Search Results - "Vicky Y. Lin"

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21 by Inagaki, Takeshi, Lin, Vicky Y., Goetz, Regina, Mohammadi, Moosa, Mangelsdorf, David J., Kliewer, Steven A.

“…Starvation blocks the actions of growth hormone (GH) and inhibits growth through mechanisms that are not well understood. In this report, we demonstrate that…”
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Forskolin Stimulates Estrogen Receptor (ER) α Transcriptional Activity and Protects ER from Degradation by Distinct Mechanisms by Tsai, Houng-Wei, Lin, Vicky Y., Shupnik, Margaret A.

“…Estradiol action is mediated by estrogen receptors (ERs), a and ß. Estradiol binding initiates ER-mediated transcription and ER degradation, the latter of…”
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FGF21 contributes to neuroendocrine control of female reproduction by Owen, Bryn M, Bookout, Angie L, Ding, Xunshan, Lin, Vicky Y, Atkin, Stan D, Gautron, Laurent, Kliewer, Steven A, Mangelsdorf, David J

“…Fibroblast growth factor 21 (FGF21) is a cytokine synthesized and released by the liver, muscle and fat and acts both locally and systemically to regulate…”
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Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors by Rodriguez, Bertha L, Huang, Jiawei, Gibson, Laura, Fradette, Jared J, Chen, Hung-I H, Koyano, Kikuye, Cortez, Czrina, Li, Betty, Ho, Carmence, Ashique, Amir M, Lin, Vicky Y, Crawley, Suzanne, Roda, Julie M, Chen, Peirong, Fan, Bin, Kim, Jeong, Sissons, James, Sitrin, Jonathan, Kaplan, Daniel D, Gibbons, Don L, Rivera, Lee B

“…We recently reported that resistance to PD-1 blockade in a refractory lung cancer-derived model involved increased collagen deposition and the collagen-binding…”
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The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells by Paavola, Kevin J, Roda, Julie M, Lin, Vicky Y, Chen, Peirong, O'Hollaren, Kyle P, Ventura, Richard, Crawley, Suzanne C, Li, Betty, Chen, Hung-I H, Malmersjö, Seth, Sharkov, Nikolai A, Horner, Geoffrey, Guo, Wei, Kutach, Alan K, Mondal, Kalyani, Zhang, Zhen, Lichtman, Joshua S, Song, Christina, Rivera, Lee B, Liu, Wenhui, Luo, Jian, Wang, Yan, Solloway, Mark J, Allan, Bernard B, Kekatpure, Avantika, Starck, Shelley R, Haldankar, Raj, Fan, Bin, Chu, Chun, Tang, Jie, Molgora, Martina, Colonna, Marco, Kaplan, Daniel D, Hsu, Jer-Yuan

“…Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly…”
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ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms by Tian, Jane, Ashique, Amir M, Weeks, Sabrina, Lan, Tian, Yang, Hong, Chen, Hung-I Harry, Song, Christina, Koyano, Kikuye, Mondal, Kalyani, Tsai, Daniel, Cheung, Isla, Moshrefi, Mehrdad, Kekatpure, Avantika, Fan, Bin, Li, Betty, Qurashi, Samir, Rocha, Lauren, Aguayo, Jonathan, Rodgers, Col, Meza, Marchelle, Heeke, Darren, Medfisch, Sara M, Chu, Chun, Starck, Shelley, Basak, Nandini Pal, Sankaran, Satish, Malhotra, Mohit, Crawley, Suzanne, Tran, Thomas-Toan, Duey, Dana Y, Ho, Carmence, Mikaelian, Igor, Liu, Wenhui, Rivera, Lee B, Huang, Jiawei, Paavola, Kevin J, O'Hollaren, Kyle, Blum, Lisa K, Lin, Vicky Y, Chen, Peirong, Iyer, Anjushree, He, Sisi, Roda, Julie M, Wang, Yan, Sissons, James, Kutach, Alan K, Kaplan, Daniel D, Stone, Geoffrey W

“…Solid tumors are dense three-dimensional (3D) multicellular structures that enable efficient receptor-ligand trans interactions via close cell-cell contact…”
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Ligand-Independent Activation of Pituitary ER: Dependence on PKA-Stimulated Pathways by Schreihofer, Derek A, Resnick, Eileen M, Lin, Vicky Y, Shupnik, Margaret A

“…In pituitary and other target tissues, estrogen acts through ERs, which are ligand-activated nuclear transcription factors. ERs can also be activated by…”
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Truncated Estrogen Receptor Product-1 Stimulates Estrogen Receptor α Transcriptional Activity by Titration of Repressor Proteins by Lin, Vicky Y., Resnick, Eileen M., Shupnik, Margaret A.

“…The truncated estrogen receptor product-1 (TERP-1, or TERP) is a pituitary-specific isoform of estrogen receptor α (ERα), and its expression is regulated by…”
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Preclinical Characterization of NGM936, a Novel Bispecific T Cell Engager Targeting ILT3 for the Treatment of Acute Myeloid Leukemia with Monocytic Differentiation by Lin, Vicky Y, Iyer, Anjushree, Akama, Keith, Cheng, Rujin, Yang, Hong, Aguayo, Jonathan, Li, Betty, Kutach, Alan K, Tang, Jie, Kaplan, Daniel, Roda, Julie M

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Abstract LB156: Preclinical evaluation of NGM707, a novel anti-ILT2/anti-ILT4 dual antagonist monoclonal antibody by Mondal, Kalyani, Song, Christina, Tian, Jane, Ho, Carmence, Rivera, Lee B., Huang, Jiawei, Chen, Peirong, Crawley, Suzanne, Lin, Vicky Y., Sitrin, Jonathan, Roda, Julie M., Shen, David, Tian, Hui, Wang, Yan, Kutach, Alan, Kim, Jeong, Sissons, James, Kaplan, Daniel D., Stone, Geoffrey W.

“…Background: Myeloid immune suppression in the tumor microenvironment is known to contribute to tumor immune evasion. ILT2 (aka LILRB1) and ILT4 (aka LILRB2)…”
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Abstract LB216: Pre-clinical characterization of NGM831, an ILT3 antagonist antibody for the treatment of solid tumors by Chen, Peirong, Crawley, Suzanne C., Lin, Vicky Y., Kapoor, Varun, Paavola, Kevin J., Chen, Hung-I, Lichtman, Joshua S., Li, Betty, Mondal, Kalyani, Kutach, Alan K., Wang, Yan, Kaplan, Daniel D., Roda, Julie M.

“…Suppressive myeloid cells inhibit antitumor immunity by preventing T cell responses. Immunoglobulin-like transcript 3 (ILT3, also known as LILRB4) is highly…”
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Truncated Estrogen Receptor Product-1 Stimulates Estrogen Receptor α Transcriptional Activity by Titration of Repressor Proteins by Vicky Y. Lin, Eileen M. Resnick, Margaret A. Shupnik

“…The truncated estrogen receptor product-1 (TERP-1, or TERP) is a pituitary-specific isoform of estrogen receptor α (ERα), and its expression is regulated by…”
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