Search Results - "Vickery, Christopher M."

Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage by Beck, Katy E, Thorne, Leigh, Lockey, Richard, Vickery, Christopher M, Terry, Linda A, Bujdoso, Raymond, Spiropoulos, John

“…According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can…”
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Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy by Vickery, Christopher M, Lockey, Richard, Holder, Thomas M, Thorne, Leigh, Beck, Katy E, Wilson, Christina, Denyer, Margaret, Sheehan, John, Marsh, Sarah, Webb, Paul R, Dexter, Ian, Norman, Angela, Popescu, Emma, Schneider, Amanda, Holden, Paul, Griffiths, Peter C, Plater, Jane M, Dagleish, Mark P, Martin, Stuart, Telling, Glenn C, Simmons, Marion M, Spiropoulos, John

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The interpretation of disease phenotypes to identify TSE strains following murine bioassay: characterisation of classical scrapie by Beck, Katy E, Vickery, Christopher M, Lockey, Richard, Holder, Thomas, Thorne, Leigh, Terry, Linda A, Denyer, Margaret, Webb, Paul, Simmons, Marion M, Spiropoulos, John

“…Mouse bioassay can be readily employed for strain typing of naturally occurring transmissible spongiform encephalopathy cases. Classical scrapie strains have…”
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Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile by Beck, Katy E., Sallis, Rosemary E., Lockey, Richard, Vickery, Christopher M., Béringue, Vincent, Laude, Hubert, Holder, Thomas M., Thorne, Leigh, Terry, Linda A., Tout, Anna C., Jayasena, Dhanushka, Griffiths, Peter C., Cawthraw, Saira, Ellis, Richard, Balkema-Buschmann, Anne, Groschup, Martin H., Simmons, Marion M., Spiropoulos, John

“…Two cases of unusual transmissible spongiform encephalopathy (TSE) were diagnosed on the same farm in ARQ/ARQ PrP sheep showing attributes of both bovine…”
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The interpretation of disease phenotypes to identify TSE strains in mice: characterisation of BSE using PrPSc distribution patterns in the brain by Corda, Erica, Beck, Katy E, Sallis, Rosemary E, Vickery, Christopher M, Denyer, Margaret, Webb, Paul R, Bellworthy, Susan J, Spencer, Yvonne I, Simmons, Marion M, Spiropoulos, John

“…In individual animals affected by transmissible spongiform encephalopathies, different disease phenotypes can be identified which are attributed to different…”
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Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results by GONZALEZ, Lorenzo, THORNE, Leigh, JEFFREY, Martin, MARTIN, Stuart, SPIROPOULOS, John, BECK, Katy E, LOCKEY, Richard W, VICKERY, Christopher M, HOLDER, Thomas, TERRY, Linda

“…It is widely accepted that abnormal forms of the prion protein (PrP) are the best surrogate marker for the infectious agent of prion diseases and, in practice,…”
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Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time by Maddison, Ben C, Spiropoulos, John, Vickery, Christopher M, Lockey, Richard, Owen, Jonathan P, Bishop, Keith, Baker, Claire A, Gough, Kevin C

“…Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and…”
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Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time by Maddison, Ben C, Spiropoulos, John, Vickery, Christopher M, Lockey, Richard, Owen, Jonathan P, Bishop, Keith, Baker, Claire A, Gough, Kevin C

“…AbstractOvine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months…”
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Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes by Vickery, Christopher M., Beck, Katy E., Simmons, Marion M., Hawkins, Stephen A. C., Spiropoulos, John

“…Summary Mouse‐adapted transmissible spongiform encephalopathy (TSE) strains are routinely distinguished based on reproducible disease characteristics in a…”
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Overexpression of chimaeric murine/ovine PrP (A136H154Q171) in transgenic mice facilitates transmission and differentiation of ruminant prions by Griffiths, Peter C, Plater, Jane M, Chave, Alun, Jayasena, Dhanushka, Tout, Anna C, Rice, Paul B, Vickery, Christopher M, Spiropoulos, John, Stack, Michael J, Windl, Otto

“…Development of transgenic mouse models expressing heterologous prion protein (PrP) has facilitated and advanced in vivo studies of prion diseases affecting…”
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Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie by Corda, Erica, Thorne, Leigh, Beck, Katy E, Lockey, Richard, Green, Robert B, Vickery, Christopher M, Holder, Thomas M, Terry, Linda A, Simmons, Marion M, Spiropoulos, John

“…Scrapie and bovine spongiform encephalopathy (BSE) are transmissible spongiform encephalopathies (TSEs) which naturally affect small and large ruminants…”
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Strain Typing of Classical Scrapie by Transgenic Mouse Bioassay Using Protein Misfolding Cyclic Amplification to Replace Primary Passage. e57851 by Beck, Katy E, Thorne, Leigh, Lockey, Richard, Vickery, Christopher M, Terry, Linda A, Bujdoso, Raymond, Spiropoulos, John

“…According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can…”
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