A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

Over the last 2 decades, affirmative diagnoses of osteoarthritis (OA) in the United States have tripled due to increasing rates of obesity and an aging population. Hemp-derived cannabidiol (CBD) is the major nontetrahydrocannabinol component of cannabis and has been promoted as a potential treatment...

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Bibliographic Details
Published in:	Pain (Amsterdam) Vol. 161; no. 9; pp. 2191 - 2202
Main Authors:	Verrico, Chris D., Wesson, Shonda, Konduri, Vanaja, Hofferek, Colby J., Vazquez-Perez, Jonathan, Blair, Emek, Dunner, Kenneth, Salimpour, Pedram, Decker, William K., Halpert, Matthew M.
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer 01-09-2020
Subjects:	Animals Arthralgia - drug therapy Arthralgia - veterinary Cannabidiol - therapeutic use Cannabis Disease Models, Animal Dog Diseases - drug therapy Dogs Double-Blind Method Mice Osteoarthritis - complications Osteoarthritis - drug therapy Osteoarthritis - veterinary
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Summary:	Over the last 2 decades, affirmative diagnoses of osteoarthritis (OA) in the United States have tripled due to increasing rates of obesity and an aging population. Hemp-derived cannabidiol (CBD) is the major nontetrahydrocannabinol component of cannabis and has been promoted as a potential treatment for a wide variety of disparate inflammatory conditions. Here, we evaluated CBD for its ability to modulate the production of proinflammatory cytokines in vitro and in murine models of induced inflammation and further validated the ability of a liposomal formulation to increase bioavailability in mice and in humans. Subsequently, the therapeutic potential of both naked and liposomally encapsulated CBD was explored in a 4-week, randomized placebo-controlled, double-blinded study in a spontaneous canine model of OA. In vitro and in mouse models, CBD significantly attenuated the production of proinflammatory cytokines IL-6 and TNF-α while elevating levels of anti-inflammatory IL-10. In the veterinary study, CBD significantly decreased pain and increased mobility in a dose-dependent fashion among animals with an affirmative diagnosis of OA. Liposomal CBD (20 mg/day) was as effective as the highest dose of nonliposomal CBD (50 mg/day) in improving clinical outcomes. Hematocrit, comprehensive metabolic profile, and clinical chemistry indicated no significant detrimental impact of CBD administration over the 4-week analysis period. This study supports the safety and therapeutic potential of hemp-derived CBD for relieving arthritic pain and suggests follow-up investigations in humans are warranted.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Authors’ Contributions These authors contributed equally to the preparation of this manuscript CDV wrote the paper and analyzed data. SW designed and performed experiments, analyzed data, and contributed critical research tools. VK analyzed data. CH performed experiments. JV-P performed experiments. EB designed and performed experiments, analyzed data, and contributed critical research tools. KD analyzed data. PS analyzed data and provided critical research tools. WKD analyzed data, wrote the paper, and provided critical research tools. MMH designed and performed experiments, analyzed data, wrote the paper, and provided critical research tools.
ISSN:	0304-3959 1872-6623
DOI:	10.1097/j.pain.0000000000001896