Search Results - "Veyron, Simon"
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A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins
Published in Nature communications (08-03-2019)“…FIC proteins regulate molecular processes from bacteria to humans by catalyzing post-translational modifications (PTM), the most frequent being the addition of…”
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The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications
Published in eLife (17-01-2020)“…Microtubules are cytoskeletal structures involved in stability, transport and organization in the cell. The building blocks, the α- and β-tubulin heterodimers,…”
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3
Identification and structural characterization of small molecule inhibitors of PINK1
Published in Scientific reports (02-04-2024)“…Mutations in PINK1 and Parkin cause early-onset Parkinson’s Disease (PD). PINK1 is a kinase which functions as a mitochondrial damage sensor and initiates…”
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FIC proteins: from bacteria to humans and back again
Published in Pathogens and disease (01-03-2018)“…During the last decade, FIC proteins have emerged as a large family comprised of a variety of bacterial enzymes and a single member in animals. The air de…”
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Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex
Published in Molecular cell (06-01-2022)“…Mutations in PINK1 cause autosomal-recessive Parkinson’s disease. Mitochondrial damage results in PINK1 import arrest on the translocase of the outer…”
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6
Structure–Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B
Published in Journal of medicinal chemistry (26-09-2024)“…Clostridioides difficile is a bacterium that causes life-threatening intestinal infections. Infection symptoms are mediated by a toxin secreted by the…”
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7
Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering
Published in Biochemical journal (01-04-2017)“…Active, GTP-bound small GTPases need to be attached to membranes by post-translational lipid modifications in order to process and propagate information in…”
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Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding
Published in Structure (London) (03-06-2021)“…The Parkin co-regulated gene protein (PACRG) binds at the inner junction between doublet microtubules of the axoneme, a structure found in flagella and cilia…”
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Genetic, structural and clinical analysis of spastic paraplegia 4
Published in Parkinsonism & related disorders (01-05-2022)“…Spastic paraplegia type 4 (SPG4), resulting from heterozygous mutations in the SPAST gene, is the most common form among the heterogeneous group of hereditary…”
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The Inner Junction Complex of the Cilia is an Interaction Hub that Involves Tubulin Post-translational Modifications
Published in Biophysical journal (07-02-2020)Get full text
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11
GCH1 mutations in hereditary spastic paraplegia
Published in Clinical genetics (01-07-2021)“…GCH1 mutations have been associated with dopa‐responsive dystonia (DRD), Parkinson's disease (PD) and tetrahydrobiopterin (BH4)‐deficient hyperphenylalaninemia…”
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12
A Ca 2+ -regulated deAMPylation switch in human and bacterial FIC proteins
Published in Nature communications (08-03-2019)“…FIC proteins regulate molecular processes from bacteria to humans by catalyzing post-translational modifications (PTM), the most frequent being the addition of…”
Get full text
Journal Article