Search Results - "Vescio, A."

Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial by Lonial, Sagar, Prof, Weiss, Brendan M, Prof, Usmani, Saad Z, Prof, Singhal, Seema, Prof, Chari, Ajai, Prof, Bahlis, Nizar J, Prof, Belch, Andrew, Prof, Krishnan, Amrita, Prof, Vescio, Robert A, Prof, Mateos, Maria Victoria, Prof, Mazumder, Amitabha, Prof, Orlowski, Robert Z, Prof, Sutherland, Heather J, Prof, Bladé, Joan, Prof, Scott, Emma C, Prof, Oriol, Albert, MD, Berdeja, Jesus, MD, Gharibo, Mecide, Prof, Stevens, Don A, MD, LeBlanc, Richard, Prof, Sebag, Michael, Prof, Callander, Natalie, Prof, Jakubowiak, Andrzej, Prof, White, Darrell, Prof, de la Rubia, Javier, Prof, Richardson, Paul G, Prof, Lisby, Steen, MD, Feng, Huaibao, PhD, Uhlar, Clarissa M, PhD, Khan, Imran, MD, Ahmadi, Tahamtan, MD, Voorhees, Peter M, Prof

“…Summary Background New treatment options are needed for patients with multiple myeloma that is refractory to proteasome inhibitors and immunomodulatory drugs…”
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Phase I/II Trial Assessing Bortezomib and Melphalan Combination Therapy for the Treatment of Patients With Relapsed or Refractory Multiple Myeloma by BERENSON, James R, YANG, Hank H, ADAMS, Julian, SCHENKEIN, David, SWIFT, Regina, SADLER, Karen, JARUTIRASARN, Supol G, VESCIO, Robert A, MAPES, Russell, PURNER, Matthew, LEE, Shi-Pyng, WILSON, Joanna, MORRISON, Blake

“…Bortezomib has shown synergy with melphalan in preclinical models. We assessed the safety, tolerability, and response rate in a dose-escalation study of this…”
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The Proteasome Inhibitor PS-341 Markedly Enhances Sensitivity of Multiple Myeloma Tumor Cells to Chemotherapeutic Agents by MA, Mark H, YANG, Hank H, NEESER, Jason, MIKAIL, Amy, ADAMS, Julian, SJAK-SHIE, Nelida, VESCIO, Robert A, BERENSON, James R, PARKER, Kimberly, MANYAK, Steven, FRIEDMAN, Jeffrey M, ALTAMIRANO, Cibby, WU, Zhi-Qun, BORAD, Mitesh J, FRANTZEN, Malka, ROUSSOS, Evanthia

“…Increased nuclear factor κB (NF-κB) activity is associated with increased tumor cell survival in multiple myeloma. The function of NF-κB is inhibited through…”
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Outcomes of the calcaneo-stop procedure for the treatment of juvenile flatfoot in young athletes by Pavone, V., Vescio, A., Di Silvestri, C. A., Andreacchio, A., Sessa, G., Testa, G.

“…Abstract Purpose Flexible flatfoot (FFF) is a widespread condition in juvenile patients. If symptomatic, FFF can require surgical treatment. The calcaneo-stop…”
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Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution by DOUEK, D. C, VESCIO, R. A, BETTS, M. R, BRENCHLEY, J. M, HILL, B. J, LAN ZHANG, BERENSON, J. R, COLLINS, R. H, KOUP, R. A

“…The potential benefits of haematopoietic stem-cell transplantation are tempered by the depletion of T-cells accompanying this procedure. We used a new…”
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Bacterial Community Structure of Acid-Impacted Lakes: What Controls Diversity? by Percent, Sascha F, Frischer, Marc E, Vescio, Paul A, Duffy, Ellen B, Milano, Vincenzo, McLellan, Maggie, Stevens, Brett M, Boylen, Charles W, Nierzwicki-Bauer, Sandra A

“…Although it is recognized that acidification of freshwater systems results in decreased overall species richness of plants and animals, little is known about…”
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Low booster uptake in cancer patients despite health benefits by Figueiredo, Jane C., Levy, Julia, Choi, So Yung, Xu, Alexander M., Merin, Noah M., Hamid, Omid, Lemos, Tucker, Nguyen, Nathalie, Nadri, Maimoona, Gonzalez, Alma, Mahov, Simeon, Darrah, Justin M., Gong, Jun, Paquette, Ronald L., Mita, Alain C., Vescio, Robert A., Salvy, Sarah J., Mehmi, Inderjit, Hendifar, Andrew E., Natale, Ronald, Tourtellotte, Warren G., Ramanujan, V. Krishnan, Huynh, Carissa A., Sobhani, Kimia, Reckamp, Karen L., Merchant, Akil A.

“…Patients with cancer are at increased risk of death from COVID-19 and have reduced immune responses to SARS-CoV2 vaccines, necessitating regular boosters. We…”
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The state of emergency medical technician education in Ghana by Flaherty, Katelyn E, Zakariah, Ahmed N, Vescio, Vicki A, Osei-Ampofo, Maxwell, Mahama, Mohammed-Najeeb, Agongo, Vitus, Becker, Torben K

“…The National Ambulance Service (NAS) provides emergency medical services throughout Ghana and trains emergency medical technicians (EMTs) at the NAS…”
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Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients by Rettig, M. B., Ma, H. J., Vescio, R. A., Põld, M., Schiller, G., Belson, D., Savage, A., Nishikubo, C., Wu, C., Fraser, J., Said, J. W., Berenson, J. R.

“…Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or…”
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Overcoming Drug Resistance in Multiple Myeloma: The Emergence of Therapeutic Approaches to Induce Apoptosis by YANG, Hank H, MA, Mark H, VESCIO, Robert A, BERENSON, James R

“…Drug resistance remains a major clinical challenge for cancer treatment. Early studies suggested that overexpression of P-glycoprotein was a major contributor…”
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Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects by Dubrey, S.W., Reece, D.E., Sanchorawala, V., Hegenbart, U., Merlini, G., Palladini, G., Fermand, J.-P., Vescio, R.A., Bladé, J., Heffner, L.T., Hassoun, H., Liu, X., Enny, C., Ramaswami, P., Elsayed, Y., Van De Velde, H., Mortimer, S., Cakana, A., Comenzo, R.L.

“…Background: Bortezomib is approved for the treatment of multiple myeloma and a role has been suggested in the treatment of systemic AL amyloidosis (AL)…”
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A Phase I Dose-ranging Trial of Monthly Infusions of Zoledronic Acid for the Treatment of Osteolytic Bone Metastases by BERENSON, James R, VESCIO, Robert A, LIPTON, Allan, ROSEN, Lee S, VONTEICHERT, Joseph M, WOO, Margie, SWIFT, Regina, SAVAGE, Allison, GIVANT, Elise, HUPKES, Mieke, HARVEY, Harold

“…Bisphosphonates are potent inhibitors of bone resorption and provide a therapeutic benefit for patients with bone metastases. Zoledronic acid is a highly…”
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Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival by Sanchez, Eric, Li, Mingjie, Kitto, Alex, Li, Jennifer, Wang, Cathy S., Kirk, Dylan T., Yellin, Ori, Nichols, Cydney M., Dreyer, Marissa P., Ahles, Cameryn P., Robinson, Austin, Madden, Erik, Waterman, Gabriel N., Swift, Regina A., Bonavida, Benjamin, Boccia, Ralph, Vescio, Robert A., Crowley, John, Chen, Haiming, Berenson, James R.

“…Summary Although TNFRSF17 (also designated as B‐cell maturation antigen (BCMA)) is expressed on tumour cells in B‐cell malignancies, it has not been found in…”
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Irradiated Bone Marrow Volume is Associated with Hematologic Toxicity in Patients with Multiple Myeloma by Zhang, Samuel C., Kim, Sungjin, Steers, Jennifer, Stiehl, Bradley, Silos, Katrina D., Grigsby, Giana, Oorloff, Maria, Upadhaya, Taman, Vescio, Robert A., Oveisi, David R., Hakimian, Behrooz, Atkins, Katelyn M., Ballas, Leslie K.

“…Purpose/Objective(s): Palliative radiotherapy (RT) is effective for multiple myeloma (MM) but may cause cytopenia. Bone marrow volume receiving 10Gy (BMV10Gy)…”
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A Phase I Study to Assess the Safety and Pharmacokinetics of Single-agent Lorvotuzumab Mertansine (IMGN901) in Patients with Relapsed and/or Refractory CD–56-positive Multiple Myeloma by Ailawadhi, Sikander, Kelly, Kevin R., Vescio, Robert A., Jagannath, Sundar, Wolf, Jeffrey, Gharibo, Mecide, Sher, Taimur, Bojanini, Leyla, Kirby, Maurice, Chanan-Khan, Asher

“…Lorvotuzumab mertansine, a unique antibody–drug conjugate targeting CD56, is frequently expressed on multiple myeloma cells. The present phase I trial of the…”
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Efficacy and safety of once-weekly and twice-weekly bortezomib in patients with relapsed systemic AL amyloidosis: results of a phase 1/2 study by Reece, Donna E., Hegenbart, Ute, Sanchorawala, Vaishali, Merlini, Giampaolo, Palladini, Giovanni, Bladé, Joan, Fermand, Jean-Paul, Hassoun, Hani, Heffner, Leonard, Vescio, Robert A., Liu, Kevin, Enny, Christopher, Esseltine, Dixie-Lee, van de Velde, Helgi, Cakana, Andrew, Comenzo, Raymond L.

“…This first prospective phase 2 study of single-agent bortezomib in relapsed primary systemic AL amyloidosis evaluated the recommended (maximum planned) doses…”
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Identification of a New, Unorthodox Member of the MAGE Gene Family by Põld, Mehis, Zhou, Jin, Chen, Grace L., Hall, Jeffrey M., Vescio, Robert A., Berenson, James R.

“…Several tumor-associated antigen families, such as MAGE, GAGE/PAGE, PRAME, BAGE, and LAGE/NY-ESO-1, exist. These antigens are of particular interest in tumor…”
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Development of the Histoculture Drug Response Assay (HDRA) by Hoffman, Robert M, Vescio, Robert A

“…The histoculture drug response assay (HDRA) was developed using Gelfoam histoculture of all tumor types. Twenty tumor classes, including all the major ones,…”
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Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma by SAID, J. W, RETTIG, M. R, ASOU, H, PINKUS, G, PINKUS, J, SCHRAGE, M, GREEN, E, BERENSON, J. R, HEPPNER, K, VESCIO, R. A, SCHILLER, G, MA, H. J, BELSON, D, SAVAGE, A, SHINTAKU, I. P, KOEFFLER, H. P

“…We have recently demonstrated the presence of Kaposi's sarcoma-associated herpesvirus (KSHV) in cultured bone marrow (BM) stromal dendritic cells from all…”
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Long-term follow-up from a phase 1/2 study of single-agent bortezomib in relapsed systemic AL amyloidosis by Reece, Donna E., Hegenbart, Ute, Sanchorawala, Vaishali, Merlini, Giampaolo, Palladini, Giovanni, Bladé, Joan, Fermand, Jean-Paul, Hassoun, Hani, Heffner, Leonard, Kukreti, Vishal, Vescio, Robert A., Pei, Lixia, Enny, Christopher, Esseltine, Dixie-Lee, van de Velde, Helgi, Cakana, Andrew, Comenzo, Raymond L.

“…CAN2007 was a phase 1/2 study of once- and twice-weekly single-agent bortezomib in relapsed primary systemic amyloid light chain amyloidosis (AL) amyloidosis…”
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