Search Results - "Vervoort, Stephin J."

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML by Duarte, Delfim, Hawkins, Edwin D., Akinduro, Olufolake, Ang, Heather, De Filippo, Katia, Kong, Isabella Y., Haltalli, Myriam, Ruivo, Nicola, Straszkowski, Lenny, Vervoort, Stephin J., McLean, Catriona, Weber, Tom S., Khorshed, Reema, Pirillo, Chiara, Wei, Andrew, Ramasamy, Saravana K., Kusumbe, Anjali P., Duffy, Ken, Adams, Ralf H., Purton, Louise E., Carlin, Leo M., Lo Celso, Cristina

“…Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid…”
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Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion by Freeman, Andrew J., Vervoort, Stephin J., Ramsbottom, Kelly M., Kelly, Madison J., Michie, Jessica, Pijpers, Lizzy, Johnstone, Ricky W., Kearney, Conor J., Oliaro, Jane

“…Despite the clinical success of cancer immunotherapies, the majority of patients fail to respond or develop resistance through disruption of pathways that…”
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BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1 by Hogg, Simon J., Vervoort, Stephin J., Deswal, Sumit, Ott, Christopher J., Li, Jason, Cluse, Leonie A., Beavis, Paul A., Darcy, Phillip K., Martin, Benjamin P., Spencer, Andrew, Traunbauer, Anna K., Sadovnik, Irina, Bauer, Karin, Valent, Peter, Bradner, James E., Zuber, Johannes, Shortt, Jake, Johnstone, Ricky W.

“…BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that maximal therapeutic effects…”
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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis by Kelly, Madison J., So, Joan, Rogers, Amy J., Gregory, Gareth, Li, Jason, Zethoven, Magnus, Gearhart, Micah D., Bardwell, Vivian J., Johnstone, Ricky W., Vervoort, Stephin J., Kats, Lev M.

“…The BCL6 Corepressor (BCOR) is a component of a variant Polycomb repressive complex 1 (PRC1) that is essential for normal development. Recurrent mutations in…”
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SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition by Vervoort, Stephin J, Lourenço, Ana Rita, van Boxtel, Ruben, Coffer, Paul J

“…The epithelial to mensenchymal transition program regulates various aspects of embryonic development and tissue homeostasis, but aberrant activation of this…”
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Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression by Peeters, Janneke G.C., Vervoort, Stephin J., Tan, Sander C., Mijnheer, Gerdien, de Roock, Sytze, Vastert, Sebastiaan J., Nieuwenhuis, Edward E.S., van Wijk, Femke, Prakken, Berent J., Creyghton, Menno P., Coffer, Paul J., Mokry, Michal, van Loosdregt, Jorg

“…The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited…”
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C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition by Lourenço, Ana Rita, Roukens, M. Guy, Seinstra, Danielle, Frederiks, Cynthia L., Pals, Cornelieke E., Vervoort, Stephin J., Margarido, Andreia S., van Rheenen, Jacco, Coffer, Paul J.

“…Extracellular signals such as TGF-β can induce epithelial-to-mesenchymal transition (EMT) in cancers of epithelial origin, promoting molecular and phenotypical…”
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Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy by van der Vos, Kristan E., Eliasson, Pernilla, Proikas-Cezanne, Tassula, Vervoort, Stephin J., van Boxtel, Ruben, Putker, Marrit, van Zutphen, Iris J., Mauthe, Mario, Zellmer, Sebastian, Pals, Cornelieke, Verhagen, Liesbeth P., Groot Koerkamp, Marian J. A., Braat, A. Koen, Dansen, Tobias B., Holstege, Frank C., Gebhardt, Rolf, Burgering, Boudewijn M., Coffer, Paul J.

“…The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation of cell proliferation, survival and stress resistance. Here we…”
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Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma by Costacurta, Matteo, Vervoort, Stephin J., Hogg, Simon J., Martin, Benjamin P., Johnstone, Ricky W., Shortt, Jake

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BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members by Hogg, Simon J, Newbold, Andrea, Vervoort, Stephin J, Cluse, Leonie A, Martin, Benjamin P, Gregory, Gareth P, Lefebure, Marcus, Vidacs, Eva, Tothill, Richard W, Bradner, James E, Shortt, Jake, Johnstone, Ricky W

“…Targeting BET bromodomain proteins using small molecules is an emerging anticancer strategy with clinical evaluation of at least six inhibitors now underway…”
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SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression by Braccioli, Luca, Vervoort, Stephin J., Puma, Gianmarco, Nijboer, Cora H., Coffer, Paul J.

“…SOX4 has been shown to promote neuronal differentiation both in the adult and embryonic neural progenitors. Ectopic SOX4 expression has also been shown to…”
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Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia by So, Joan, Lewis, Alexander C, Smith, Lorey K, Stanley, Kym, Franich, Rheana, Yoannidis, David, Pijpers, Lizzy, Dominguez, Pilar, Hogg, Simon J, Vervoort, Stephin J, Brown, Fiona C, Johnstone, Ricky W, McDonald, Gabrielle, Ulanet, Danielle B, Murtie, Josh, Gruber, Emily, Kats, Lev M

“…The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes one of the rate‐limiting steps in de novo pyrimidine biosynthesis, a pathway that…”
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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity by Djajawi, Tirta M., Pijpers, Lizzy, Srivaths, Akash, Chisanga, David, Chan, Kok Fei, Hogg, Simon J., Neil, Liam, Rivera, Sarahi Mendoza, Bartonicek, Nenad, Ellis, Sarah L., Lim Kam Sian, Terry C.C., Faridi, Pouya, Liao, Yang, Pal, Bhupinder, Behren, Andreas, Shi, Wei, Vervoort, Stephin J., Johnstone, Ricky W., Kearney, Conor J.

“…Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct…”
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Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome by Tufegdzic Vidakovic, Ana, Rueda, Oscar M., Vervoort, Stephin J., Sati Batra, Ankita, Goldgraben, Mae Akilina, Uribe-Lewis, Santiago, Greenwood, Wendy, Coffer, Paul J., Bruna, Alejandra, Caldas, Carlos

“…The transforming growth factor beta (TGF-β) signaling pathway exerts opposing effects on cancer cells, acting as either a tumor promoter or a tumor suppressor…”
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FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression by Braccioli, Luca, Vervoort, Stephin J., Adolfs, Youri, Heijnen, Cobi J., Basak, Onur, Pasterkamp, R. Jeroen, Nijboer, Cora H., Coffer, Paul J.

“…Mutations in FOXP1 have been linked to neurodevelopmental disorders including intellectual disability and autism; however, the underlying molecular mechanisms…”
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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity by House, Imran G., Derrick, Emily B., Sek, Kevin, Chen, Amanda X.Y., Li, Jasmine, Lai, Junyun, Todd, Kirsten L., Munoz, Isabelle, Michie, Jessica, Chan, Cheok Weng, Huang, Yu-Kuan, Chan, Jack D., Petley, Emma V., Tong, Junming, Nguyen, DatMinh, Engel, Sven, Savas, Peter, Hogg, Simon J., Vervoort, Stephin J., Kearney, Conor J., Burr, Marian L., Lam, Enid Y.N., Gilan, Omer, Bedoui, Sammy, Johnstone, Ricky W., Dawson, Mark A., Loi, Sherene, Darcy, Phillip K., Beavis, Paul A.

“…CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought to develop therapeutic strategies to enhance…”
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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity by House, Imran G., Derrick, Emily B., Sek, Kevin, Chen, Amanda X.Y., Li, Jasmine, Lai, Junyun, Todd, Kirsten L., Munoz, Isabelle, Michie, Jessica, Chan, Cheok Weng, Huang, Yu-Kuan, Chan, Jack D., Petley, Emma V., Tong, Junming, Nguyen, DatMinh, Engel, Sven, Savas, Peter, Hogg, Simon J., Vervoort, Stephin J., Kearney, Conor J., Burr, Marian L., Lam, Enid Y.N., Gilan, Omer, Bedoui, Sammy, Johnstone, Ricky W., Dawson, Mark A., Loi, Sherene, Darcy, Phillip K., Beavis, Paul A.

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Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis by Vervoort, Stephin J, de Jong, Olivier G, Roukens, M Guy, Frederiks, Cynthia L, Vermeulen, Jeroen F, Lourenço, Ana Rita, Bella, Laura, Vidakovic, Ana Tufegdzic, Sandoval, José L, Moelans, Cathy, van Amersfoort, Miranda, Dallman, Margaret J, Bruna, Alejandra, Caldas, Carlos, Nieuwenhuis, Edward, van der Wall, Elsken, Derksen, Patrick, van Diest, Paul, Verhaar, Marianne C, Lam, Eric W-F, Mokry, Michal, Coffer, Paul J

“…The expression of the transcription factor is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the…”
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In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction by Steins, Anne, Dik, Pieter, Müller, Wally H, Vervoort, Stephin J, Reimers, Kerstin, Kuhbier, Jörn W, Vogt, Peter M, van Apeldoorn, Aart A, Coffer, Paul J, Schepers, Koen

“…Reconstruction of the bladder by means of both natural and synthetic materials remains a challenge due to severe adverse effects such as mechanical failure…”
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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation by Kong, Isabella Y., Rimes, Joel S., Light, Amanda, Todorovski, Izabela, Jones, Sarah, Morand, Eric, Knight, Deborah A., Bergman, Ylva E., Hogg, Simon J., Falk, Hendrik, Monahan, Brendon J., Stupple, Paul A., Street, Ian P., Heinzel, Susanne, Bouillet, Philippe, Johnstone, Ricky W., Hodgkin, Philip D., Vervoort, Stephin J., Hawkins, Edwin D.

“…JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody…”
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