Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report

Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report

Pleuroparenchymal fibroelastosis (PPFE) is a rare and recently described distinct pattern of lung apical fibrosis involving the upper lobe parenchyma and pleural dome. PPFE has definable and reproducible clinical, radiological and histopathological criteria, which allowed its classification as an in...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and clinical oncology Vol. 16; no. 3
Main Authors: Vieira, Ana Claudia Rodrigues, Ferra, Joana Raquel Monteiro, De Carvalho, Joana Sofia Vicente, Melo, Natalia, Mota, Patricia Caetano, Bastos, Helder Novais E, Pereira, Jose Miguel, Moura, Conceicao Souto, Morais, Antonio
Format: Journal Article
Language:English
Published: Athens Spandidos Publications 01-03-2022
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects:
Biopsy
Cancer
Carbon monoxide
Case reports
Chemotherapy
Comorbidity
Development and progression
Drugs
Dyspnea
Lung diseases
Lymphomas
Oncology
Patients
Pneumonia
Radiation therapy
Transplants & implants
Portugal
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pleuroparenchymal fibroelastosis (PPFE) is a rare and recently described distinct pattern of lung apical fibrosis involving the upper lobe parenchyma and pleural dome. PPFE has definable and reproducible clinical, radiological and histopathological criteria, which allowed its classification as an independent interstitial lung disease. Several factors have been associated with PPFE, such as chemotherapy, especially with alkylating agents. The authors present a case of a 34-year-old female with previous history of Hodgkin lymphoma treated with first line chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine). The patient had no other known comorbidities or relevant exposure to lung irritants. A total of 2 years after completing cancer treatment, the patient developed clinical and radiological features of PPFE. Given their previous history of malignancy, a biopsy of the lesion was obtained, which confirmed the diagnosis of PPFE. The authors present this case to raise awareness of this disease and to demonstrate that PPFE can develop months to years following chemotherapy treatment. Moreover, to date, none of these chemotherapy agents have been associated with the development of PPFE.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2022.2504