Search Results - "Vicente‐Blázquez, Alba"

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target by Vicente‐Blázquez, Alba, González, Myriam, Álvarez, Raquel, del Mazo, Sara, Medarde, Manuel, Peláez, Rafael

“…Tubulin, the microtubules and their dynamic behavior are amongst the most successful antitumor, antifungal, antiparasitic, and herbicidal drug targets…”
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Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition by Ramos, Sergio, Vicente-Blázquez, Alba, López-Rubio, Marta, Gallego-Yerga, Laura, Álvarez, Raquel, Peláez, Rafael

“…Antimitotic agents are one of the more successful types of anticancer drugs, but they suffer from toxicity and resistance. The application of approved drugs to…”
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Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine by Alonso-Pérez, Verónica, Hernández, Vanessa, Calzado, Marco A., Vicente-Blázquez, Alba, Gajate, Consuelo, Soler-Torronteras, Rafael, DeCicco-Skinner, Kathleen, Sierra, Angels, Mollinedo, Faustino

“…Metastasis is the leading cause of cancer mortality. Metastatic cancer is notoriously difficult to treat, and it accounts for the majority of cancer-related…”
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Microtubule Destabilizing Sulfonamides as an Alternative to Taxane-Based Chemotherapy by González, Myriam, Ovejero-Sánchez, María, Vicente-Blázquez, Alba, Álvarez, Raquel, Herrero, Ana B, Medarde, Manuel, González-Sarmiento, Rogelio, Peláez, Rafael

“…Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most commonly diagnosed and responsible for most cancer deaths in women. The high…”
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New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure-activity relationships, and molecular modelling by Vicente-Blázquez, Alba, González, Myriam, Medarde, Manuel, Mollinedo, Faustino, Peláez, Rafael

“…Searching for improved indolesulfonamides with higher polarities, 45 new analogues with modifications on the sulfonamide nitrogen, the methoxyaniline, and/or…”
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Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line by González, Myriam, Ovejero-Sánchez, María, Vicente-Blázquez, Alba, Medarde, Manuel, González-Sarmiento, Rogelio, Peláez, Rafael

“…Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and with different substituents on the…”
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Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents by Álvarez, Raquel, Aramburu, Laura, Gajate, Consuelo, Vicente-Blázquez, Alba, Mollinedo, Faustino, Medarde, Manuel, Peláez, Rafael

“…Isocombretastatins are the not isomerizable 1,1-diarylethene isomers of combretastatins. Both families of antimitotics are poorly soluble and new analogs with…”
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Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy by González, Myriam, Ellahioui, Younes, Gallego, Laura, Vicente-Blázquez, Alba, Álvarez, Raquel, Medarde, Manuel, Peláez, Rafael

“…[Display omitted] •A-ring amino derivatives of colchicine site ligands were designed and synthesized.•Amino groups improved solubility.•The most potent…”
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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring by Álvarez, Raquel, Aramburu, Laura, Gajate, Consuelo, Vicente-Blázquez, Alba, Mollinedo, Faustino, Medarde, Manuel, Peláez, Rafael

“…[Display omitted] •Replacement of the 3,4,5-trimethoxyphenyl by 2-methylsulfanyl-6-methoxy-4-pyridyl leads to active analogues.•2,6-Dimethoxypyridine analogues…”
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The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors by González, Myriam, Ellahioui, Younes, Álvarez, Raquel, Gallego-Yerga, Laura, Caballero, Esther, Vicente-Blázquez, Alba, Ramudo, Laura, Marín, Miguel, Sanz, Cristina, Medarde, Manuel, Pelaéz, Rafael

“…Colchicine site ligands suffer from low aqueous solubility due to the highly hydrophobic nature of the binding site. A new strategy for increasing molecular…”
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