Milk Fermented by Lactobacillus paracasei NCC 2461 (ST11) Modulates the Immune Response and Microbiota to Exert its Protective Effects Against Salmonella typhimurium Infection in Mice

Milk Fermented by Lactobacillus paracasei NCC 2461 (ST11) Modulates the Immune Response and Microbiota to Exert its Protective Effects Against Salmonella typhimurium Infection in Mice

Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probioti...

Full description

Saved in:
Bibliographic Details
Published in:Probiotics and antimicrobial proteins Vol. 12; no. 4; pp. 1398 - 1408
Main Authors: Acurcio, Leonardo Borges, Wuyts, Sander, de Cicco Sandes, Sávio Henrique, Sant’anna, Felipe Machado, Pedroso, Silvia Helena Sousa Pietra, Bastos, Rafael Wesley, dos Reis, Diego Carlos, Vieira, Andréa Faria, Cassali, Geovanni Dantas, Lebeer, Sarah, de Souza, Marcelo Resende, Nicoli, Jacques Robert
Format: Journal Article
Language:English
Published: New York Springer US 01-12-2020
Springer Nature B.V
Subjects:
Animal models
Applied Microbiology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fermented milk products
Gene expression
Ileum
Immune response
Infections
Inflammation
Interleukin 17
Interleukin 6
Intestine
Lactobacillus paracasei
Microbiology
Microbiota
Milk
Nutrition
Probiotics
Protein Science
Salmonella
Spleen
Tumor necrosis factor-α
γ-Interferon
Probiotic
Protective effect
Fermented milk
Salmonella
Lactobacillus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probiotic effects of milk fermented by L. paracasei ST11 (administered through fermented milk) in a Salmonella typhimurium infection model in BALB/c mice. We observed in this murine model that the applied probiotic conferred protective effects against S . typhimurium infection, since its administration reduced mortality, weight loss, translocation to target organs (liver and spleen) and ileum injury. Moreover, a reduction in the mRNA expression of pro-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-17 in animals that received the probiotic before challenge was observed. Additionally, the ileum microbiota was better preserved in these animals. The present study highlights a multifactorial protective aspect of this commercial probiotic strain against a common gastrointestinal pathogen.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-020-09634-x