Search Results - "Vet, Nienke J"

The impact of lockdown on pediatric ED visits and hospital admissions during the COVID19 pandemic: a multicenter analysis and review of the literature by Kruizinga, Matthijs D., Peeters, Daphne, van Veen, Mirjam, van Houten, Marlies, Wieringa, Jantien, Noordzij, Jeroen G., Bekhof, Jolita, Tramper-Stranders, Gerdien, Vet, Nienke J., Driessen, Gertjan J. A.

“…The coronavirus disease 2019 pandemic has enormous impact on society and healthcare. Countries imposed lockdowns, which were followed by a reduction in care…”
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Optimal sedation in pediatric intensive care patients: a systematic review by Vet, Nienke J., Ista, Erwin, de Wildt, Saskia N., van Dijk, Monique, Tibboel, Dick, de Hoog, Matthijs

“…Purpose Sedatives administered to critically ill children should be titrated to effect, because both under- and oversedation may have negative effects. We…”
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A randomized controlled trial of daily sedation interruption in critically ill children by Vet, Nienke J., de Wildt, Saskia N., Verlaat, Carin W. M., Knibbe, Catherijne A. J., Mooij, Miriam G., van Woensel, Job B. M., van Rosmalen, Joost, Tibboel, Dick, de Hoog, Matthijs

“…Purpose To compare daily sedation interruption plus protocolized sedation (DSI + PS) to protocolized sedation only (PS) in critically ill children. Methods In…”
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The effect of inflammation on drug metabolism: a focus on pediatrics by Vet, Nienke J., de Hoog, Matthijs, Tibboel, Dick, de Wildt, Saskia N.

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Sedation in Critically Ill Children with Respiratory Failure by Vet, Nienke J, Kleiber, Niina, Ista, Erwin, de Hoog, Matthijs, de Wildt, Saskia N

“…This article discusses the rationale of sedation in respiratory failure, sedation goals, how to assess the need for sedation as well as effectiveness of…”
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Randomized controlled trial of daily interruption of sedatives in critically ill children by Verlaat, Carin W. M., Heesen, Ger P., Vet, Nienke J., de Hoog, Matthijs, van der Hoeven, Johannes G., Kox, Matthijs, Pickkers, Peter

“…Summary Aim To study the feasibility of daily interruption of sedatives in critically ill children. Methods Prospective randomized controlled open‐label trial,…”
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Benefit‐Risk Assessment of Off‐Label Drug Use in Children: The Bravo Framework by Zanden, Tjitske M., Mooij, Miriam G., Vet, Nienke J., Neubert, Antje, Rascher, Wolfgang, Lagler, Florian B., Male, Christoph, Grytli, Helene, Halvorsen, Thomas, Hoog, Matthijs, Wildt, Saskia N.

“…A drug is granted a license for use after a thorough assessment of risks and benefits based on high‐quality scientific proof of its efficacy and safety. Many…”
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Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children by Vet, Nienke J, Brussee, Janneke M, de Hoog, Matthijs, Mooij, Miriam G, Verlaat, Carin W M, Jerchel, Isabel S, van Schaik, Ron H N, Koch, Birgit C P, Tibboel, Dick, Knibbe, Catherijne A J, de Wildt, Saskia N

“…Various in vitro, animal, and limited human adult studies suggest a profound inhibitory effect of inflammation and disease on cytochrome P-450 3A…”
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Adverse effect of lockdowns during the COVID-19 pandemic: increased incidence of pediatric crisis admissions due to eating disorders and adolescent intoxications by Kersten, Juliette M., van Veen, Mirjam, van Houten, Marlies A., Wieringa, Jantien, Noordzij, Jeroen G., Bekhof, Jolita, Tramper-Stranders, Gerdien A., Visser-Trip, Héléne, Vet, Nienke J., Kruizinga, Matthijs D.

“…During the COVID-19 pandemic, countries imposed (partial) lockdowns that reduced viral transmission. However, these interventions may have unfavorable effects…”
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Effect of lockdowns on the epidemiology of pediatric respiratory disease—A retrospective analysis of the 2021 summer epidemic by Kruizinga, Matthijs D., Noordzij, Jeroen G., Houten, Marlies A., Wieringa, Jantien, Tramper‐Stranders, Gerdien A., Hira, Vishal, Bekhof, Jolita, Vet, Nienke J., Driessen, Gertjan J. A., Veen, Mirjam

“…Background The imposition of lockdowns during the severe acute respiratory syndrome coronavirus‐2 pandemic led to a significant decrease in pediatric care…”
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Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis by Upadhyay, Parth J., Vet, Nienke J., Goulooze, Sebastiaan C., Krekels, Elke H. J., de Wildt, Saskia N., Knibbe, Catherijne A. J.

“…Aim In critically ill mechanically ventilated children, midazolam is used first line for sedation, however its exact sedative effects have been difficult to…”
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Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure by Brussee, Janneke M., Vet, Nienke J., Krekels, Elke H. J., Valkenburg, Abraham J., Jacqz‐Aigrain, Evelyne, Gerven, Joop M. A., Swart, Eleonora L., Anker, Johannes N., Tibboel, Dick, Hoog, Matthijs, Wildt, Saskia N., Knibbe, Catherijne A. J.

“…Aims Inflammation and organ failure have been reported to have an impact on cytochrome P450 (CYP) 3A‐mediated clearance of midazolam in critically ill…”
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Striving for an effective but parsimonious use of sedation in pediatric intensive care by Vet, Nienke J., de Wildt, Saskia N., Tibboel, Dick, de Hoog, Matthijs

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Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus by Vet, Nienke J., de Winter, Brenda C. M., Koninckx, Muriel, Boeschoten, Shelley A., Boehmer, Annemie L. M., Verhallen, Jacintha T., Plötz, Frans B., Vaessen-Verberne, Anja A., van der Nagel, Bart C. H., Knibbe, Catherijne A. J., Buysse, Corinne M. P., de Wildt, Saskia N., Koch, Birgit C. P., de Hoog, Matthijs

“…Background Intravenous salbutamol is used to treat children with refractory status asthmaticus, however insufficient pharmacokinetic data are available to…”
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Analgesia-sedation in PICU and neurological outcome: a secondary analysis of long-term neuropsychological follow-up in meningococcal septic shock survivors by van Zellem, Lennart, Utens, Elisabeth M, de Wildt, Saskia N, Vet, Nienke J, Tibboel, Dick, Buysse, Corinne

“…To investigate whether analgesic and sedative drug use during PICU treatment is associated with long-term neurodevelopmental outcome in children who survived…”
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Finger-Prick Blood Sampling for Therapeutic Drug Monitoring: Be Aware of Skin Contamination by Nebulized Drugs by de Winter, Brenda C. M., de Hoog, Matthijs, Vet, Nienke J., Dunk-Craaijo, Joke H., Koch, Birgit C. P., de Wildt, Saskia N.

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The effect of critical illness and inflammation on midazolam therapy in children by Vet, Nienke J, de Hoog, Matthijs, Tibboel, Dick, de Wildt, Saskia N

“…To determine the effect of inflammation and disease severity on midazolam pharmacokinetics (as surrogate marker of cytochrome 3A activity) and pharmacodynamics…”
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Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children by Vet, Nienke J., Brussee, Janneke M., de Hoog, Matthijs, Mooij, Miriam G., Verlaat, Carin W. M., Jerchel, Isabel S., van Schaik, Ron H. N., Koch, Birgit C. P., Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.

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Short-Term Health-Related Quality of Life of Critically Ill Children Following Daily Sedation Interruption by Vet, Nienke J, de Wildt, Saskia N, Verlaat, Carin W M, Mooij, Miriam G, Tibboel, Dick, de Hoog, Matthijs, Buysse, Corinne M P

“…Our earlier pediatric daily sedation interruption trial showed that daily sedation interruption in addition to protocolized sedation in critically ill children…”
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Daily interruption of sedation in critically ill children: study protocol for a randomized controlled trial by Vet, Nienke J, de Wildt, Saskia N, Verlaat, Carin W M, Knibbe, Catherijne A J, Mooij, Miriam G, Hop, Wim C J, van Rosmalen, Joost, Tibboel, Dick, de Hoog, Matthijs

“…In adult patients who are critically ill and mechanically ventilated, daily interruption of sedation (DSI) is an effective method of improving sedation…”
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