Search Results - "Vickers, Steven P."

TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding by Dedic, Nina, Wang, Lien, Hajos-Korcsok, Eva, Hecksher-Sørensen, Jacob, Roostalu, Urmas, Vickers, Steven P., Wu, Serena, Anacker, Christoph, Synan, Colleen, Jones, Philip G., Milanovic, Snezana, Hopkins, Seth C., Bristow, Linda J., Koblan, Kenneth S.

“…Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients. Recent…”
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Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake by GARDINER, James V, BATAVELJIC, Attia, EBLING, Francis J. P, VICKERS, Steven P, CHEETHAM, Sharon, GHATEI, Mohammad A, BLOOM, Stephen R, DHILLO, Waljit S, PATEL, Neekhil A, BEWICK, Gavin A, ROY, Debabrata, CAMPBELL, Daniel, GREENWOOD, Hannah C, MURPHY, Kevin G, HAMEED, Saira, JETHWA, Preeti H

“…Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake James V. Gardiner 1 , Attia Bataveljic 1 , Neekhil A. Patel 1 , Gavin A…”
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Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine by Vickers, Steven P, Goddard, Simon, Brammer, Richard J, Hutson, Peter H, Heal, David J

“…Freely-fed, female, rats were trained in a two-lever, delay-discounting task: one lever delivered a single chocolate-flavoured pellet immediately and the other…”
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Effects of lisdexamfetamine in a rat model of binge-eating by Vickers, Steven P, Hackett, David, Murray, Fraser, Hutson, Peter H, Heal, David J

“…Binge-eating disorder is a common psychiatric disorder affecting ~2% of adults. Binge-eating was initiated in freely-fed, lean, adult, female rats by giving…”
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Effects of the DPP-4 inhibitor, linagliptin, in diet-induced obese rats: a comparison in naive and exenatide-treated animals by Vickers, Steven P, Cheetham, Sharon C, Birmingham, Gareth D, Rowley, Helen L, Headland, Katie R, Dickinson, Keith, Grempler, Rolf, Hocher, Berthold, Mark, Michael, Klein, Thomas

“…To assess the chronic effect of the DPP-4 inhibitor, linagliptin, alone, in combination with exenatide, and during exenatide withdrawal, in diet-induced obese…”
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The utility of animal models to evaluate novel anti‐obesity agents by Vickers, Steven P, Jackson, Helen C, Cheetham, Sharon C

“…The global incidence of obesity continues to rise and is a major driver of morbidity and mortality through cardiovascular and cerebrovascular diseases. Animal…”
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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model by Fromont, Christophe, Atzori, Alessio, Kaur, Divneet, Hashmi, Lubna, Greco, Graziella, Cabanillas, Alejandro, Nguyen, Huy Van, Jones, D. Heulyn, Garzón, Miguel, Varela, Ana, Stevenson, Brett, Iacobini, Greg P, Lenoir, Marc, Rajesh, Sundaresan, Box, Clare, Kumar, Jitendra, Grant, Paige, Novitskaya, Vera, Morgan, Juliet, Sorrell, Fiona J, Redondo, Clara, Kramer, Andreas, Harris, C. John, Leighton, Brendan, Vickers, Steven P, Cheetham, Sharon C, Kenyon, Colin, Grabowska, Anna M, Overduin, Michael, Berditchevski, Fedor, Weston, Chris J, Knapp, Stefan, Fischer, Peter M, Butterworth, Sam

“…Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most…”
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Lisdexamfetamine reduces the compulsive and perseverative behaviour of binge-eating rats in a novel food reward/punished responding conflict model by Heal, David J, Goddard, Simon, Brammer, Richard J, Hutson, Peter H, Vickers, Steven P

“…Compulsive and perseverative behaviour in binge-eating, female, Wistar rats was investigated in a novel food reward/punished responding conflict model. Rats…”
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Animal models to explore the effects of CNS drugs on food intake and energy expenditure by Vickers, Steven P., Clifton, Peter G.

“…Obesity has reached epidemic proportions globally with an increasing incidence not just in Western cultures but also Mexico, Brazil, China and parts of Africa…”
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Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats by Jones, Robert B., Vickers, Steven P., Cheetham, Sharon C., Headland, Katie R., Mark, Michael, Klein, Thomas

“…The effects of the dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, alone and in combination with voglibose or exendin-4, on glycaemic control and body…”
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Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet by Vickers, Steven P, Cheetham, Sharon C, Headland, Katie R, Dickinson, Keith, Grempler, Rolf, Mayoux, Eric, Mark, Michael, Klein, Thomas

“…The present study assessed the potential of the sodium glucose-linked transporter (SGLT)-2 inhibitor empagliflozin to decrease body weight when administered…”
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Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors by VICKERS, Steven P, DOURISH, Colin T, KENNETT, Guy A

“…The present series of studies is the first to investigate the pharmacological mechanisms underlying d-fenfluramine- and d-norfenfluramine-induced hypophagia in…”
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The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food by THORNTON-JONES, Zoe D, VICKERS, Steven P, CLIFTON, Peter G

“…The CB1 receptor antagonist SR141716A reduces food intake in rats. This effect is likely to depend on modulation of reward related processes. To investigate…”
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The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake by THORNTON-JONES, Zoë D, KENNETT, Guy A, BENWELL, Karen R, REVELL, Dean F, MISRA, Anil, SELLWOOD, Daniel M, VICKERS, Steven P, CLIFTON, Peter G

“…The cannabinoid CB1 receptor inverse agonist rimonabant induces hypophagia and body weight loss. Reduced body weight may potentially be due to decreased food…”
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A comparison of the effects of the CB1 receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour by THORNTON-JONES, Zoë D, KENNETT, Guy A, VICKERS, Steven P, CLIFTON, Peter G

“…Rationale: The cannabinoid CB1 receptor inverse agonist SR141716A (rimonabant) is known to cause hypophagia and this study uses microstructural data to…”
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Serotonin receptor ligands and the treatment of obesity by Vickers, Steven P, Dourish, Colin T

“…It was first established in the 1970s that the brain serotonin (5-HT) system was involved in the control of eating. Subsequent progress in the molecular…”
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Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists by ADAMS, David R, BENTLEY, Jonathan M, MALCOLM, Craig S, MANSELL, Howard L, MISRA, Anil, QUIRK, Kathleen, ROFFEY, Jonathan R. A, VICKERS, Steven P, BENWELL, Karen R, BICKERDIKE, Michael J, BODKIN, Corinna D, CLIFFE, Ian A, DOURISH, Colin T, GEORGE, Ashley R, KENNETT, Guy A, KNIGHT, Antony R

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Little and Often: Ingestive Behavior Patterns Following Hippocampal Lesions in Rats by Clifton, Peter G, Vickers, Steven P, Somerville, Elizabeth M

“…Lesions of both dorsal and ventral hippocampus were produced by multiple infusions of the excitotoxin AMPA. Meal patterns recorded before and after lesioning…”
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5-HT2C Receptor Agonists for the Treatment of Obesity. Biological and Chemical Adventures by David Adams, Sven Taylor, Stephan Röver, Hans Richter, Jean-Marc Plancher, Jacques Mizrahi, Craig S. Malcolm, Antony R. Knight, Guy A. Kennett, Paul Hebeisen, Ian A. Cliffe, Anne Bourson, Caterina Bissantz, Jon M. Bentley, Mike J. Bickerdike, Agnès Bénardeau, Steven P. Vickers

“…Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease and cancer. There is…”
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The utility of animal models to evaluate novel anti-obesity agents: Translational Neuropharmacology - Using Appropriate Animal Models to Guide Clinical Drug Development by VICKERS, Steven P, JACKSON, Helen C, CHEETHAM, Sharon C

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