Search Results - "Vesterinen, H M"

Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted? by Hirst, T C, Vesterinen, H M, Sena, E S, Egan, K J, Macleod, M R, Whittle, I R

“…Background: Malignant glioma is an aggressive tumour commonly associated with a dismal outcome despite optimal surgical and radio-chemotherapy. Since 2005…”
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Meta-analysis of data from animal studies: A practical guide by Vesterinen, H.M., Sena, E.S., Egan, K.J., Hirst, T.C., Churolov, L., Currie, G.L., Antonic, A., Howells, D.W., Macleod, M.R.

“…•Meta-analysis is an invaluable tool in the life sciences.•Methods for the application to clinical data are well documented.•Consideration is required when…”
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Corrigendum to ‘Meta-analysis of data from animal studies: A practical guide’: [Journal of Neuroscience Methods 221 (2014) 92–102] by Vesterinen, H.M., Sena, E.S., Egan, K.J., Hirst, T.C., Churolov, L., Currie, G.L., Antonic, A., Howells, D.W., Macleod, M.R.

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The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease by Egan, K. J., Vesterinen, H. M., McCann, S. K., Sena, E. S., MacLeod, M. R.

“…Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million…”
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A systematic review and meta‐analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy? by Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson McLean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S., Whittle, I. R.

“…Background The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for…”
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From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models by Egan, K.J., Vesterinen, H.M., Beglopoulos, V., Sena, E.S., Macleod, M.R.

“…The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio‐economic challenge. Decades of experimental research have not led to the…”
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Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis by Foley, Peter L., Vesterinen, Hanna M., Laird, Barry J., Sena, Emily S., Colvin, Lesley A., Chandran, Siddharthan, MacLeod, Malcolm R., Fallon, Marie T.

“…The prevalence, associations, and natural history of pain in multiple sclerosis (MS) are poorly understood. The objective of this work was to study the…”
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Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: results from a meta-analysis of large animal studies by Jansen Of Lorkeers, S. J., Eding, J. E. C., Van Der Spoel, T. I. G., Vesterinen, H. M., Koudstaal, S., Sena, E. S., Doevendans, P. A., Macleod, M. R., Chamuleau, S. A. J.

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P60 WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN by Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M., Sena, E. S.

“…INTRODUCTION: The development of new therapeutics is often characterised by promising animal research that fails to translate into clinical efficacy; this…”
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Animal models of bone cancer pain: Systematic review and meta-analyses by Currie, Gillian L., Delaney, Ada, Bennett, Michael I., Dickenson, Anthony H., Egan, Kieren J., Vesterinen, Hanna M., Sena, Emily S., Macleod, Malcolm R., Colvin, Lesley A., Fallon, Marie T.

“…Systematic review identified 38 animal models of bone cancer pain. Reported methodological quality was low; improving this may enhance translation to the…”
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