Search Results - "Vertino, P"

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion by Konen, J., Summerbell, E., Dwivedi, B., Galior, K., Hou, Y., Rusnak, L., Chen, A., Saltz, J., Zhou, W., Boise, L. H., Vertino, P., Cooper, L., Salaita, K., Kowalski, J., Marcus, A. I.

“…Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this heterogeneity, we developed an image-guided genomics technique…”
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Predicting Aberrant CpG Island Methylation by Feltus, F. A., Lee, E. K., Costello, J. F., Plass, C., Vertino, P. M.

“…Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human…”
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Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer by Kennedy, E. M., Powell, D. R., Li, Z., Bell, J. S. K., Barwick, B. G., Feng, H., McCrary, M. R., Dwivedi, B., Kowalski, J., Dynan, W. S., Conneely, K. N., Vertino, P. M.

“…Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and…”
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Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways by Sharma, D, Saxena, N K, Vertino, P M, Anania, F A

“…An increase in the risk of cancer is one of the consequences of obesity. The predominant cancers associated with obesity have a hormonal basis and include…”
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Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia by Gaudette, B T, Dwivedi, B, Chitta, K S, Poulain, S, Powell, D, Vertino, P, Leleu, X, Lonial, S, Chanan-Khan, A A, Kowalski, J, Boise, L H

“…Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The…”
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Dual role of TMS1 ASC in death receptor signaling by PARSONS, M. J, VERTINO, P. M

“…Aberrant DNA methylation of promoter region CpG islands is associated with gene silencing and serves as an alternative to mutations in the inactivation of…”
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TMS1/ASC: the cancer connection by McConnell, B B, Vertino, P M

“…TMS1/ASC is a bipartite protein comprising two protein-protein interaction domains, a pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins…”
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Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1 by MCCONNELL, Beth B, VERTINO, Paula M

“…Genetic and epigenetic alterations affecting proteins involved in apoptosis can contribute to the establishment and progression of cancer. Recently, our…”
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De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase by Vertino, Paula M., Yen, Ray-Whay Chiu, Gao, Jin, Baylin, Stephen B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Switch from Monoallelic to Biallelic Human IGF2 Promoter Methylation during Aging and Carcinogenesis by Issa, Jean-Pierre J., Vertino, Paula M., Boehm, Corinne D., Newsham, Irene F., Baylin, Stephen B.

“…We have previously linked aging, carcinogenesis, and de novo methylation within the promoter of the estrogen receptor (ER) gene in human colon. We now examine…”
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Alterations in DNA methylation: a fundamental aspect of neoplasia by Baylin, S B, Herman, J G, Graff, J R, Vertino, P M, Issa, J P

“…Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more regional areas of hypermethylation, and increased DNA-methyltransferase…”
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Increased cytosine DNA-methyltransferase activity during colon cancer progression by Issa, J P, Vertino, P M, Wu, J, Sazawal, S, Celano, P, Nelkin, B D, Hamilton, S R, Baylin, S B

“…Molecular changes during progressive stages of colon cancer and other human tumors commonly involve altered regulation of DNA methylation. These changes…”
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TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers by CONWAY, Kerry E, MCCONNELL, Beth B, BOWRING, Claire E, DONALD, Carlton D, WARREN, Stephen T, VERTINO, Paula M

“…Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to…”
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Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation by Graff, J R, Herman, J G, Myöhänen, S, Baylin, S B, Vertino, P M

“…Promoter region CpG island methylation is associated with tumor suppressor gene silencing in neoplasia. GenBank sequence analyses revealed that a number of CpG…”
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Isolation and characterization of the cDNA encoding human DNA methyltransferase by Yen, Ray-Whay Chiu, Vertino, Paula M., Nelkin, Barry D., Yu, Jane J., El-Deiry, Wafik, Cumaraswamy, Arunthathi, Lennon, Gregory G., Trask, Barbara J., Celano, Paul, Baylin, Stephen B.

“…We have cloned a series of overlapping cDNA clones encoding a 5194 bp transcript for human DNA methyltransferase (DNA MTase). This sequence potentially codes…”
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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences by Lin, Yanni, Cradick, Thomas J, Brown, Matthew T, Deshmukh, Harshavardhan, Ranjan, Piyush, Sarode, Neha, Wile, Brian M, Vertino, Paula M, Stewart, Frank J, Bao, Gang

“…CRISPR/Cas9 systems are a versatile tool for genome editing due to the highly efficient targeting of DNA sequences complementary to their RNA guide strands…”
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Effects of methylation on expression of TMS1 ASC in human breast cancer cells by LEVINE, Jeoffrey J, STIMSON-CRIDER, Krista M, VERTINO, Paula M

“…Gene silencing associated with aberrant methylation of promoter region CpG islands is one mechanism in which tumor suppressor genes are inactivated in human…”
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Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells by Ferguson, Anne T., Vertino, Paula M., Spitzner, Jeffrey R., Baylin, Stephen B., Muller, Mark T., Davidson, Nancy E.

“…The cytosine analog 5-aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms…”
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Methylation-mediated Silencing of TMS1/ASC Is Accompanied by Histone Hypoacetylation and CpG Island-localized Changes in Chromatin Architecture by Stimson, Krista M, Vertino, Paula M

“…Aberrant methylation of CpG-dense islands in the promoter regions of genes is an acquired epigenetic alteration associated with the silencing of tumor…”
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Isolation of polyadenylated RNA from cultured cells and intact tissues by Celano, P, Vertino, P M, Casero, Jr, R A

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