Search Results - "Vibhu Prasad"

A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans by Lattmann, Evelyn, Deng, Ting, Walser, Michael, Widmer, Patrizia, Rexha-Lambert, Charlotte, Prasad, Vibhu, Eichhoff, Ossia, Daube, Michael, Dummer, Reinhard, Levesque, Mitchell P, Hajnal, Alex

“…Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. A screen of C. elegans orthologs of genes…”
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SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB by Neufeldt, Christopher J., Cerikan, Berati, Cortese, Mirko, Frankish, Jamie, Lee, Ji-Young, Plociennikowska, Agnieszka, Heigwer, Florian, Prasad, Vibhu, Joecks, Sebastian, Burkart, Sandy S., Zander, David Y., Subramanian, Baskaran, Gimi, Rayomand, Padmanabhan, Seetharamaiyer, Iyer, Radhakrishnan, Gendarme, Mathieu, El Debs, Bachir, Halama, Niels, Merle, Uta, Boutros, Michael, Binder, Marco, Bartenschlager, Ralf

“…SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease;…”
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The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections by Prasad, Vibhu, Suomalainen, Maarit, Jasiqi, Yllza, Hemmi, Silvio, Hearing, Patrick, Hosie, Louise, Burgert, Hans-Gerhard, Greber, Urs F.

“…Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of…”
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SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle by Zimmermann, Liv, Zhao, Xiaohan, Makroczyova, Jana, Wachsmuth-Melm, Moritz, Prasad, Vibhu, Hensel, Zach, Bartenschlager, Ralf, Chlanda, Petr

“…Coronavirus replication is associated with the remodeling of cellular membranes, resulting in the formation of double-membrane vesicles (DMVs). A DMV-spanning…”
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Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation by Twu, Woan-Ing, Lee, Ji-Young, Kim, Heeyoung, Prasad, Vibhu, Cerikan, Berati, Haselmann, Uta, Tabata, Keisuke, Bartenschlager, Ralf

“…Positive-strand RNA viruses replicate in close association with rearranged intracellular membranes. For hepatitis C virus (HCV) and severe acute respiratory…”
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Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation by Tabata, Keisuke, Prasad, Vibhu, Paul, David, Lee, Ji-Young, Pham, Minh-Tu, Twu, Woan-Ing, Neufeldt, Christopher J., Cortese, Mirko, Cerikan, Berati, Stahl, Yannick, Joecks, Sebastian, Tran, Cong Si, Lüchtenborg, Christian, V’kovski, Philip, Hörmann, Katrin, Müller, André C., Zitzmann, Carolin, Haselmann, Uta, Beneke, Jürgen, Kaderali, Lars, Erfle, Holger, Thiel, Volker, Lohmann, Volker, Superti-Furga, Giulio, Brügger, Britta, Bartenschlager, Ralf

“…Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are…”
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Zika virus prM protein contains cholesterol binding motifs required for virus entry and assembly by Goellner, Sarah, Enkavi, Giray, Prasad, Vibhu, Denolly, Solène, Eu, Sungmin, Mizzon, Giulia, Witte, Leander, Kulig, Waldemar, Uckeley, Zina M., Lavacca, Teresa M., Haselmann, Uta, Lozach, Pierre-Yves, Brügger, Britta, Vattulainen, Ilpo, Bartenschlager, Ralf

“…For successful infection of host cells and virion production, enveloped viruses, including Zika virus (ZIKV), extensively rely on cellular lipids. However, how…”
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Analysis of Replication, Cell Division-Mediated Spread, and HBV Envelope Protein-Dependent Pseudotyping of Three Mammalian Delta-like Agents by Gnouamozi, Gnimah Eva, Zhang, Zhenfeng, Prasad, Vibhu, Lauber, Chris, Seitz, Stefan, Urban, Stephan

“…The human hepatitis delta virus (HDV) is a satellite RNA virus that depends on hepatitis B virus (HBV) surface proteins (HBsAg) to assemble into infectious…”
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Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin by Denolly, Solène, Guo, Hongbo, Martens, Miriam, Płaszczyca, Anna, Scaturro, Pietro, Prasad, Vibhu, Kongmanas, Kessiri, Punyadee, Nuntaya, Songjaeng, Adisak, Mairiang, Dumrong, Pichlmair, Andreas, Avirutnan, Panisadee, Bartenschlager, Ralf

“…Dengue virus (DENV) is a major human pathogen that can cause hemorrhagic fever and shock syndrome. One important factor of DENV pathogenicity is non-structural…”
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Plaque2.0-A High-Throughput Analysis Framework to Score Virus-Cell Transmission and Clonal Cell Expansion by Yakimovich, Artur, Andriasyan, Vardan, Witte, Robert, Wang, I-Hsuan, Prasad, Vibhu, Suomalainen, Maarit, Greber, Urs F

“…Classical plaque assay measures the propagation of infectious agents across a monolayer of cells. It is dependent on cell lysis, and limited by user-specific…”
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First person – Vibhu Prasad

“…ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career…”
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A snapshot of protein trafficking in SARS‐CoV‐2 infection by Prasad, Vibhu, Bartenschlager, Ralf

“…SARS‐CoV‐2 is a human pathogenic virus responsible for the COVID‐19 (coronavirus disease 2019) pandemic. The infection cycle of SARS‐CoV‐2 involves several…”
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The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections by Prasad, Vibhu, Greber, Urs F

“…ABSTRACT Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate and adaptive immune responses, which limit…”
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Cell-to-cell and genome-to-genome variability of adenovirus transcription tuned by the cell cycle by Suomalainen, Maarit, Prasad, Vibhu, Kannan, Abhilash, Greber, Urs F

“…In clonal cultures, not all cells are equally susceptible to virus infection and the underlying mechanisms are poorly understood. Here, we developed…”
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A Versatile Reporter System To Monitor Virus-Infected Cells and Its Application to Dengue Virus and SARS-CoV-2 by Pahmeier, Felix, Neufeldt, Christopher J, Cerikan, Berati, Prasad, Vibhu, Pape, Costantin, Laketa, Vibor, Ruggieri, Alessia, Bartenschlager, Ralf, Cortese, Mirko

“…Positive-strand RNA viruses have been the etiological agents in several major disease outbreaks over the last few decades. Examples of this include…”
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Identification of host dependency factors involved in SARS-CoV-2 replication organelle formation through proteomics and ultrastructural analysis by Pahmeier, Felix, Lavacca, Teresa-Maria, Goellner, Sarah, Neufeldt, Christopher J, Prasad, Vibhu, Cerikan, Berati, Rajasekharan, Sreejith, Mizzon, Giulia, Haselmann, Uta, Funaya, Charlotta, Scaturro, Pietro, Cortese, Mirko, Bartenschlager, Ralf

“…Remodeling of the cellular endomembrane system by viruses allows for efficient and coordinated replication of the viral genome in distinct subcellular…”
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Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2 by Prasad, Vibhu, Cerikan, Berati, Stahl, Yannick, Kopp, Katja, Magg, Vera, Acosta-Rivero, Nelson, Kim, Heeyoung, Klein, Katja, Funaya, Charlotta, Haselmann, Uta, Cortese, Mirko, Heigwer, Florian, Bageritz, Josephine, Bitto, David, Jargalsaikhan, Saruul, Neufeldt, Christopher, Pahmeier, Felix, Boutros, Michael, Yamauchi, Yohei, Ruggieri, Alessia, Bartenschlager, Ralf

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remodels the endoplasmic reticulum (ER) to form replication organelles, leading to ER stress and…”
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Chemical induction of unfolded protein response enhances cancer cell killing through lytic virus infection by Prasad, Vibhu, Suomalainen, Maarit, Pennauer, Mirjam, Yakimovich, Artur, Andriasyan, Vardan, Hemmi, Silvio, Greber, Urs F

“…Cancer cells are susceptible to oncolytic viruses, albeit variably. Human adenoviruses (HAdVs) are widely used oncolytic agents that have been engineered to…”
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Assessment of phylogenetic structure in genome size--gene content correlations by Prasad, Vibhu Ranjan, Isler, Karin

“…Gene content and gene-coding percentage can be predicted from genome size in newly sequenced organisms. Here, we investigate whether these predictions are…”
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Cell Cycle-Dependent Kinase Cdk9 Is a Postexposure Drug Target against Human Adenoviruses by Prasad, Vibhu, Suomalainen, Maarit, Hemmi, Silvio, Greber, Urs F

“…Human adenoviruses (HAdVs) infect respiratory, gastrointestinal, and urinary tracts and give rise to eye infections and epidemic keratoconjunctivitis (EKC)…”
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