Search Results - "Victor, Tieu"

A MEGA RNA-editing tool by Tieu, Victor

“…In this Tools of the Trade article, Victor Tieu describes the development of MEGA, a platform that exploits the RNA-targeting capability of CRISPR–Cas13d and…”
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c-Jun overexpression in CAR T cells induces exhaustion resistance by Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, de Bourcy, Charles F. A., Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard Y., Mackall, Crystal L.

“…Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer 1 – 3 , but dysfunction due to T cell exhaustion…”
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A Versatile Crispr/CAS13D Platform for Multiplexed Transcriptomic Regulation and Metabolic Engineering in Primary Human T Cells by Tieu, Victor

“…Decades of research in synthetic biology and immunology have endowed us with the blueprints for a new therapeutic modality: the engineered immune cell…”
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Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery by Miller, Jason B, Kos, Petra, Tieu, Victor, Zhou, Kejin, Siegwart, Daniel J

“…Lipid nanoparticles (LNPs) currently comprise the most effective carrier class for the delivery of small RNAs. Among lipid carriers, charge-unbalanced lipids…”
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Enhanced T cell effector activity by targeting the Mediator kinase module by Freitas, Katherine A, Belk, Julia A, Sotillo, Elena, Quinn, Patrick J, Ramello, Maria C, Malipatlolla, Meena, Daniel, Bence, Sandor, Katalin, Klysz, Dorota, Bjelajac, Jeremy, Xu, Peng, Burdsall, Kylie A, Tieu, Victor, Duong, Vandon T, Donovan, Micah G, Weber, Evan W, Chang, Howard Y, Majzner, Robbie G, Espinosa, Joaquin M, Satpathy, Ansuman T, Mackall, Crystal L

“…T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted…”
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A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells by Tieu, Victor, Sotillo, Elena, Bjelajac, Jeremy R, Chen, Crystal, Malipatlolla, Meena, Guerrero, Justin A, Xu, Peng, Quinn, Patrick J, Fisher, Chris, Klysz, Dorota, Mackall, Crystal L, Qi, Lei S

“…CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy,…”
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The systematic design and biophysical evaluation of cationic sulfonamide aminolipids for siRNA delivery by Jason, Miller, Victor, Tieu, Daniel, Siegwart

“…Abstract only…”
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Towards a biohybrid sensing platform built on impedance-based bacterial flagellar motor tachometry by Zajdel, Tom J., Walczak, Alexander N., Sengupta, Debleena, Tieu, Victor, Rad, Behzad, Maharbiz, Michel M.

“…Though the chemotaxis sensing system of Escherichia coli is known to approach fundamental biosensing limits, few attempts have been made to co-opt it as the…”
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