Antihyperglycemic Activity of Extracts from Boldoa purpurascens Leaves in Alloxan-Induced Diabetic Rats

In order to investigate the potential use of Boldoa purpurascens against diabetes, the antihyperglycemic effect of an ethanol extract obtained from its leaves was evaluated at doses of 50, 100 and 200 mg/kg in rats after induction of hyperglycemia by alloxan. Insulin 5 IU/kg was used as positive con...

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Bibliographic Details
Published in:	Phytotherapy research Vol. 27; no. 5; pp. 721 - 724
Main Authors:	González Mosquera, D. M., Hernandez Ortega, Y., By, B., Vicet Muro, L., Saucedo Hernandez, Y., Grau Ábalos, R., Dehaen, W., Pieters, L., Apers, S.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-05-2013 Wiley Subscription Services, Inc
Subjects:	Animals Blood Glucose - analysis Boldoa purpurascens D-pinitol Diabetes Mellitus, Experimental - drug therapy flavonoids hypoglycemic activity Hypoglycemic Agents - pharmacology Inositol - analogs & derivatives Inositol - chemistry Inositol - pharmacology Male Metformin - therapeutic use Nyctaginaceae Nyctaginaceae - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Rats Rats, Wistar
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Summary:	In order to investigate the potential use of Boldoa purpurascens against diabetes, the antihyperglycemic effect of an ethanol extract obtained from its leaves was evaluated at doses of 50, 100 and 200 mg/kg in rats after induction of hyperglycemia by alloxan. Insulin 5 IU/kg was used as positive control and NaCl 0.9% as negative control. A similar experiment was performed with the aqueous extract used at doses of 50 and 100 mg/kg using metformin at a dose of 50mg/kg as positive control. Statistical analysis was carried using the Kruskal–Wallis test with an interval of trust of 99%. The ethanolic and aqueous extract of B. purpurascens showed a significant decrease of blood glucose levels 72 h after administration. Phytochemical analysis of the ethanol extract showed the presence of D‐pinitol, a compound known for its hypoglycemic properties. In conclusion, ethanolic as well as aqueous extracts of B. purpurascens leaves show antihyperglycemic activity, possibly due to the presence of D‐pinitol and flavonoids. Copyright © 2012 John Wiley & Sons, Ltd.
Bibliography:	ArticleID:PTR4769 ark:/67375/WNG-ZV8W5GM9-M istex:BECAB5338FB98E5C8F4E7D9DF15C607FC2DA9436 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.4769