Search Results - "Verschuren, EW"

The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin by Verschuren, Emmy W, Jones, Nic, Evan, Gerard I

“…1 Stanford University, Pathology Department, 300 Pasteur Drive, MC 5324, Stanford, CA 94305, USA 2 Paterson Institute for Cancer Research, Christie Hospital…”
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Extendable blocking probe in reverse transcription for analysis of RNA variants with superior selectivity by Ho, Tho H, Dang, Kien X, Lintula, Susanna, Hotakainen, Kristina, Feng, Lin, Olkkonen, Vesa M, Verschuren, Emmy W, Tenkanen, Tuomas, Haglund, Caj, Kolho, Kaija-Leena, Stenman, Ulf-Hakan, Stenman, Jakob

“…Here we provide the first strategy to use a competitive Extendable Blocking Probe (ExBP) for allele-specific priming with superior selectivity at the stage of…”
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Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1 by Nagaraj, Ashwini S., Lahtela, Jenni, Hemmes, Annabrita, Pellinen, Teijo, Blom, Sami, Devlin, Jennifer R., Salmenkivi, Kaisa, Kallioniemi, Olli, Mäyränpää, Mikko I., Närhi, Katja, Verschuren, Emmy W.

“…Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Närhi, Katja, Nagaraj, Ashwini S, Parri, Elina, Turkki, Riku, van Duijn, Petra W, Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I, Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M, Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W

“…A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial…”
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Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer by Bao, Jie, Walliander, Margarita, Kovács, Ferenc, Nagaraj, Ashwini S., Hemmes, Annabrita, Sarhadi, Virinder Kaur, Knuutila, Sakari, Lundin, Johan, Horvath, Peter, Verschuren, Emmy W.

“…To facilitate analysis of spatial tissue phenotypes, we created an open-source tool package named ‘Spa-RQ’ for ‘Spatial tissue analysis: image Registration &…”
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Temporal dissection of p53 function in vitro and in vivo by Evan, Gerard I, Christophorou, Maria A, Martin-Zanca, Dionisio, Soucek, Laura, Lawlor, Elizabeth R, Brown-Swigart, Lamorna, Verschuren, Emmy W

“…To investigate the functions of the p53 tumor suppressor, we created a new knock-in gene replacement mouse model in which the endogenous Trp53 gene is…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Narhi, K, Nagaraj, AS, Parri, E, Turkki, R, van Duijn, PW, Hemmes, A, Lahtela, J, Uotinen, V, Mayranpaa, MI, Salmenkivi, K, Rasanen, J, Linder, N, Trapman, J, Rannikko, A, Kallioniemi, O, Af Hallstrom, TM, Lundin, J, Sommergruber, W, Anders, S, Verschuren, EW

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The Evi5 Oncogene Regulates Cyclin Accumulation by Stabilizing the Anaphase-Promoting Complex Inhibitor Emi1 by Eldridge, Adam G., Loktev, Alexander V., Hansen, David V., Verschuren, Emmy W., Reimann, Julie D.R., Jackson, Peter K.

“…The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to S phase and mitosis by stabilizing key APC/C ubiquitination substrates,…”
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The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo by Verschuren, Emmy W., Klefstrom, Juha, Evan, Gerard I., Jones, Nic

“…Expression of the Kaposi's sarcoma-associated herpesvirus (KSHV) cyclin D homolog, K cyclin, is thought to contribute to viral oncogenesis. We show that K…”
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Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice by Kakkola, L, Denisova, O V, Tynell, J, Viiliäinen, J, Ysenbaert, T, Matos, R C, Nagaraj, A, Öhman, T, Kuivanen, S, Paavilainen, H, Feng, L, Yadav, B, Julkunen, I, Vapalahti, O, Hukkanen, V, Stenman, J, Aittokallio, T, Verschuren, E W, Ojala, P M, Nyman, T, Saelens, X, Dzeyk, K, Kainov, D E

“…ABT-263 and its structural analogues ABT-199 and ABT-737 inhibit B-cell lymphoma 2 (Bcl-2), BCL2L1 long isoform (Bcl-xL) and BCL2L2 (Bcl-w) proteins and…”
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c-Myc Augments the Apoptotic Activity of Cytosolic Death Receptor Signaling Proteins by Engaging the Mitochondrial Apoptotic Pathway by Klefstrom, Juha, Verschuren, Emmy W, Evan, Gerard

“…Activation of c-Myc sensitizes cells to apoptosis induction by ligand-activated death receptors. Such sensitization to death receptors by oncogenes may well be…”
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The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis by VERSCHUREN, Emmy W, HODGSON, J. Graeme, GRAY, Joe W, KOGAN, Scott, JONES, Nic, EVAN, Gerard I

“…Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cyclin D homolog, K cyclin, that is thought to promote viral oncogenesis. However, expression of K…”
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The Evi5 Oncogene Regulates Cyclin Accumulation by Stabilizing the Anaphase-Promoting Complex Inhibitor Emi1 by Eldridge, Adam G., Loktev, Alexander V., Hansen, David V., Verschuren, Emmy W., Reimann, Julie D.R., Jackson, Peter K.

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Interleukin-7 Upregulates the Interleukin-2–Gene Expression in Activated Human T Lymphocytes at the Transcriptional Level by Enhancing the DNA Binding Activities of Both Nuclear Factor of Activated T Cells and Activator Protein-1 by Gringhuis, Sonja I., F.M.H. de Leij, Lou, Verschuren, Emmy W., Borger, Peter, Vellenga, Edo

“…In the present report, we studied the role of the stromal-derived cytokine interleukin-7 (IL-7) in the IL-2–gene regulation in activated T lymphocytes…”
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