Search Results - "Viegas Junior, Claudio"

Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors by Freitas, Thamires R., Danuello, Amanda, Viegas Júnior, Claudio, Bolzani, Vanderlan S., Pivatto, Marcos

“…Rationale Piperidine alkaloids from Senna spectabilis constitute a rare class of natural products with several biological activities. However, the absence of…”
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Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp by Gontijo, Vanessa Silva, de Souza, Thiago Corrêa, Rosa, Isael Aparecido, Soares, Marisi Gomes, da Silva, Marcelo Aparecido, Vilegas, Wagner, Viegas, Cláudio, dos Santos, Marcelo Henrique

“…► Four antioxidant phenolic compounds were isolated from Garcinia brasiliensis. ► Was isolated a new glycosylated biflavonone:…”
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Molecular hybridization: a useful tool in the design of new drug prototypes by Viegas-Junior, Cláudio, Danuello, Amanda, da Silva Bolzani, Vanderlan, Barreiro, Eliezer J, Fraga, Carlos Alberto Manssour

“…Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances…”
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Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis by Lacerda, Rosimeire Borges Moreira, Freitas, Thamires Rodrigues, Martins, Mário Machado, Teixeira, Thaise Lara, da Silva, Cláudio Vieira, Candido, Pamela Aparecida, Oliveira, Ronaldo Junio de, Júnior, Claudio Viegas, Bolzani, Vanderlan da Silva, Danuello, Amanda, Pivatto, Marcos

“…Natural alkaloid (–)-3-O-acetylcassine (green) with leishmanicidal activity, isolated from Senna spectabilis flowers. [Display omitted] •The novel alkaloid…”
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Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin by de Souza, Aline Aparecida, de Andrade, Débora Martins, Siqueira, Fábio da Silva, Di Iorio, Juliana Fortes, Veloso, Marcia Paranho, Coelho, Camila de Morais, Viegas Junior, Claudio, Gontijo, Vanessa Silva, dos Santos, Marcelo Henrique, Meneghetti, Maria Cecília Zorél, Nader, Helena Bonciani, Tersariol, Ivarne Luis dos Santos, Juliano, Luiz, Juliano, Maria Aparecida, Judice, Wagner Alves de Souza

“…Garcinia brasiliensis is a species native to the Amazon forest. The white mucilaginous pulp is used in folk medicine as a wound healing agent and for peptic…”
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The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy by Duarte Filho, Luiz Antonio Miranda de Souza, Yanaguibashi Leal, Cintia Emi, Bodet, Pierre-Edouard, Beserra de Alencar Filho, Edilson, Almeida, Jackson Roberto Guedes da Silva, Porta Zapata, Manon, Achour, Oussama, Groult, Hugo, Gouveia Veloso, Carlos Arthur, Viegas Júnior, Claudio, Bourgougnon, Nathalie, Picot, Laurent

“…Brown seaweeds of the genus represent a rich source of natural antiviral products. In this study, a hydroalcoholic extract (FCHE) was found to inhibit 74.2 ±…”
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Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression by Pereira, Rodrigo Machado, Ferreira-Silva, Guilherme Álvaro, Pivatto, Marcos, Santos, Luciana de Ávila, Bolzani, Vanderlan da Silva, Chagas de Paula, Daniela Aparecida, Oliveira, Jaqueline Carvalho de, Viegas Júnior, Cláudio, Ionta, Marisa

“…Cancer is one of the most critical problems of public health in the world and one of the main challenges for medicine in this century. Unfortunately, most…”
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In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae) by de Castro, Andreísa Teixeira, Castro, Aline Pereira, Silva, Matheus Siqueira, de Souza, Isabella Maria Monteiro, Martins-Souza, Raquel Lopes, Chagas-Paula, Daniela Aparecida, Coelho, Luiz Felipe Leomil, da Silva Bolzani, Vanderlan, Pivatto, Marcos, Viegas, Claudio, Marques, Marcos José

“…[Display omitted] In this work, we present the in vitro schistosomicidal activity evaluation of the most active dichloromethane fraction (FDm) (ED50=83.5μg/mL)…”
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Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes by de Almeida, Letícia, Alves, Karina Ferreira, Maciel-Rezende, Claudia Mara, Jesus, Larissa de Oliveira Passos, Pires, Francieli Ribeiro, Junior, Claudio Viegas, Izidoro, Mario Augusto, Júdice, Wagner Alves de Souza, dos Santos, Marcelo Henrique, Marques, Marcos José

“…Abstract The leishmanicidal potential of benzophenones has been described, some of them highlighting their potential as cysteine protease inhibitors…”
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Antimalarial Activity of Piperidine Alkaloids from Senna spectabilis and Semisynthetic Derivatives by Pivatto, Marcos, Baccini, Luciene R., Sharma, Abhinay, Nakabashi, Myna, Danuello, Amanda, Viegas Júnior, Claudio, Garcia, Celia R. S., Bolzani, Vanderlan S.

“…In our continuing work looking for new anti-infective lead compounds from Brazilian biomes, the two known piperidine alkaloids ( - )-cassine and ( -…”
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Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives by Gontijo, Vanessa Silva, Judice, Wagner A.S., Codonho, Barbara, Pereira, Ivan Oliveira, Assis, Diego Magno, Januário, Jaqueline Pereira, Caroselli, Elide E., Juliano, Maria Aparecida, de Carvalho Dosatti, Amanda, Marques, Marcos José, Junior, Claudio Viegas, Henrique dos Santos, Marcelo

“…The natural biflavonoids morelloflavone-4‴-O-β-d-glycosyl (1), (±)-fukugiside (2) and morelloflavone (3) were isolated from the ethyl acetate extract (EAEE) of…”
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(-)-7-hydroxycassine: a new 2,6-dialkylpiperidin-3-ol alkaloid and other constituents isolated from flowers and fruits of Senna spectabilis (Fabaceae) by Viegas Junior, Cláudio, Pivatto, Marcos, Rezende, Amanda de, Hamerski, Lidilhone, Silva, Dulce Helena Siqueira, Bolzani, Vanderlan da Silva

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Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones by Maciel-Rezende, Claudia Mara, de Almeida, Letícia, Costa, Éderson D’Martin, Pires, Francieli Ribeiro, Alves, Karina Ferreira, Junior, Cláudio Viegas, Dias, Danielle Ferreira, Doriguetto, Antônio Carlos, Marques, Marcos José, dos Santos, Marcelo Henrique

“…Nine O-alkyl and O-prenyl derivatives were synthesized from commercial 2,4-dihydroxybenzophenone, 4,e4,4′-dihydroxybenzophenone and were evaluated for their…”
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An in silico Study of Benzophenone Derivatives as Potential Non-Competitive Inhibitors of Trypanosoma cruzi and Leishmania Amazonensis Cysteine Proteinases by Freitas, Poliany, Castilho, Thiago, de Almeida, Leticia, Maciel‑Rezende, Claudia, Costa, Luciano, Viegas Junior, Claudio, Marques, Marcos, dos Santos, Marcelo, da Silveira, Nelson

“…This study investigates the mechanisms of interaction between benzophenone derivatives and cruzain and Llacys1 (the protein expressed by cysteine protease gene…”
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Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia by Viegas Junior, Cláudio, Rezende, Amanda de, Silva, Dulce Helena Siqueira, Castro-Gambôa, Ian, Bolzani, Vanderlan da Silva, Barreiro, Eliezer J., Miranda, Ana Luisa Palhares de, Alexandre-Moreira, Magna Suzana, Young, Maria Cláudia Marx

“…Species of Cassia are widely distributed in tropical and subtropical regions throughout the world, and have been extensively investigated chemically and…”
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Morelloflavone and its semisynthetic derivatives as potential novel inhibitors of cysteine and serine proteases by Vanessa, Silva Gontijo, Jaqueline, Pereira Januario, Wagner, Alves de Souza Judice, Alyne, Alexandrino Antunes, Ingridy, Ribeiro Cabral, Diego, Magno Assis, Maria, Aparecida Juliano, Ihosvany, Camps, Marcos, Jose Marques, Claudio, Viegas Junior, Marcelo, Henrique dos Santos

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Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer by Viegas Junior, Cláudio, Bolzani, Vanderlan da Silva, Furlan, Maysa, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J.

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The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fd L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy by Duarte Filho, Luiz Antonio Miranda de Souza, Yanaguibashi Leal, Cintia Emi, Bodet, Pierre-Edouard, Beserra de Alencar Filho, Edilson, Almeida, Jackson Roberto Guedes da Silva, Porta Zapata, Manon, Achour, Oussama, Groult, Hugo, Gouveia Veloso, Carlos Arthur, Viegas Júnior, Claudio, Bourgougnon, Nathalie, Picot, Laurent

“…Brown seaweeds of the Fucus genus represent a rich source of natural antiviral products. In this study, a Fucus ceranoides hydroalcoholic extract (FCHE) was…”
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(–)-7-Hydroxycassine: a New 2,6-Dialkylpiperidin-3-ol Alkaloid and other Constituents Isolated from Flowers and Fruits of Senna spectabilis (Fabaceae) by Viegas Junior, Cláudio, Pivatto, Marcos, Rezende, Amanda de, Hamerski, Lidilhone, Silva, Dulce Helena Siqueira, Bolzani, Vanderlan da Silva

“…The phytochemical study of flowers and green fruits of Senna spectabilis furnished a new substituted 2,6-dialkylpiperidin-3-ol alkaloid, named…”
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Terpenos com atividade inseticida: uma alternativa para o controle químico de insetos by Viegas Júnior, Cláudio

“…Many substances from different sources have been used by men for decades to control insects. After the 2nd World War, the use of inorganic compounds have…”
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