Search Results - "Vetro, Joseph A"

Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles by Braun, Chad S, Vetro, Joseph A, Tomalia, Donald A, Koe, Gary S, Koe, Janet G, Middaugh, C Russell

“…PAMAM dendrimers are members of a class of polyamine polymers that demonstrate significant gene delivery ability. In this study, a selection of PAMAM…”
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Preliminary evidence that the novel host-derived immunostimulant EP67 can act as a mucosal adjuvant by Karuturi, Bala Vamsi K, Tallapaka, Shailendra B, Phillips, Joy A, Sanderson, Sam D, Vetro, Joseph A

“…Abstract EP67 is a complement component 5a (C5a)-derived peptide agonist of the C5a receptor (CD88) that selectively activates DCs over neutrophils. Systemic…”
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Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization by Parriott, Jacob E, Stewart, Jason P, Smith, D. David, Curran, Stephen M, Bauer, Christopher D, Wyatt, Todd A, Phillips, Joy A, Lyden, Elizabeth, Thiele, Geoffrey M, Vetro, Joseph A

“…Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable…”
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Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC by Ye, Zhen, Abdelmoaty, Mai Mohamed, Curran, Stephen M, Dyavar, Shetty Ravi, Kumar, Devendra, Alnouti, Yazen, Coulter, Don W, Podany, Anthony T, Singh, Rakesh K, Vetro, Joseph A

“…RNA interference (RNAi) molecules have tremendous potential for cancer therapy but are limited by insufficient potency after intravenous (IV) administration…”
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Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo by Vetro, Joseph A., Chang, Yie-Hwa

“…Methionine aminopeptidase type 1 (MetAP1) cotranslationally removes N‐terminal methionine from nascent polypeptides, when the second residue in the primary…”
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Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection by Tallapaka, Shailendra B., Karuturi, Bala V.K., Yeapuri, Pravin, Curran, Stephen M., Sonawane, Yogesh A., Phillips, Joy A., David Smith, D., Sanderson, Sam D., Vetro, Joseph A.

“…[Display omitted] Encapsulation of protein vaccines in biodegradable nanoparticles (NP) increases T-cell expansion after mucosal immunization but requires…”
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Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer by Ye, Zhen, Abdelmoaty, Mai Mohamed, Ambardekar, Vishakha V., Curran, Stephen M., Dyavar, Shetty Ravi, Arnold, Lora L., Cohen, Samuel M., Kumar, Devendra, Alnouti, Yazen, Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.

“…RNA interference molecules have tremendous potential for cancer therapy but are limited by insufficient potency after i.v. administration. We previously found…”
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Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a Diameter-Dependent Manner by Karuturi, Bala V. K, Tallapaka, Shailendra B, Yeapuri, Pravin, Curran, Stephen M, Sanderson, Sam D, Vetro, Joseph A

“…The diameter of biodegradable particles used to coencapsulate immunostimulants and subunit vaccines affects the magnitude of memory CD8+ T cells generated by…”
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Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration by Ambardekar, Vishakha V., Wakaskar, Rajesh R., Ye, Zhen, Curran, Stephen M., McGuire, Timothy R., Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.

“…[Display omitted] RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v…”
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Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors After IV Administration by Wakaskar, Rajesh R., Bathena, Sai Praneeth R., Tallapaka, Shailendra B., Ambardekar, Vishakha V., Gautam, Nagsen, Thakare, Rhishikesh, Simet, Samantha M., Curran, Stephen M., Singh, Rakesh K., Dong, Yuxiang, Vetro, Joseph A.

“…ABSTRACT Purpose Determine the feasibility and potential benefit of peripherally cross-linking the shell of core-shell polymer micelles on the premature…”
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The modification of siRNA with 3′ cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes by Ambardekar, Vishakha V, Han, Huai-Yun, Varney, Michelle L, Vinogradov, Serguei V, Singh, Rakesh K, Vetro, Joseph A

“…Abstract Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many…”
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Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells by Haney, Matthew J, Zhao, Yuling, Li, Shu, Higginbotham, Sheila M, Booth, Stephanie L, Han, Huai-Yun, Vetro, Joseph A, Mosley, R Lee, Kabanov, Alexander V, Gendelman, Howard E, Batrakova, Elena V

“…Our laboratories forged the concept of macrophage delivery of protein antioxidants to attenuate neuroinflammation and nigrostriatal neurodegeneration in…”
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The efficacy of nuclease-resistant Chol-siRNA in primary breast tumors following complexation with PLL-PEG(5K) by Ambardekar, Vishakha V, Wakaskar, Rajesh R, Sharma, Bhawna, Bowman, Joy, Vayaboury, Willy, Singh, Rakesh K, Vetro, Joseph A

“…Abstract Modifying the sense strand of nuclease-resistant siRNA with 3′-cholesterol (Chol-*siRNA) increases mRNA suppression after i.v. administration but with…”
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Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67 by Alshammari, Abdulraman M, Smith, D. David, Parriott, Jake, Stewart, Jason P, Curran, Stephen M, McCulloh, Russell J, Barry, Peter A, Iyer, Smita S, Palermo, Nicholas, Phillips, Joy A, Dong, Yuxiang, Ronning, Donald R, Vennerstrom, Jonathan L, Sanderson, Sam D, Vetro, Joseph A

“…EP67 is a second-generation, human C5a-derived decapeptide agonist of C5a receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over…”
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Effects of the PPARγ agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse by Kakiuchi-Kiyota, Satoko, Vetro, Joseph A., Suzuki, Shugo, Varney, Michelle L., Han, Huai-Yun, Nascimento, Merielen, Pennington, Karen L., Arnold, Lora L., Singh, Rakesh K., Cohen, Samuel M.

“…Peroxisome proliferator-activated receptor gamma (PPARγ) agonists and PPARγ/α dual agonists have been or are being developed for clinical use in the treatment…”
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The Specificity in Vivo of Two Distinct Methionine Aminopeptidases in Saccharomyces cerevisiae by Chen, Shaoping, Vetro, Joseph A., Chang, Yie-Hwa

“…In Saccharomyces cerevisiae, the essential function of amino-terminal methionine removal is provided cotranslationally by two methionine aminopeptidases…”
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Structure/function analysis of peptoid/lipitoid:DNA complexes by Lobo, Brian A, Vetro, Joseph A, Suich, Daniel M, Zuckermann, Ronald N, Middaugh, C Russell

“…Previous transfection studies of cationic peptoid polymers (N-substituted polyglycines) and cationic lipitoid polymers (peptoid-phospholipid conjugates) have…”
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Evidence of a dominant negative mutant of yeast methionine aminopeptidase type 2 in Saccharomyces cerevisiae by Vetro, Joseph A., Dummitt, Benjamin, Micka, William S., Chang, Yie-Hwa

“…Eukaryotic methionine aminopeptidase type 2 (MetAP2, MetAP2 gene (MAP2)), together with eukaryotic MetAP1, cotranslationally hydrolyzes initiator methionine…”
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Musocal vaccine for universal influenza A protection by Phillips, Joy A, Tallapaka, Shailendra B, Vetro, Joseph A, Sanderson, Sam D, Thoman, Marilyn L

“…The rapid mutation rate of the influenza virus requires that the yearly flu vaccine development cycle start months in advance of the flu season. The search for…”
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The modification of siRNA with 3a super(2) cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes by Ambardekar, Vishakha V, Han, Huai-Yun, Varney, Michelle L, Vinogradov, Serguei V, Singh, Rakesh K, Vetro, Joseph A

“…Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many siRNA…”
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