Search Results - "Victor, Sofia M Benedict"

Preclinical Optimization of gp120 Entry Antagonists as anti-HIV‑1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation by Curreli, Francesca, Ahmed, Shahad, Benedict Victor, Sofia M, Iusupov, Ildar R, Belov, Dmitry S, Markov, Pavel O, Kurkin, Alexander V, Altieri, Andrea, Debnath, Asim K

“…We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-14189 (Ref1), which…”
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Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors by Curreli, Francesca, Ahmed, Shahad, Benedict Victor, Sofia M., Iusupov, Ildar R., Spiridonov, Evgeny A., Belov, Dmitry S., Altieri, Andrea, Kurkin, Alexander V., Debnath, Asim K.

“…[Display omitted] We presented our continuing stride to optimize the second-generation NBD entry antagonist targeted to the Phe43 cavity of HIV-1 gp120. We…”
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Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV by Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M Benedict, Debnath, Asim K

“…Combination antiretroviral therapy (cART) is successful in maintaining undetectable levels of HIV in the blood; however, the persistence of latent HIV…”
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