Search Results - "Verschoyle, Richard D."

Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice by ANDERTON, Mark J, MANSON, Margaret M, VERSCHOYLE, Richard D, GESCHER, Andreas, LAMB, John H, FARMER, Peter B, STEWARD, William P, WILLIAMS, Marion L

“…Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are promising cancer chemopreventive agents in rodent models, but there is a paucity of data on their…”
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Chemopreventive Efficacy and Pharmacokinetics of Curcumin in the Min/+ Mouse, a Model of Familial Adenomatous Polyposis by PERKINS, Sarah, VERSCHOYLE, Richard D, HILL, Kirsti, PARVEEN, Ifat, THREADGILL, Michael D, SHARMA, Ricky A, WILLIAMS, Marion L, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human…”
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Simultaneous determination of 8-oxo-2′-deoxyguanosine and 8-oxo-2′-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry by Singh, Rajinder, Teichert, Friederike, Verschoyle, Richard D., Kaur, Balvinder, Vives, Montserrat, Sharma, Ricky A., Steward, William P., Gescher, Andreas J., Farmer, Peter B.

“…Sensitive and reliable methods are required for the assessment of oxidative DNA damage, which can result from reactive oxygen species that are generated…”
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Determination of 8-oxo-2′-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies by Teichert, Friederike, Verschoyle, Richard D., Greaves, Peter, Thorpe, James F., Mellon, J. Kilian, Steward, William P., Farmer, Peter B., Gescher, Andreas J., Singh, Rajinder

“…Urinary 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG) represents a non‐invasive biomarker for oxidative stress and may be useful for monitoring…”
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Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone by VERSCHOYLE, Richard D, GREAVES, Peter, GESCHER, Andreas J, HONG CAI, BORKHARDT, Arndt, BROGGINI, Massimo, D'INCALCI, Maurizio, RICCIO, Ed, DOPPALAPUDI, Rupa, KAPETANOVIC, Izet M, STEWARD, William P

“…Naturally occurring flavonoids such as quercetin and genistein possess cancer chemopreventive properties in experimental models. However, adverse effects such…”
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Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo by Pathak, Sanjeev, Singh, Rajinder, Verschoyle, Richard D, Greaves, Peter, Farmer, Peter B, Steward, William P, Mellon, J. Kilian, Gescher, Andreas J, Sharma, Ricky A

“…Abstract Intracellular reactive oxygen species (ROS) may cause oxidative DNA damage, resulting in the formation of adducts such as…”
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Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine by MARCZYLO, Timothy H, VERSCHOYLE, Richard D, COOKE, Darren N, MORAZZONI, Paolo, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, a major constituent of the spice turmeric, suppresses expression of the enzyme cyclooxygenase 2 (Cox-2) and has cancer chemopreventive properties in…”
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A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3′- O-sulfate as a urinary metabolite in the rat by Jones, Donald J.L., Jukes-Jones, Rebekah, Verschoyle, Richard D., Farmer, Peter B., Gescher, Andreas

“…The synthesis and characterization of quercetin sulfate isomers, which are putative metabolites of quercetin, are described herein. To study the biological…”
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Putative cancer chemopreventive agents of dietary origin-how safe are they? by Verschoyle, R.D, Steward, W.P, Gescher, A.J

“…As cancer chemopreventive agents are intended for use by healthy individuals as prophylactics to prevent or retard the development of cancer, they must be…”
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Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa : Relationship with drug levels by SHARMA, Ricky A, IRESON, Christopher R, VERSCHOYLE, Richard D, HILL, Kirsti A, WILLIAMS, Marion L, LEURATTI, Chiara, MANSON, Margaret M, MARNETT, Lawrence J, STEWARD, William P, GESCHER, Andreas

“…Curcumin prevents colon cancer in rodent models. It inhibits lipid peroxidation and cyclooxygenase-2 (COX-2) expression and induces glutathione S-transferase…”
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Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels by Verschoyle, Richard D, Greaves, Peter, Patel, Ketan, Marsden, Debbie A, Brown, Karen, Steward, William P, Gescher, Andreas J

“…Abstract Silibinin, a flavonolignan from milk thistle seeds, possesses cancer chemopreventive properties in rodent models of carcinogenesis. We tested the…”
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Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse by Verschoyle, Richard D., Brown, Karen, Steward, William P., Gescher, Andreas J.

“…Silibinin is a flavonolignan extracted from milk thistle with cancer chemopreventive activity in preclinical models of prostate and colorectal cancer. A milk…”
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Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat by DONALD, Sarah, VERSCHOYLE, Richard D, RICCARDI, Riccardo, LOPEZ-LAZARO, Luis, JIMENO, Jose, GESCHER, Andreas J, GREAVES, Peter, GANT, Timothy W, COLOMBO, Tina, ZAFFARONI, Marco, FRAPOLLI, Roberta, ZUCCHETTI, Massimo, D'INCALCI, Maurizio, MECO, Daniela

“…Yondelis (ET-743) is a promising antitumor drug with hepatotoxic properties in animals and humans. Here the hypothesis was tested that dexamethasone can…”
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Cytotoxic action of phorbol esters on human pancreatic cancer cells by Bond, Jane A., Gescher, Andreas J., Verschoyle, Richard D., Lemoine, Nicholas R., Errington, Rachel, Wiltshire, Marie, Smith, Paul J., Wynford‐Thomas, David

“…We previously showed that phorbol esters are cytotoxic to human thyroid epithelial cells expressing a mutant RAS oncogene. Here we explore the generality of…”
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Dietary agent indole‐3‐carbinol protects female rats against the hepatotoxicity of the antitumor drug ET‐743 (trabectidin) without compromising efficacy in a rat mammary carcinoma by Donald, Sarah, Verschoyle, Richard D., Greaves, Peter, Colombo, Tina, Zucchetti, Massimo, Falcioni, Cristiano, Zaffaroni, Marco, D'Incalci, Maurizio, Manson, Margaret M., Jimeno, Jose, Steward, William P., Gescher, Andreas J.

“…ET‐743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is…”
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Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer by Teichert, Friederike, Verschoyle, Richard D, Greaves, Peter, Jones, Donald J L, Wilson, Ian D, Farmer, Peter B, Steward, William P, Gescher, Andreas J, Keun, Hector C

“…Green tea polyphenols (GTP) have been widely investigated for their potential to prevent prostate cancer. However, results from epidemiological and clinical…”
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Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) Tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism by Teichert, Friederike, Verschoyle, Richard D., Greaves, Peter, Edwards, Richard E., Teahan, Orla, Jones, Donald J.L., Wilson, Ian D., Farmer, Peter B., Steward, William P., Gant, Timothy W., Gescher, Andreas J., Keun, Hector C.

“…BACKGROUND The TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mouse model has frequently been used in preclinical studies with…”
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Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat by DONALD, Sarah, VERSCHOYLE, Richard D, GREAVES, Peter, GESCHER, Andreas J, EDWARDS, Richard, JUDAH, David J, DAVIES, Reginald, RILEY, Joan, DINSDALE, David, LOPEZ LAZARO, Luis, SMITH, Andrew G, GANT, Timothy W

“…Ecteinascidin-743 (ET-743) is a novel marine-derived anticancer drug with clinical activity in soft tissue sarcoma and ovarian cancer. Reversible transaminitis…”
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Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro by DONALD, Sarah, VERSCHOYLE, Richard D, GREAVES, Peter, ORR, Samantha, JIMENO, Jose, GESCHER, Andreas J

“…Yondelis (ET-743), a tetrahydroisoquinoline alkaloid isolated from a marine tunicate, is a novel drug with demonstrated anticancer activity in early clinical…”
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Cell-specific loss of cytochrome P450 2B1 in rat lung following treatment with pneumotoxic and non-pneumotoxic trialkylphosphorothioates by Dinsdale, David, Verschoyle, Richard D.

“…This study was designed to test the hypothesis that the reduction in cytochrome P450 (CYP) 2B1 content and activity of rat lung microsomes, following dosing…”
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