Search Results - "Vetrano, Anna M."

Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity by Szilagyi, John T, Vetrano, Anna M, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract Introduction The breast cancer resistance protein (BCRP/ ABCG2 ) is an efflux transporter in the placental barrier. By transporting chemicals from the…”
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Mechanisms of oxidant generation by catalase by Heck, Diane E., Shakarjian, Michael, Kim, Hong Duck, Laskin, Jeffrey D., Vetrano, Anna M.

“…The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases,…”
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Mono-(2-Ethylhexyl) Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta by Wang, Ximi K, Agarwal, Monica, Parobchak, Nataliya, Rosen, Alex, Vetrano, Anna M, Srinivasan, Aarthi, Wang, Bingbing, Rosen, Todd

“…Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental…”
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Effects of maternal exposure to phthalates and bisphenol A during pregnancy on gestational age by Weinberger, Barry, Vetrano, Anna M., Archer, Faith E., Marcella, Stephen W., Buckley, Brian, Wartenberg, Daniel, Robson, Mark G., Klim, Jammie, Azhar, Sana, Cavin, Sarah, Wang, Lu, Rich, David Q.

“…Abstract Objective: Phthalates and bisphenol A (BPA) are ubiquitous environmental toxicants, present in high concentrations in numerous consumer products. We…”
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Inflammatory Effects of Phthalates in Neonatal Neutrophils by Vetrano, Anna M, Laskin, Debra L, Archer, Faith, Syed, Kirin, Gray, Joshua P, Laskin, Jeffrey D, Nwebube, Nkiru, Weinberger, Barry

“…Hospitalized infants are exposed to numerous devices containing the plasticizer di-(2-ethylhexyl) phthalate. Urinary levels of the phthalate metabolite,…”
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Characterization of the Oxidase Activity in Mammalian Catalase by Vetrano, Anna M., Heck, Diane E., Mariano, Thomas M., Mishin, Vladimir, Laskin, Debra L., Laskin, Jeffrey D.

“…Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to degrade hydrogen peroxide into water and oxygen. In low…”
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Effects of bilirubin on neutrophil responses in newborn infants by Weinberger, Barry, Archer, Faith E, Kathiravan, Suganya, Hirsch, Daniel S, Kleinfeld, Alan M, Vetrano, Anna M, Hegyi, Thomas

“…Newborns are susceptible to inflammatory diseases due to defects in clearing activated immune cells from tissues. Therefore, mechanisms have likely evolved to…”
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Decreased Anti-Inflammatory Responses to Vitamin D in Neonatal Neutrophils by Hirsch, Daniel, Archer, Faith E., Joshi-Kale, Meera, Vetrano, Anna M., Weinberger, Barry

“…Neutrophil activity is prolonged in newborns, suggesting decreased exposure and/or responses to immunosuppressive modulators, such as 1,25-hydroxyvitamin D3…”
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Solar ultraviolet radiation as a trigger of cell signal transduction by Heck, Diane E, Gerecke, Donald R, Vetrano, Anna M, Laskin, Jeffrey D

“…Ultraviolet light radiation in sunlight is known to cause major alterations in growth and differentiation patterns of exposed human tissues. The specific…”
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Mechanisms Mediating Reduced Responsiveness of Neonatal Neutrophils to Lipoxin A4 by Weinberger, Barry, Quizon, Cecile, Vetrano, Anna M, Archer, Faith, Laskin, Jeffrey D, Laskin, Debra L

“…Lipoxin A4 is an eicosanoid that plays a key role in the resolution of neutrophilic inflammation. In these studies, we investigated the hypothesis that…”
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Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters by Gorczyca, Ludwik, Du, Jianyao, Bircsak, Kristin M., Wen, Xia, Vetrano, Anna M., Aleksunes, Lauren M.

“…Low oxygen concentration, or hypoxia, is an important physiological regulator of placental function including chemical disposition. Here, we compared the…”
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Interindividual Regulation of the Breast Cancer Resistance Protein/ ABCG2 Transporter in Term Human Placentas by Bircsak, Kristin M, Moscovitz, Jamie E, Wen, Xia, Archer, Faith, Yuen, Poi Yu Sofia, Mohammed, Moiz, Memon, Naureen, Weinberger, Barry I, Saba, Laura M, Vetrano, Anna M, Aleksunes, Lauren M

“…The breast cancer resistance protein (BCRP/ ) is a maternally-facing efflux transporter that regulates the placental disposition of chemicals. Transcription…”
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Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter by Bircsak, Kristin M, Gupta, Vivek, Yuen, Poi Yu Sofia, Gorczyca, Ludwik, Weinberger, Barry I, Vetrano, Anna M, Aleksunes, Lauren M

“…Glyburide is frequently used to treat gestational diabetes owing to its low fetal accumulation resulting from placental efflux by the breast cancer resistance…”
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UVB light stimulates production of reactive oxygen species: unexpected role for catalase by Heck, Diane E, Vetrano, Anna M, Mariano, Thomas M, Laskin, Jeffrey D

“…In keratinocytes, UVB light stimulates the production of reactive oxygen species (ROS). Lysates of these cells were found to possess a non-dialyzable, trypsin-…”
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Derivatives of 1,2,4-triazole imines acting as dual iNOS and tumor cell growth inhibitors by Guillon, Christophe, Vetrano, Anna M., Saxena, Jaya, Hunter, Angela, Verderone, Geraldine, Finetti, Thomas M., Wisnoski, Jeffrey, DeMatteo, Peter W., Rapp, Robert D., Heindel, Ned D., Joseph, Laurie B., Heck, Diane E., Laskin, Jeffrey D.

“…[Display omitted] •Novel 1,2,4-triazole imines were synthesized and evaluated as iNOS inhibitors.•Some also showed inhibitory growth properties against…”
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Association of prenatal perchlorate, thiocyanate, and nitrate exposure with neonatal size and gestational age by Evans, Kristin A., Rich, David Q., Weinberger, Barry, Vetrano, Anna M., Valentin-Blasini, Liza, Strickland, Pamela Ohman, Blount, Benjamin C.

“…•We related maternal urinary NIS inhibitor levels to fetal growth measurements.•Prenatal exposure to NIS inhibitors was not associated with fetal weight or…”
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Regional expression of the BCRP/ABCG2 transporter in term human placentas by Memon, Naureen, Bircsak, Kristin M., Archer, Faith, Gibson, Christopher J., Ohman-Strickland, Pamela, Weinberger, Barry I., Parast, Mana M., Vetrano, Anna M., Aleksunes, Lauren M.

“…•BCRP mRNA and protein are uniform across the term human placental disc.•GAPDH mRNA was the most appropriate housekeeping gene for expression of BCRP…”
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Effects of Wharton's jelly-derived mesenchymal stem cells on neonatal neutrophils by Khan, Imteyaz, Zhang, Liying, Mohammed, Moiz, Archer, Faith E, Abukharmah, Jehan, Yuan, Zengrong, Rizvi, S Saif, Melek, Michael G, Rabson, Arnold B, Shi, Yufang, Weinberger, Barry, Vetrano, Anna M

“…Mesenchymal stem cells (MSCs) have been proposed as autologous therapy for inflammatory diseases in neonates. MSCs from umbilical cord Wharton's jelly…”
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Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation by Young, Sherri C., Fabio, Karine M., Huang, Mou-Tuan, Saxena, Jaya, Harman, Meredith P., Guillon, Christophe D., Vetrano, Anna M., Heck, Diane E., Flowers II, Robert A., Heindel, Ned D., Laskin, Jeffrey D.

“…ABSTRACT As part of a continuous effort to develop efficient counter measures against sulfur mustard injuries, several unique NSAID prodrugs have been…”
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Influence of labor on neonatal neutrophil apoptosis, and inflammatory activity by WEINBERGER, Barry, VETRANO, Anna M, SYED, Kirin, MURTHY, Sowmya, HANNA, Nazeeh, LASKIN, Jeffrey D, LASKIN, Debra L

“…Neutrophil apoptosis is impaired in neonates, and this contributes to prolonged inflammation and tissue injury in infants after infection or trauma. In the…”
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