A virus (SIAV) subtypes/lineages H1N1pdm09, H3N2, H1N2, and H1N1 of seasonal human origin are widespread in Brazilian swine herds. A…”
Get full text

Organotypic hippocampal culture model reveals differential responses to highly similar Zika virus isolates by Oliveira, Marina da Silva, Cassiano, Larissa Marcely Gomes, Pioline, Jeanne, de Carvalho, Ketyllen Reis Andrade, Salim, Anna Christina de Matos, Alves, Pedro Augusto, Fernandes, Gabriel da Rocha, Machado, Alexandre de Magalhães Vieira, Coimbra, Roney Santos

“…Zika virus (ZIKV) caused an outbreak in Brazil, in 2015, being associated to microcephaly. ZIKV has a strong neurotropism leading to death of infected cells in…”
Get full text

Vaccination using recombinants influenza and adenoviruses encoding amastigote surface protein-2 are highly effective on protection against Trypanosoma cruzi infection by Barbosa, Rafael Polidoro Alves, Filho, Bruno Galvão, Dos Santos, Luara Isabela, Junior, Policarpo Ademar Sales, Marques, Pedro Elias, Pereira, Rafaela Vaz Sousa, Cara, Denise Carmona, Bruña-Romero, Oscar, Rodrigues, Maurício Martins, Gazzinelli, Ricardo Tostes, Machado, Alexandre Vieira

“…In the present study we evaluated the protection raised by immunization with recombinant influenza viruses carrying sequences coding for polypeptides…”
Get full text

Mitochondrial DNA as a Possible Ligand for TLR9 in Irinotecan-induced Small Intestinal Mucositis by Ávila, Thiago Vinicius, Menezes-Garcia, Zélia, do Nascimento Arifa, Raquel Duque, Soriani, Frederico Marianetti, Machado, Alexandre de Magalhães Vieira, Teixeira, Mauro Martins, Fagundes, Caio Tavares, Souza, Daniele G.

“…Cancer chemotherapy and radiotherapy may result in mucositis characterized by stem cell damage and inflammation in the gastrointestinal tract. The molecular…”
Get full text

Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi by Soares, Milena Botelho, Rodrigues, Mauricio M., Bruna-Romero, Oscar, Machado, Alexandre Vieira, Vasconcelos, José Ronnie, Dominguez, Mariana Ribeiro, Ersching, Jonatan, Vasconcelos, Juliana Fraga, Oliveira, Gabriel M., Araújo, Adriano Fernando, Gazzinelli, Ricardo Tostes

“…In earlier studies, we reported that a heterologous prime-boost regimen using recombinant plasmid DNA followed by replication-defective adenovirus vector, both…”
Get full text

Recombinant viruses as tools to induce protective cellular immunity against infectious diseases by Rocha, Carolina Damas, Caetano, Braulia Costa, Machado, Alexandre Vieira, Bruna-Romero, Oscar

“…Infections by intracellular pathogens such as viruses, some bacteria and many parasites, are cleared in most cases after activation of specific T cellular…”
Get full text

A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine reprograms immune response and reverses chronic cardiomyopathy by Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Marques, Virginia, da Silva, Andrea Alice, Caetano, Braulia, Moreira, Otacilio Cruz, Machado, Alexandre Vieira, Bruna-Romero, Oscar, Rodrigues, Mauricio Martins, Gazzinelli, Ricardo Tostes, Lannes-Vieira, Joseli

“…Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival…”
Get full text

Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1(pdm09) vaccine by Giarola-Silva, Sarah, Coelho-dos-Reis, Jordana G.A., Mourão, Marina Moraes, Campi-Azevedo, Ana Carolina, Nakagaki Silva, Erick E., Luiza-Silva, Maria, Martins, Marina Angela, Silveira-Cassette, Amanda Cardoso de Oliveira, Batista, Maurício Azevedo, Peruhype-Magalhães, Vanessa, Antonelli, Lis Ribeiro do Valle, Leite Ribeiro, José Geraldo, Elói-Santos, Silvana Maria, Machado, Alexandre Vieira, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Araújo, Márcio Sobreira Silva

“…The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that…”
Get full text

A Human Type 5 Adenovirus-Based Trypanosoma cruzi Therapeutic Vaccine Re-programs Immune Response and Reverses Chronic Cardiomyopathy: e1004594 by Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Marques, Virgínia, Silva, Andrea Aliceda, Caetano, Bráulia, Moreira, Otacilio Cruz, Machado, Alexandre Vieira, Bruna-Romero, Oscar, Rodrigues, Maurício Martins, Gazzinelli, Ricardo Tostes, Lannes-Vieira, Joseli

“…Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival…”
Get full text

Protective immunity and safety of a genetically modified influenza virus vaccine by Barbosa, Rafael Polidoro Alves, Salgado, Ana Paula Carneiro, Garcia, Cristiana Couto, Filho, Bruno Galvão, Gonçalves, Ana Paula de Faria, Lima, Braulio Henrique Freire, Lopes, Gabriel Augusto Oliveira, Rachid, Milene Alvarenga, Peixoto, Andiara Cristina Cardoso, de Oliveira, Danilo Bretas, Ataíde, Marco Antônio, Zirke, Carla Aparecida, Cotrim, Tatiane Marques, Costa, Érica Azevedo, Almeida, Gabriel Magno de Freitas, Russo, Remo Castro, Gazzinelli, Ricardo Tostes, Machado, Alexandre de Magalhães Vieira

“…Recombinant influenza viruses are promising viral platforms to be used as antigen delivery vectors. To this aim, one of the most promising approaches consists…”
Get full text

CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge by Pontes Ferreira, Camila, Cariste, Leonardo Moro, Ferri Moraschi, Barbara, Ferrarini Zanetti, Bianca, Won Han, Sang, Araki Ribeiro, Daniel, Vieira Machado, Alexandre, Lannes-Vieira, Joseli, Gazzinelli, Ricardo Tostes, Vasconcelos, José Ronnie Carvalho

Get full text

Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5′ terminal sequence: Induction of heterospecific B and T cell responses in mice by Vieira Machado, Alexandre, Naffakh, Nadia, Gerbaud, Sylvie, van der Werf, Sylvie, Escriou, Nicolas

“…We generated novel recombinant influenza A viruses (vNA38) harboring dicistronic NA segments with an extended native 5′ terminal sequence of 70 nucleotides…”
Get full text

Expression of a foreign gene by stable recombinant influenza viruses harboring a dicistronic genomic segment with an internal promoter by Machado, Alexandre Vieira, Naffakh, Nadia, Werf, Sylvie van der, Escriou, Nicolas

“…Based on the observation that an internally located 3′ promoter sequence can be functional (R. Flick and G. Hobom, Virology, 1999, 262(1), 93–103), we…”
Get full text