Combined treatment including postoperative chemotherapy in lung cancer patients

The results of a cooperative randomized study performed in Poland, Bulgaria, Czechoslovakia, Hungary, and the Soviet Union on the treatment of lung cancer patients are presented. Three hundred and sixty patients were treated only surgically, 360 patients received combined therapy. Adjuvant chemother...

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Bibliographic Details
Published in:	Neoplasma Vol. 35; no. 3; p. 351
Main Authors:	Trakhtenberg, A Kh, Zakharchenkov, A V, Zhiglov, M A, Glagolev, A N, Kovalev, V N, Amiraliev, M A, Barchuk, A S, Malay, E F, Vidyak, I V, Grigoryeva, S P
Format:	Journal Article
Language:	English
Published:	Slovakia 1988
Subjects:	Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - surgery Combined Modality Therapy Cyclophosphamide - administration & dosage Female Fluorouracil - administration & dosage Humans Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - surgery Lymphatic Metastasis Male Methotrexate - administration & dosage Middle Aged Neoplasm Staging Random Allocation Statistics as Topic
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Summary:	The results of a cooperative randomized study performed in Poland, Bulgaria, Czechoslovakia, Hungary, and the Soviet Union on the treatment of lung cancer patients are presented. Three hundred and sixty patients were treated only surgically, 360 patients received combined therapy. Adjuvant chemotherapy was performed using 3 preparations (cyclophosphane, methotrexate, 5-fluorouracil) within 2-3 weeks after operation (first course) followed by another 3 courses at intervals of 8-9 weeks. The combined therapy increased the 5-year survival rate of patients with Stage III squamous cell carcinoma with thoracic lymph node metastases. Better results were achieved when 3-4 courses of adjuvant chemotherapy were performed. In patients with Stage I-II squamous cell carcinoma of the lung without regional lymph node metastases the used regimen of combined therapy had no significant effect.
ISSN:	0028-2685