Search Results - "Viani, Paola"

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure by Lombardi, Marta, Parolisi, Roberta, Scaroni, Federica, Bonfanti, Elisabetta, Gualerzi, Alice, Gabrielli, Martina, Kerlero de Rosbo, Nicole, Uccelli, Antonio, Giussani, Paola, Viani, Paola, Garlanda, Cecilia, Abbracchio, Maria P., Chaabane, Linda, Buffo, Annalisa, Fumagalli, Marta, Verderio, Claudia

“…Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs),…”
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Sphingosine 1-Phosphate Stimulates ER to Golgi Ceramide Traffic to Promote Survival in T98G Glioma Cells by Giussani, Paola, Brioschi, Loredana, Gjoni, Enida, Riccitelli, Elena, Viani, Paola

“…Glioblastoma multiforme is the most common and fatal brain tumor among human cancers. Ceramide (Cer) and Sphingosine 1-phosphate (S1P) have emerged as…”
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Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance by Giussani, Paola, Tringali, Cristina, Riboni, Laura, Viani, Paola, Venerando, Bruno

“…Drug resistance elicited by cancer cells still constitutes a huge problem that frequently impairs the efficacy of both conventional and novel molecular…”
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Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism by Antonucci, Flavia, Turola, Elena, Riganti, Loredana, Caleo, Matteo, Gabrielli, Martina, Perrotta, Cristiana, Novellino, Luisa, Clementi, Emilio, Giussani, Paola, Viani, Paola, Matteoli, Michela, Verderio, Claudia

“…Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way of cell‐to‐cell communication. We have recently shown that microglia,…”
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Secreted miR-153 Controls Proliferation and Invasion of Higher Gleason Score Prostate Cancer by Bertoli, Gloria, Panio, Antonella, Cava, Claudia, Gallivanone, Francesca, Alini, Martina, Strano, Giulia, Molfino, Federico, Brioschi, Loredana, Viani, Paola, Porro, Danilo

“…Prostate cancer (PC) is a male common neoplasm and is the second leading cause of cancer death in American men. PC is traditionally diagnosed by the evaluation…”
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Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells by Abdel Hadi, Loubna, Di Vito, Clara, Marfia, Giovanni, Ferraretto, Anita, Tringali, Cristina, Viani, Paola, Riboni, Laura

“…The plant flavonoid luteolin exhibits different biological effects, including anticancer properties. Little is known on the molecular mechanisms underlying its…”
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Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability by Pezzotta, Alex, Brioschi, Loredana, Carbone, Sabrina, Mazzoleni, Beatrice, Bontempi, Vittorio, Monastra, Federica, Mauri, Laura, Marozzi, Anna, Mione, Marina, Pistocchi, Anna, Viani, Paola

“…Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The invasiveness and the rapid progression that characterize GBM…”
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Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival by Riccitelli, Elena, Giussani, Paola, Di Vito, Clara, Condomitti, Giuseppe, Tringali, Cristina, Caroli, Manuela, Galli, Rossella, Viani, Paola, Riboni, Laura

“…Glioblastomas are the most frequent and aggressive intracranial neoplasms in humans, and despite advances and the introduction of the alkylating agent…”
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Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells by Marfia, Giovanni, Campanella, Rolando, Navone, Stefania Elena, Di Vito, Clara, Riccitelli, Elena, Hadi, Loubna Abdel, Bornati, Andrea, de Rezende, Gisele, Giussani, Paola, Tringali, Cristina, Viani, Paola, Rampini, Paolo, Alessandri, Giulio, Parati, Eugenio, Riboni, Laura

“…Accumulating reports suggest that human glioblastoma contains glioma stem‐like cells (GSCs) which act as key determinants driving tumor growth, angiogenesis,…”
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Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells by Gjoni, Enida, Brioschi, Loredana, Cinque, Alessandra, Coant, Nicolas, Islam, M Nurul, Ng, Carl K-Y, Verderio, Claudia, Magnan, Christophe, Riboni, Laura, Viani, Paola, Le Stunff, Hervé, Giussani, Paola

“…Accumulating evidence suggests that glucolipotoxicity, arising from the combined actions of elevated glucose and free fatty acid levels, acts as a key…”
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HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration by Bassi, Rosaria, Giussani, Paola, Anelli, Viviana, Colleoni, Thomas, Pedrazzi, Marco, Patrone, Mauro, Viani, Paola, Sparatore, Bianca, Melloni, Edon, Riboni, Laura

“…HMGB1 (high mobility group box 1 protein) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation and migration,…”
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Phosphatidylinositol 3-Kinase/AKT Pathway Regulates the Endoplasmic Reticulum to Golgi Traffic of Ceramide in Glioma Cells by Giussani, Paola, Brioschi, Loredana, Bassi, Rosaria, Riboni, Laura, Viani, Paola

“…Different lines of evidence indicate that both aberrant activation of the phosphatidylinositol 3-OH kinase (PI3K)/Akt survival pathway and down-regulation of…”
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The role of sphingolipids in the process of signal transduction by Riboni, Laura, Viani, Paola, Bassi, Rosaria, Prinetti, Alessandro, Tettamanti, Guido

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Age-related differences in synaptosomal peroxidative damage and membrane properties by Viani, P, Cervato, G, Fiorilli, A, Cestaro, B

“…Young, adult, and old rats were used to study the effect of age on the integrity and functioning of brain synaptosomes. An evaluation was made of the…”
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Galactocerebrosidase deficiency induces an increase in lactosylceramide content: A new hallmark of Krabbe disease? by Papini, Nadia, Giallanza, Chiara, Brioschi, Loredana, Ranieri, Francesca Romana, Giussani, Paola, Mauri, Laura, Ciampa, Maria Grazia, Viani, Paola, Tringali, Cristina

“…Galactocerebrosidase (GALC) hydrolyses galactose residues from various substrates, including galactosylceramide, psychosine (galactosylsphingosine), and…”
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Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment by Riganti, Loredana, Antonucci, Flavia, Gabrielli, Martina, Prada, Ilaria, Giussani, Paola, Viani, Paola, Valtorta, Flavia, Menna, Elisabetta, Matteoli, Michela, Verderio, Claudia

“…Growing evidence indicates that sphingosine-1-P (S1P) upregulates glutamate secretion in hippocampal neurons. However, the molecular mechanisms through which…”
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Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors by Pucci, Susanna, Fasoli, Francesca, Moretti, Milena, Benfante, Roberta, Di Lascio, Simona, Viani, Paola, Daga, Antonio, Gordon, Thomas J., McIntosh, Michael, Zoli, Michele, Clementi, Francesco, Gotti, Cecilia

“…[Display omitted] •Choline compounds are highly increased in glioblastoma cells.•Choline is also an agonist of α7- and α9-containing nicotinic receptors.•Both…”
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Persistent cognitive and affective alterations at late withdrawal stages after long-term intermittent exposure to tobacco smoke or electronic cigarette vapour: Behavioural changes and their neurochemical correlates by Ponzoni, Luisa, Braida, Daniela, Carboni, Lucia, Moretti, Milena, Viani, Paola, Clementi, Francesco, Zoli, Michele, Gotti, Cecilia, Sala, Mariaelvina

“…[Display omitted] •Balb/c mice exposed to e-CIG or CIG show marked long-term deficits in cognitive and affective-like behaviour at late withdrawal times.•In…”
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Modifications at C(5) of 2‑(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype by Bavo, Francesco, Pallavicini, Marco, Gotti, Cecilia, Appiani, Rebecca, Moretti, Milena, Colombo, Sara Francesca, Pucci, Susanna, Viani, Paola, Budriesi, Roberta, Renzi, Massimiliano, Fucile, Sergio, Bolchi, Cristiano

“…A series of diastereomeric 2-(2-pyrrolidinyl)-1,4-benzodioxanes bearing a small, hydrogen-bonding substituent at the 7-, 6-, or 5-position of benzodioxane have…”
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Ceramide in Nitric Oxide Inhibition of Glioma Cell Growth by Viani, Paola, Giussani, Paola, Brioschi, Loredana, Bassi, Rosaria, Anelli, Viviana, Tettamanti, Guido, Riboni, Laura

“…The treatment of C6 glioma cells with the nitric oxide donor, PAPANONOate (( Z )-[ N -(3-ammoniopropyl)- N -( n -propyl)amino]diazen-1-ium-1,2-diolate),…”
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