Analysis of the normative conditions of oral health, depression and serotonin-transporter-linked promoter region polymorphisms in an elderly population

Aim: To investigate the association between depression, the normative conditions of oral health and serotonin‐transporter‐linked promoter region (5‐HTTLPR) polymorphisms in a community‐dwelling elderly sample. Methods: Elderly adults living in a community (n = 200) were submitted to an oral clinic...

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Published in:	Geriatrics & gerontology international Vol. 13; no. 1; pp. 98 - 106
Main Authors:	Mendes, Danilo Cangussu, Silva, Thiago Fonseca, Barros, Lucas de Oliveira, de Oliveira, Marcos Vinícius Macêdo, Vieira, Leonardo Tadeu, Haikal, Desirée Sant'Ana, Guimarães, André Luiz Sena, De Paula, Alfredo Maurício Batista
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01-01-2013 Blackwell Publishing Ltd
Subjects:	Aged Brazil - epidemiology Chi-Square Distribution Cross-Sectional Studies Dental health depression Depression - epidemiology Depression - genetics elderly people Female Genetics Genotype Geriatric Assessment Humans Mental depression Middle Aged Mouth Diseases - epidemiology Mouth Diseases - genetics normative conditions of oral health Older people Oral Health Poisson Distribution Polymorphism, Genetic Polymorphism, Restriction Fragment Length Prevalence Psychometrics Serotonin Plasma Membrane Transport Proteins - genetics serotonin-transporter-linked promoter region polymorphism Surveys and Questionnaires Brazil
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Summary:	Aim: To investigate the association between depression, the normative conditions of oral health and serotonin‐transporter‐linked promoter region (5‐HTTLPR) polymorphisms in a community‐dwelling elderly sample. Methods: Elderly adults living in a community (n = 200) were submitted to an oral clinical examination. Depression was assessed using the 15‐item Geriatric Depression Scale. The 5‐HTTLPR was analyzed by polymerase chain reaction‐restriction fragment length polymorphism. Associations between the biomarkers and clinical covariates were assessed by bivariate and multivariate statistical tests. Statistical significance was set at P < 0.05. Results: The prevalence of dental caries, periodontal disease, edentulism and oral mucosal lesions was 51.2%, 20.8%, 58.0% and 21.5%, respectively. The prevalence of depression was 21.5%. A higher frequency of the S allele was recorded in older individuals with depression (P = 0.017). The present findings showed no significant association between depression and the normative conditions of oral health. The observed allelic polymorphisms were 44% S and 56% L, respectively. Genotypic variants were 33.5% LL, 45.0% SL and 21.5% SS. Individuals carrying the SS genotype showed a significantly high prevalence of periodontal disease (prevalence ratio = 3.077, CI 95% = 1.008–9.393, P = 0.048). Conclusion: The present findings suggest that depressive community‐dwelling older individuals did not show any association with alterations of oral health normative conditions. However, the SS genotypic polymorphic variant of 5‐HTTLPR seems to contribute to the occurrence of periodontal disease in the elderly. Geriatr Gerontol Int 2013; 13: 98–106.
Bibliography:	istex:C82FE89342ACFDD80D3746B32486C4ADF6837624 ArticleID:GGI867 ark:/67375/WNG-5FH854KH-L ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1444-1586 1447-0594
DOI:	10.1111/j.1447-0594.2012.00867.x