Search Results - "Vidwans, Smruti J"

Genomically Driven Tumors and Actionability across Histologies: BRAF-Mutant Cancers as a Paradigm by Turski, Michelle L, Vidwans, Smruti J, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Subbiah, Vivek, Rodon, Jordi, Kurzrock, Razelle

“…The diagnosis, classification, and management of cancer are traditionally dictated by the site of tumor origin, for example, breast or lung, and by specific…”
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A novel classification of lung cancer into molecular subtypes by West, Lisandra, Vidwans, Smruti J, Campbell, Nicholas P, Shrager, Jeff, Simon, George R, Bueno, Raphael, Dennis, Phillip A, Otterson, Gregory A, Salgia, Ravi

“…The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy…”
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A melanoma molecular disease model by Vidwans, Smruti J, Flaherty, Keith T, Fisher, David E, Tenenbaum, Jay M, Travers, Michael D, Shrager, Jeff

“…While advanced melanoma remains one of the most challenging cancers, recent developments in our understanding of the molecular drivers of this disease have…”
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A framework for genomic biomarker actionability and its use in clinical decision making by Vidwans, Smruti J, Turski, Michelle L, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Subbiah, Vivek, Rodon, Jordi, Kurzrock, Razelle

“…The increasing scope and availability of genetic testing options for patients suffering from cancer has raised questions about how to use results of molecular…”
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Cycling through development in Drosophila and other metazoa by Vidwans, Smruti J, Su, Tin Tin

“…The cell-division cycle is an orchestrated sequence of events that results in the duplication of a cell. In metazoa, cell proliferation is regulated in…”
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Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle by Vidwans, Smruti J., Wong, Mei Lie, O'Farrell, Patrick H.

“…Centrosome duplication is marked by discrete changes in centriole structure that occur in lock-step with cell cycle transitions. We show that mitotic…”
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Sister Chromatids Fail to Separate during an Induced Endoreplication Cycle in Drosophila Embryos by Vidwans, Smruti J, DiGregorio, Paul J, Shermoen, Antony W, Foat, Barrett, Iwasa, Janet, Yakubovich, Nikita, O'Farrell, Patrick H

“…When mitosis is bypassed, as in some cancer cells or in natural endocycles, sister chromosomes remain paired and produce four-stranded diplochromosomes or…”
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Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome by Agarwal, Rishi, Liebe, Sarah, Turski, Michelle L, Vidwans, Smruti J, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Rodon, Jordi, Kurzrock, Razelle, Subbiah, Vivek

“…Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome are cancer syndromes which affect multiple organs and lead to significant decline in quality…”
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Targeted therapy for hereditary cancer syndromes: hereditary breast and ovarian cancer syndrome, Lynch syndrome, familial adenomatous polyposis, and Li-Fraumeni syndrome by Agarwal, Rishi, Liebe, Sarah, Turski, Michelle L, Vidwans, Smruti J, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Rodon, Jordi, Kurzrock, Razelle, Subbiah, Vivek

“…Cancer genetics has rapidly evolved in the last two decades. Understanding and exploring the several genetic pathways in the cancer cell is the foundation of…”
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Targeted therapy for hereditary cancer syndromes: neurofibromatosis type 1, neurofibromatosis type 2, and Gorlin syndrome by Agarwal, Rishi, Liebe, Sarah, Turski, Michelle L, Vidwans, Smruti J, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Rodon, Jordi, Kurzrock, Razelle, Subbiah, Vivek

“…Hereditary cancer syndromes are well known in the oncology community, typically affecting children, adolescents, and young adults and thereby resulting in…”
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Targeted therapy for genetic cancer syndromes: Fanconi anemia, medullary thyroid cancer, tuberous sclerosis, and RASopathies by Agarwal, Rishi, Liebe, Sarah, Turski, Michelle L, Vidwans, Smruti J, Janku, Filip, Garrido-Laguna, Ignacio, Munoz, Javier, Schwab, Richard, Rodon, Jordi, Kurzrock, Razelle, Subbiah, Vivek

“…With the advent of genomics-based treatment in recent years, the use of targeted therapies in the treatment of various malignancies has increased…”
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Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation by Vidwans, Smruti J, Wong, Mei Lie, O'Farrell, Patrick H

“…The centriole, organizer of the centrosome, duplicates by assembling a unique daughter identical to itself in overall organization and length. The centriole is…”
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DNA defects target the centrosome by Vidwans, Smruti J, Su, Tin Tin

“…When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to…”
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Cytoskeleton: Centrosom-in absentia by Vidwans, Smruti J, O'Farrell, Patrick H

“…Recent results challenge long-held assumptions that centrosomes are essential organizers of mitotic spindles, but suggest that they couple spindle behavior…”
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Possible role for the essential GTP-binding protein Obg in regulating the initiation of sporulation in Bacillus subtilis by Vidwans, S J, Ireton, K, Grossman, A D

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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