Search Results - "Verselis, Vytas K."

The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions by Sanchez, Helmuth A, Villone, Krista, Srinivas, Miduturu, Verselis, Vytas K

“…Mutations in the GJB2 gene, which encodes Cx26, are the most common cause of sensorineural deafness. In syndromic cases, such as keratitis-ichthyosis-deafness…”
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Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating by Verselis, Vytas K, Srinivas, Miduturu

“…Connexin hemichannels are robustly regulated by voltage and divalent cations. The basis of voltage-dependent gating, however, has been questioned with reports…”
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Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss by Sanchez, Helmuth A, Verselis, Vytas K

“…Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss…”
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The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular Magnesium Ions by Kraujalis, Tadas, Gudaitis, Lukas, Kraujaliene, Lina, Snipas, Mindaugas, Palacios-Prado, Nicolás, Verselis, Vytas K

“…Electrical synapses between neurons in the mammalian CNS are predominantly formed of the connexin36 (Cx36) gap junction (GJ) channel protein. Unique among GJs…”
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Loop Gating of Connexin Hemichannels Involves Movement of Pore-lining Residues in the First Extracellular Loop Domain by Verselis, Vytas K., Trelles, Maria P., Rubinos, Clio, Bargiello, Thaddeus A., Srinivas, Miduturu

“…Unapposed connexin hemichannels exhibit robust closure in response to membrane hyperpolarization and extracellular calcium. This form of gating, termed “loop…”
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Gating Properties of Heterotypic Gap Junction Channels Formed of Connexins 40, 43, and 45 by Rackauskas, Mindaugas, Kreuzberg, Maria M., Pranevicius, Mindaugas, Willecke, Klaus, Verselis, Vytas K., Bukauskas, Feliksas F.

“…Connexins (Cxs) 40, 43, and 45 are expressed in many different tissues, but most abundantly in the heart, blood vessels, and the nervous system. We examined…”
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Connexin hemichannels and cochlear function by Verselis, Vytas K.

“…•Connexin hemichannels have been proposed to play multiple roles in developing and mature cochlea.•Principal actions of hemichannels in the sensory epithelium…”
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Human diseases associated with connexin mutations by Srinivas, Miduturu, Verselis, Vytas K., White, Thomas W.

“…Gap junctions and hemichannels comprised of connexins impact many cellular processes. Significant advances in our understanding of the functional role of these…”
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Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel by Tang, Qingxiu, Dowd, Terry L, Verselis, Vytas K, Bargiello, Thaddeus A

“…The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed…”
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Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel by Oh, Seunghoon, Verselis, Vytas K., Bargiello, Thaddeus A.

“…Previous studies have shown that charge substitutions in the amino terminus of a chimeric connexin, Cx32*43E1, which forms unapposed hemichannels in Xenopus…”
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Functional Properties of Mouse Connexin30.2 Expressed in the Conduction System of the Heart by Kreuzberg, Maria M, Söhl, Goran, Kim, Jung-Sun, Verselis, Vytas K, Willecke, Klaus, Bukauskas, Feliksas F

“…Gap junction channels composed of connexin (Cx) 40, Cx43, and Cx45 proteins are known to be necessary for impulse propagation through the heart. Here, we…”
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Properties of Mouse Connexin 30.2 and Human Connexin 31.9 Hemichannels: Implications for Atrioventricular Conduction in the Heart by Bukauskas, Feliksas F., Kreuzberg, Maria M., Rackauskas, Mindaugas, Bukauskiene, Angele, Bennett, Michael V. L., Verselis, Vytas K., Willecke, Klaus

“…Four connexins (Cxs), mouse (m)Cx30.2, Cx40, Cx43, and Cx45, determine cell-cell electrical signaling in mouse heart, and Cx43 and Cx45 are known to form…”
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A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function by Sanchez, Helmuth A, Kraujaliene, Lina, Verselis, Vytas K

“…Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate intercellular and transmembrane signaling, respectively. Here, we…”
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An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities by Kraujaliene, Lina, Kraujalis, Tadas, Snipas, Mindaugas, Verselis, Vytas K

“…Two closely related connexins, Cx26 and Cx30, share widespread expression in the cochlear cellular networks. Gap junction channels formed by these connexins…”
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Modeling and analysis of voltage gating of gap junction channels at a single-channel level by Snipas, Mindaugas, Gudaitis, Lukas, Kraujaliene, Lina, Kraujalis, Tadas, Verselis, Vytas K.

“…The advancement of single-channel-level recording via the patch-clamp technique has provided a powerful means of assessing the detailed behaviors of various…”
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Connexin channel modulators and their mechanisms of action by Verselis, Vytas K., Srinivas, Miduturu

“…Gap junction channels and hemichannels formed by the connexin family of proteins play important roles in many aspects of tissue homeostasis in the brain and in…”
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Correlative Studies of Gating in Cx46 and Cx50 Hemichannels and Gap Junction Channels by Srinivas, Miduturu, Kronengold, Jack, Bukauskas, Feliksas F., Bargiello, Thaddeus A., Verselis, Vytas K.

“…Transjunctional voltage (Vj) gating of gap junction (GJ) channels formed of connexins has been proposed to occur by gating of the component hemichannels. We…”
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Regulation of connexin hemichannels by monovalent cations by Srinivas, Miduturu, Calderon, D Paola, Kronengold, Jack, Verselis, Vytas K

“…Opening of connexin hemichannels in the plasma membrane is highly regulated. Generally, depolarization and reduced extracellular Ca2+ promote hemichannel…”
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Coupling Asymmetry of Heterotypic Connexin 45/Connexin 43-EGFP Gap Junctions: Properties of Fast and Slow Gating Mechanisms by Bukauskas, Feliksas F., Angele, A. Bukauskiene, Verselis, Vytas K., Michael V. L. Bennett

“…Although fast and slow gating mechanisms have been described in gap junctions (GJs), their relative contributions to dependence on transjunctional voltage, Vj,…”
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Four-State Model for Simulating Kinetic and Steady-State Voltage-Dependent Gating of Gap Junctions by Snipas, Mindaugas, Kraujalis, Tadas, Maciunas, Kestutis, Kraujaliene, Lina, Gudaitis, Lukas, Verselis, Vytas K.

“…Gap junction (GJ) channels, formed of connexin (Cx) proteins, provide a direct pathway for metabolic and electrical cell-to-cell communication. These…”
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