Search Results - "Vervest, Ivan"

Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain by Wagschal, Simon, Broggini, Diego, Cao, Trung D.C., Schleiss, Pascal, Paun, Kristian, Steiner, Jessica, Merk, Anna-Lena, Harsdorf, Joachim, Fiedler, Winfried, Schirling, Stefan, Hock, Sven, Strittmatter, Tobias, Dijkmans, Jan, Vervest, Ivan, Van Hoegaerden, Tim, Egle, Brecht, Mower, Matthew P., Liu, Zhi, Cao, Zhiyong, He, Xiaoning, Chen, Lei, Qin, Lei, Tan, Hongyu, Yan, Jun, Cunière, Nicolas Lucien, Wei, Carolyn S., Vuyyuru, Venkata, Ayothiraman, Rajaram, Rangaswamy, Sundaramurthy, Jaleel, Mohamed, Vaidyanathan, Rajappa, Eastgate, Martin D., Klep, Richard, Benhaïm, Cyril, Vogels, Ilse, Peeters, Koen, Lemaire, Sébastien

“…Anticoagulants play a critical role in the prevention and treatment of thrombotic-driven cardiovascular diseases. Factor XIa (FXIa) inhibitors have the…”
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Safety Concerns Regarding the Transportation of Organic Powders on Dry Ice: How CO2 Adsorption Can Lead to Powder Spills by Dermaut, Wim, van Dun, Jan, De Kock, Jan, Vervest, Ivan, Fannes, Christine

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Safety Concerns Regarding the Transportation of Organic Powders on Dry Ice: How CO 2 Adsorption Can Lead to Powder Spills by Dermaut, Wim, van Dun, Jan, De Kock, Jan, Vervest, Ivan, Fannes, Christine

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Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) and RWJ444772 (R290629) by Willemsens, Bert, Vervest, Ivan, Ormerod, Dominic, Aelterman, Wim, Fannes, Christine, Mertens, Narda, Markó, István E, Lemaire, Sebastien

“…A scalable and safe process for the oxidative rearrangement of β-carboline to quinolone derivatives, intermediates in the synthesis of PDE-V inhibitors…”
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Conversion of the Laboratory Synthetic Route of the N-Aryl-2-benzothiazolamine R116010 to a Manufacturing Method by Aelterman, Wim, Lang, Yolande, Willemsens, Bert, Vervest, Ivan, Leurs, Stef, De Knaep, Fons

“…A facile and large-scale preparation of the antitumor agent R116010 has been developed. The new synthetic process requires four steps: (i) Friedel−Crafts…”
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Development of a Scalable and Safe Procedure for the Production of (3 R )-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9 H -pyrrolo[3,4- b ]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) and RWJ444772 (R290629) by Willemsens, Bert, Vervest, Ivan, Ormerod, Dominic, Aelterman, Wim, Fannes, Christine, Mertens, Narda, Markó, István E., Lemaire, Sebastien

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Synthesis of T2288:  From Bench Synthesis to Pilot Production by Guillaume, Michel, Cuypers, Jef, Vervest, Ivan, De Smaele, Dirk, Leurs, Stef

“…A practical process to make N-(2,6-dimethylphenyl)-2-piperazin-1-yl-acetamide 1 is described, starting from piperazine 2 and N-chloroacetyl-2,6-xylidine 3. The…”
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