Search Results - "Viali, Satupa‘itea"
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A thrifty variant in CREBRF strongly influences body mass index in Samoans
Published in Nature genetics (01-09-2016)“…Stephen McGarvey and colleagues identify a missense variant in CREBRF strongly associated with body mass index in Samoans. This variant is rare in other…”
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Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand
Published in Diabetologia (01-07-2018)“…Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations…”
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Compound heterozygous splicing variants expand the genotypic spectrum of EMC1‐related disorders
Published in Clinical genetics (01-05-2023)“…EMC1 encodes subunit 1 of the endoplasmic reticulum (ER) membrane protein complex (EMC), a transmembrane domain insertase involved in membrane protein…”
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Advantage in Aging Cognition Associated with the CREBRF variant rs373863828 Among Samoans
Published in GeroPsych (22-05-2024)“…We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan…”
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A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles
Published in HGG advances (12-01-2023)“…Current understanding of lipid genetics has come mainly from studies in European-ancestry populations; limited effort has focused on Polynesian populations,…”
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A Polynesian-specific missense CETP variant alters the lipid profile
Published in HGG advances (13-07-2023)“…Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic…”
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Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa
Published in PloS one (22-12-2023)“…In Samoa, adult Type 2 diabetes prevalence has increased within the past 30 years. Patient preferences for care are factors known to influence treatment…”
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Ongoing transmission of lymphatic filariasis in Samoa 4.5 years after one round of triple-drug mass drug administration
Published in PLoS neglected tropical diseases (01-06-2024)“…Lymphatic filariasis (LF) remains a significant global issue. To eliminate LF as a public health problem, the World Health Organization (WHO) recommends…”
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Anti-filarial antibodies are sensitive indicators of lymphatic filariasis transmission and enable identification of high-risk populations and hotspots
Published in International journal of infectious diseases (01-10-2024)“…•Antibodies (Abs) were a more sensitive indicator of transmission than antigen (Ag).•Higher seroprevalence of Bm14 Ab, Bm33 Ab, and Wb123 Ab compared to Ag was…”
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Field laboratory comparison of STANDARD Q Filariasis Antigen Test (QFAT) with Bioline Filariasis Test Strip (FTS) for the detection of Lymphatic Filariasis in Samoa, 2023
Published in PLoS neglected tropical diseases (01-08-2024)“…To monitor the progress of lymphatic filariasis (LF) elimination programmes, field surveys to assess filarial antigen (Ag) prevalence require access to…”
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Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Published in PloS one (03-06-2024)“…The A allele of rs373863828 in CREB3 regulatory factor is associated with high Body Mass Index, but lower odds of type 2 diabetes. These associations have been…”
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Prevalence of adiposity and associated cardiometabolic risk factors in the samoan genome-wide association study
Published in American journal of human biology (01-07-2014)“…ABSTRACT Objective To describe the prevalence of obesity‐related noncommunicable diseases (NCDs) and associated risk factors in a sample of Samoan adults…”
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13
CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Published in BMJ open diabetes research & care (01-02-2022)“…IntroductionThe minor allele of a missense variant, rs373863828, in CREBRF is associated with higher body mass index (BMI), lower fasting glucose, and lower…”
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Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders
Published in Epigenetics (01-10-2011)“…Lower levels of LINE-1 methylation in peripheral blood have been previously associated with risk of developing non-communicable conditions, the most…”
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Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010-2019
Published in Annals of human biology (01-12-2020)“…The Samoan population has experienced rapid increases in the prevalence of non-communicable diseases (NCDs) and NCD risk factors over the last 30 years…”
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Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale
Published in Frontiers in genetics (13-10-2014)“…Batch effects in DNA methylation microarray experiments can lead to spurious results if not properly handled during the plating of samples. Two pilot studies…”
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Scabies and impetigo in Samoa: A school-based clinical and molecular epidemiological study
Published in The Lancet regional health. Western Pacific (01-01-2021)“…Common infections of the skin such as impetigo and scabies represent a large burden of disease globally, being particularly prevalent in tropical and…”
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The influence of socioeconomic factors on cardiovascular disease risk factors in the context of economic development in the Samoan archipelago
Published in Social science & medicine (1982) (01-11-2006)“…Early in economic development there are positive associations between socioeconomic status (SES) and cardiovascular disease (CVD) risk factors, and in the most…”
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Characterization of sleep apnea among a sample of adults from Samoa
Published in Sleep epidemiology (01-12-2024)“…Sleep apnea is a global public health concern, but little research has examined this issue in low- and middle-income countries, including Samoa. The purpose of…”
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Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands
Published in BMC medical genetics (23-10-2009)“…High blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component…”
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