Search Results - "Victoria, Ivan"
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Testing Physical Scenarios for the Reflection Features of Type-1 AGNs using XMM-Newton and NuSTAR Simultaneous Observations
Published in The Astrophysical journal (01-09-2023)“…Above ∼3 keV, the X-ray spectrum of active galactic nuclei (AGNs) is characterized by the intrinsic continuum and Compton reflection features. For type-1 AGNs,…”
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AGN Torus Detectability at Submillimeter Wavelengths: What to Expect from ALMA Continuum Data
Published in The Astrophysical journal (10-02-2019)“…Dust close (∼few pc) to the accretion disk in active galactic nuclei (AGNs) is key to understanding many of their observational signatures, and it is key to…”
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Determinants of activity and efficacy of anti-PD1/PD-L1 therapy in patients with advanced solid tumors recruited in a clinical trials unit: a longitudinal prospective biomarker-based study
Published in Cancer Immunology, Immunotherapy (01-06-2023)“…Immune-checkpoint inhibitors (ICI) have revolutionized the therapeutic landscape of cancer. However, optimal patient selection is still an unmet need…”
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Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma
Published in Muscle & nerve (01-12-2017)“…ABSTRACT Introduction Pembrolizumab, a monoclonal antibody directed against the immune checkpoint programmed cell death‐1 receptor (PD‐1), has improved…”
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716 Phase 2 study of the HER2-targeting TLR7/8 immune stimulating antibody conjugate (ISAC) BDC-1001 monotherapy +/- nivolumab in patients with HER2+ colorectal, endometrial, or gastroesophageal cancer
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundDespite advances made in management of patients with HER2-driven solid tumors, unmet need remains for novel approaches to improve patient outcomes…”
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Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data
Published in European journal of medical research (07-10-2024)“…Over the past decade, numerous studies on potential factors contributing to ventilation-induced lung injury have been carried out. Mechanical power has been…”
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Immune-Related Gene Expression Profiling After PD-1 Blockade in Non-Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but most patients exhibit partial or…”
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The Complex Infrared Dust Continuum Emission of NGC 1068: Ground-based N- and Q-band Spectroscopy and New Radiative Transfer Models
Published in The Astrophysical journal (01-02-2022)“…Thanks to ground-based infrared and submillimeter observations the study of the dusty torus of nearby active galactic nuclei has greatly advanced in the last…”
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Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
Published in British journal of cancer (05-12-2017)“…Background: Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and…”
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The influence of treatment sequence in the prognostic value of TMPRSS2‐ERG as biomarker of taxane resistance in castration‐resistant prostate cancer
Published in International journal of cancer (01-10-2019)“…TMPRSS2‐ERG expression in blood has been correlated with low docetaxel benefit in metastatic castration‐resistant prostate cancer (mCRPC). This multicenter…”
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Glutamine and Cholesterol Plasma Levels and Clinical Outcomes of Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Taxanes
Published in Cancers (01-10-2021)“…Altered metabolism is a hallmark of cancer. Malignant cells metabolise glutamine to fulfil their metabolic needs. In prostate cancer, androgen receptor…”
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Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer
Published in Frontiers in oncology (02-11-2020)“…The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition…”
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Ipilimumab after progression on anti-PD-1 treatment in advanced melanoma
Published in Future oncology (London, England) (01-12-2016)“…While both efficacy and safety of anti-PD-1 agents seem to be independent of previous treatment with anti-CTLA-4, limited data exist of efficacy and toxicity…”
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Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer
Published in Cells (Basel, Switzerland) (14-01-2020)“…Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether…”
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Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation
Published in World journal of gastroenterology : WJG (14-11-2014)“…AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant…”
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Molecular characterization of advanced non-small cell lung cancer patients by cfDNA analysis: experience from routine laboratory practice
Published in Journal of thoracic disease (01-03-2021)“…Analysis of circulating free DNA (cfDNA) by the real-time PCR cobas EGFR Mutation Test v2 (cobas EGFR Test) is a diagnostic approach used in clinical practice…”
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Towards an observationally motivated AGN dusty torus model – I. Dust chemical composition from the modelling of Spitzer spectra
Published in Monthly notices of the Royal Astronomical Society (13-05-2024)“…Spectral energy distribution (SED) fitting is one of the most commonly used techniques to study the dust properties in active galactic nuclei (AGN). Works…”
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Pembrolizumab in a BRAF-mutant metastatic melanoma patient following a severe immune-related adverse event with ipilimumab
Published in Immunotherapy (01-06-2016)“…Currently, limited data exist on the safety of pembrolizumab in patients with metastatic melanoma who have developed severe immune-related adverse events…”
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A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours
Published in European journal of cancer (1990) (01-03-2021)“…ABTL0812 is an autophagy inducer that promotes cancer cell death by activation of cytotoxic autophagy selectively in tumour cells. ABTL0812 induces endoplasmic…”
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