Search Results - "Vertongen, P"

Identification of key residues for the binding of glucagon to the N-terminal domain of its receptor: an alanine scan and modeling study by Prévost, M, Vertongen, P, Waelbroeck, M

“…Glucagon plays an essential role in the glycemia maintenance during fasting, but also aggravates hyperglycemia in diabetic patients. A series of analogues of…”
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Two Basic Residues of the h-VPAC1 Receptor Second Transmembrane Helix Are Essential for Ligand Binding and Signal Transduction by Solano, Rosa Maria, Langer, Ingrid, Perret, Jason, Vertongen, Pascale, Juarranz, Maria Guillerma, Robberecht, Patrick, Waelbroeck, Magali

“…We mutated the vasoactive intestinal peptide (VIP) Asp3 residue and two VPAC1receptor second transmembrane helix basic residues (Arg188and Lys195). VIP had a…”
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Conversion of atrial fibrillation to sinus rhythm and rate control by digoxin in comparison to placebo by Jordaens, L., Trouerbach, J., Calle, P., Tavernier, R., Derycke, E., Vertongen, P., Bergez, B., Vandekerckhove, Y.

“…Aims A randomized, double-blind study with a high dose of digoxin administered intravenously for conversion of atrial fibrillation (not due to haemodynamic…”
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The long-acting vasoactive intestinal polypeptide agonist RO 25-1553 is highly selective of the VIP2 receptor subclass by Gourlet, P, Vertongen, P, Vandermeers, A, Vandermeers-Piret, M C, Rathe, J, De Neef, P, Waelbroeck, M, Robberecht, P

“…RO 25-1553 is a synthetic VIP analogue that induced a long-lasting relaxation of tracheal and bronchial smooth muscles as well as a reduction of edema and…”
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Relative quantitative analysis of glucagon receptor mRNA in rat tissues by Svoboda, M, Tastenoy, M, Vertongen, P, Robberecht, P

“…Total RNA prepared from nine rat tissues were analyzed for their content in glucagon receptor mRNA by two independent hybridization approaches: (1) simple dot…”
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Lysine 195 and aspartate 196 in the first extracellular loop of the VPAC1 receptor are essential for high affinity binding of agonists but not of antagonists by LANGER, I, VERTONGEN, P, PERRET, J, WAELBROECK, M, ROBBERECHT, P

“…The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the…”
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Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours by Van Laethem, J L, Vertongen, P, Deviere, J, Van Rampelbergh, J, Rickaert, F, Cremer, M, Robberecht, P

“…Differential diagnosis of pancreatic cancer and chronic pancreatitis is sometimes difficult and cytological examination of brushings or aspirated material…”
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Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC2: role of basic residues in the second transmembrane helix by Vertongen, P, Solano, R M, Perret, J, Langer, I, Robberecht, P, Waelbroeck, M

“…We investigated the role of two conserved basic residues in the second transmembrane helix arginine 172 (R172) and lysine 179 (K179) of the VPAC2 receptor…”
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Identification of secretin, vasoactive intestinal peptide and glucagon binding sites: from chimaeric receptors to point mutations by Waelbroeck, M, Perret, J, Vertongen, P, Van Craenenbroeck, M, Robberecht, P

“…We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors…”
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Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation by Perret, J, Vertongen, P, Solano, R M, Langer, I, Cnudde, J, Robberecht, P, Waelbroeck, M

“…We investigated the human vasoactive intestinal polypeptide (VIP) receptors VPAC1 and VPAC2 mutated at conserved tyrosine residues in the first transmembrane…”
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Proline residue 280 in the second extracellular loop (EC2) of the VPAC2 receptor is essential for the receptor structure by Vertongen, P, Solano, R M, Juarranz, M G, Perret, J, Waelbroeck, M, Robberecht, P

“…Inspection of the amino acid sequence of the human VPAC1 and the VPAC2 receptors after alignment of the conserved residues indicates that the second…”
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VIP and pituitary adenylate cyclase activating polypeptide (PACAP) have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptor by VERTONGEN, P, CAMBY, I, DARRO, F, KISS, R, ROBBERECHT, P

“…Functional VIP/PACAP receptors were identified in the human glioblastoma cell line T98G, based on the relative potency of VIP, PACAP and PACAP-38 to stimulate…”
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Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas by Robberecht, P, Vertongen, P, Velkeniers, B, de Neef, P, Vergani, P, Raftopoulos, C, Brotchi, J, Hooghe-Peters, E L, Christophe, J

“…The presence of pituitary adenylate cyclase activating polypeptide (PACAP) receptors coupled to adenylate cyclase was investigated in four types of human…”
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Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors by Robberecht, P, Woussen-Colle, M C, Vertongen, P, De Neef, P, Hou, X, Salmon, I, Brotchi, J

“…Twenty-three human gliomas were analyzed: 13 astroglial neoplasms including three grade II, four grade III, and six grade IV tumors; seven ependymomas; and…”
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Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes are differently expressed in rat transplanted pituitary tumours (SMtTW) and in the normal gland by Vertongen, P, Delhase, M, Rajas, F, Trouillas, J, Hooghe-Peters, E, Svoboda, M, Robberecht, P

“…The expression of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide (PACAP/VIP) receptor subtypes was evaluated in the…”
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Experience of cardioverter-defibrillators inserted without thoracotomy: evaluation of transvenously inserted intracardiac leads alone or with a subcutaneous axillary patch by Jordaens, L, Trouerbach, J W, Vertongen, P, Herregods, L, Poelaert, J, Van Nooten, G

“…OBJECTIVES--To compare the efficacy of a purely transvenous cardioverter-defibrillator (ICD) system with that of a system with a supplementary subcutaneous…”
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Comparison between vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide levels in neuroblastoma tumour tissues by Vertongen, P, De Clerck, P, Fournet, J.-C, Martelli, H, Hélardot, P, Devalck, C, Peeters, T, Sariban, E, Robberecht, P

“…Vasoactive intestinal polypeptide (VIP) is reported to exert an autocrine control on neuroblastoma cell tumours: VIP is produced by the tumour and stimulates…”
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Status of the ITER vacuum vessel construction by Choi, C.H., Sborchia, C., Ioki, K., Giraud, B., Utin, Yu, Sa, J.W., Wang, X., Teissier, P., Martinez, J.M., Le Barbier, R., Jun, C., Dani, S., Barabash, V., Vertongen, P., Alekseev, A., Jucker, P., Bayon, A., Pathak, H., Raval, J., Ahn, H.J., Kim, B.C., Kuzmin, E., Savrukhin, P.

“…•Final design of the ITER vacuum vessel (VV).•Procurement of the ITER VV.•Manufacturing results of real scale mock-ups.•Manufacturing status of the VV in…”
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Characterization of the VIP receptor from SUP T1 lymphoblasts by Robberecht, Patrick, Gourlet, Philippe, Vertongen, Pascale, Svoboda, Michal

“…The SUP T1 lymphoblasts express an original subtype of VIP receptors characterized by a high affinity for the VIP analogue from lizard venom named helodermin,…”
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Assurance of Sound Manufacturing Technology for the ITER Current Leads by Bauer, Pierre, Kaizong Ding, Chen-yu Gung, Ichihara, T., Niu, E., Guang Shen, Taylor, T., Vertongen, P., Tingzhi Zhou

“…The ITER current leads will transfer large currents of up to 68 kA into the superconducting magnets of the tokamak. Following the development of the designs of…”
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