Search Results - "Viegas, Sandra C."

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway by Malecki, Michal, Viegas, Sandra C, Carneiro, Tiago, Golik, Pawel, Dressaire, Clémentine, Ferreira, Miguel G, Arraiano, Cecília M

“…The final step of cytoplasmic mRNA degradation proceeds in either a 5′‐3′ direction catalysed by Xrn1 or in a 3′‐5′ direction catalysed by the exosome…”
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critical role of RNA processing and degradation in the control of gene expression by Arraiano, Cecília M, Andrade, José M, Domingues, Susana, Guinote, Inês B, Malecki, Michal, Matos, Rute G, Moreira, Ricardo N, Pobre, Vânia, Reis, Filipa P, Saramago, Margarida, Silva, Inês J, Viegas, Sandra C

“…The continuous degradation and synthesis of prokaryotic mRNAs not only give rise to the metabolic changes that are required as cells grow and divide but also…”
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Pseudomonas putida KT2440 is naturally endowed to withstand industrial‐scale stress conditions by Ankenbauer, Andreas, Schäfer, Richard A., Viegas, Sandra C., Pobre, Vânia, Voß, Björn, Arraiano, Cecília M., Takors, Ralf

“…Summary Pseudomonas putida is recognized as a very promising strain for industrial application due to its high redox capacity and frequently observed tolerance…”
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The Virulence of Salmonella enterica Serovar Typhimurium in the Insect Model Galleria mellonella Is Impaired by Mutations in RNase E and RNase III by VIEGAS, Sandra C, MIL-HOMENS, Dalila, FIALHO, Arsénio M, ARRAIANO, Cecília M

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The role of RNases in the regulation of small RNAs by Saramago, Margarida, Bárria, Cátia, dos Santos, Ricardo F, Silva, Inês J, Pobre, Vânia, Domingues, Susana, Andrade, José M, Viegas, Sandra C, Arraiano, Cecília M

“…Highlights • Bacterial RNases control sRNA-mediated negative and positive regulation. • RNase III can simultaneously cleave the sRNAs and their respective mRNA…”
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Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism by Towler, Benjamin P, Pashler, Amy L, Haime, Hope J, Przybyl, Katarzyna M, Viegas, Sandra C, Matos, Rute G, Morley, Simon J, Arraiano, Cecilia M, Newbury, Sarah F

“…Dis3L2 is a highly conserved 3'-5' exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms' tumour of the kidney. Using…”
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Regulation of the small regulatory RNA MicA by ribonuclease III: a target-dependent pathway by Viegas, Sandra C, Silva, Inês J, Saramago, Margarida, Domingues, Susana, Arraiano, Cecília M

“…MicA is a trans-encoded small non-coding RNA, which downregulates porin-expression in stationary-phase. In this work, we focus on the role of endoribonucleases…”
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How hydrolytic exoribonucleases impact human disease: Two sides of the same story by Costa, Susana M., Saramago, Margarida, Matos, Rute G., Arraiano, Cecília M., Viegas, Sandra C.

“…RNAs are extremely important molecules inside the cell, which perform many different functions. For example, messenger RNAs, transfer RNAs and ribosomal RNAs…”
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The world of ribonucleases from pseudomonads: a short trip through the main features and singularities by Apura, Patrícia, Gonçalves, Luis G., Viegas, Sandra C., Arraiano, Cecília M.

“…Summary The development of synthetic biology has brought an unprecedented increase in the number molecular tools applicable into a microbial chassis. The…”
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Developing New Tools to Fight Human Pathogens: A Journey through the Advances in RNA Technologies by Costa, Vanessa G, Costa, Susana M, Saramago, Margarida, Cunha, Marta V, Arraiano, Cecília M, Viegas, Sandra C, Matos, Rute G

“…A long scientific journey has led to prominent technological advances in the RNA field, and several new types of molecules have been discovered, from…”
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The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs by Saramago, Margarida, Costa, Vanessa G, Souza, Caio S, Bárria, Cátia, Domingues, Susana, Viegas, Sandra C, Lousa, Diana, Soares, Cláudio M, Arraiano, Cecília M, Matos, Rute G

“…The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the scientific community. Vaccination is a crucial weapon to fight this virus;…”
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Synergies between RNA degradation and trans-translation in Streptococcus pneumoniae: cross regulation and co-transcription of RNase R and SmpB by Moreira, Ricardo N, Domingues, Susana, Viegas, Sandra C, Amblar, Mónica, Arraiano, Cecília M

“…Ribonuclease R (RNase R) is an exoribonuclease that recognizes and degrades a wide range of RNA molecules. It is a stress-induced protein shown to be important…”
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New targets for drug design: importance of nsp14/nsp10 complex formation for the 3’‐5’ exoribonucleolytic activity on SARS‐CoV‐2 by Saramago, Margarida, Bárria, Cátia, Costa, Vanessa G., Souza, Caio S., Viegas, Sandra C., Domingues, Susana, Lousa, Diana, Soares, Cláudio M., Arraiano, Cecília M., Matos, Rute G.

“…SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The understanding of fundamental aspects of this virus is of extreme…”
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Reprogramming bacteria with RNA regulators by Apura, Patrícia, Domingues, Susana, Viegas, Sandra C, Arraiano, Cecília M

“…The revolution of genomics and growth of systems biology urged the creation of synthetic biology, an engineering discipline aiming at recreating and…”
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Ribonucleases control distinct traits of Pseudomonas putida lifestyle by Apura, Patrícia, Lorenzo, Víctor, Arraiano, Cecília M., Martínez‐García, Esteban, Viegas, Sandra C.

“…Summary The role of archetypal ribonucleases (RNases) in the physiology and stress endurance of the soil bacterium and metabolic engineering platform…”
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Prediction of novel non-coding RNAs relevant for the growth of Pseudomonas putida in a bioreactor by Pobre, Vânia, Graça-Lopes, Gil, Saramago, Margarida, Ankenbauer, Andreas, Takors, Ralf, Arraiano, Cecília M, Viegas, Sandra C

“…is a micro-organism with great potential for industry due to its stress-endurance traits and easy manipulation of the metabolism. However, optimization is…”
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Tailor-made sRNAs: a plasmid tool to control the expression of target mRNAs in Pseudomonas putida by Apura, Patrícia, Saramago, Margarida, Peregrina, Alexandra, Viegas, Sandra C., Carvalho, Sandra M., Saraiva, Lígia M., Arraiano, Cecília M., Domingues, Susana

“…Pseudomonas putida is a highly attractive production system for industrial needs. However, for its improvement as a biocatalyst at the industrial level,…”
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A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells by da Costa, Paulo J., Menezes, Juliane, Saramago, Margarida, García-Moreno, Juan F., Santos, Hugo A., Gama-Carvalho, Margarida, Arraiano, Cecília M., Viegas, Sandra C., Romão, Luísa

“…The nonsense-mediated decay (NMD) pathway selectively degrades mRNAs carrying a premature translation-termination codon but also regulates the abundance of a…”
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Surprises in the 3′‐end: ‘U’ can decide too by Viegas, Sandra C, Silva, Inês J, Apura, Patricia, Matos, Rute G, Arraiano, Cecilia M

“…RNA molecules are subjected to post‐transcriptional modifications that might determine their maturation, activity, localization and stability. These…”
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Characterization of the role of ribonucleases in Salmonella small RNA decay by Viegas, Sandra C, Pfeiffer, Verena, Sittka, Alexandra, Silva, Inês J, Vogel, Jörg, Arraiano, Cecília M

“…In pathogenic bacteria, a large number of sRNAs coordinate adaptation to stress and expression of virulence genes. To better understand the turnover of…”
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