Search Results - "Verrax, J."

Role of oxidative stress in the pathogenesis of alcohol-induced liver disease by Sid, B, Verrax, J, Calderon, P B

“…Chronic alcohol consumption is a well-known risk factor for liver disease, which represents a major cause of morbidity and mortality worldwide. The…”
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Gut microbiota-derived propionate reduces cancer cell proliferation in the liver by Bindels, L B, Porporato, P, Dewulf, E M, Verrax, J, Neyrinck, A M, Martin, J C, Scott, K P, Buc Calderon, P, Feron, O, Muccioli, G G, Sonveaux, P, Cani, P D, Delzenne, N M

“…Background: Metabolites released by the gut microbiota may influence host metabolism and immunity. We have tested the hypothesis that inulin-type fructans…”
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Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells by Valenzuela, M, Glorieux, C, Stockis, J, Sid, B, Sandoval, J M, Felipe, K B, Kviecinski, M R, Verrax, J, Calderon, P Buc

“…Background: Standard therapy for acute promyelocytic leukaemia (APL) includes retinoic acid (all- trans retinoic acid (ATRA)), which promotes differentiation…”
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The controversial place of vitamin C in cancer treatment by Verrax, J., Buc Calderon, P.

“…In 2008, we celebrate the 80th anniversary of the discovery of vitamin C. Since then, we know that vitamin C possesses few pharmacological actions although it…”
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In situ modulation of oxidative stress: a novel and efficient strategy to kill cancer cells by Verrax, J, Pedrosa, R Curi, Beck, R, Dejeans, N, Taper, H, Calderon, P Buc

“…Cancer cells show an up-regulation of glycolysis, they readily take up vitamin C, and they appear more susceptible to an oxidative stress than the surrounding…”
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Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells by Kviecinski, M.R., Pedrosa, R.C., Felipe, K.B., Farias, M.S., Glorieux, C., Valenzuela, M., Sid, B., Benites, J., Valderrama, J.A., Verrax, J., Buc Calderon, P.

“…[Display omitted] ► The cytotoxicity of juglone is markedly increased by ascorbate. ► T24 cell death by oxidative stress is necrosis-like. ► Redox cycling by…”
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Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies by Beck, R, Dejeans, N, Glorieux, C, Pedrosa, R C, Vásquez, D, Valderrama, J A, Calderon, P B, Verrax, J

“…Hsp90 is a molecular chaperone involved in the stabilization of many oncoproteins that are required for the acquisition and maintenance of the so-called six…”
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Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells by Felipe, K.B., Benites, J., Glorieux, C., Sid, B., Valenzuela, M., Kviecinski, M.R., Pedrosa, R.C., Valderrama, J.A., Levêque, Ph, Gallez, B., Verrax, J., Buc Calderon, P.

“…•Phenylaminonaphthoquinones are redox cyclers able to form ROS.•Phenylaminonaphthoquinones plus ascorbate inhibit T24 cell growth.•Phenylaminonaphthoquinones…”
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388 Photodynamic Therapy Mediated by Hypericin, a Natural Endoplasmic Reticulum-localized Drug, Activates Autophagic Pathways That Increase the Resistance to the Therapy by Rubio, N, Verrax, J, Dewaele, M, Piette, J, Agostinis, P

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Redox-active quinones and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress by Verrax, J, Beck, R, Dejeans, N, Glorieux, C, Sid, B, Pedrosa, R Curi, Benites, J, Vásquez, D, Valderrama, J A, Calderon, P Buc

“…Cancer cells are particularly vulnerable to treatments impairing redox homeostasis. Reactive oxygen species (ROS) can indeed play an important role in the…”
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Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death by Verrax, Julien, Cadrobbi, Julie, Marques, Carole, Taper, Henryk, Habraken, Yvette, Piette, Jacques, Calderon, Pedro Buck

“…Hepatocarcinoma cells (TLT) were incubated in the presence of ascorbate and menadione, either alone or in combination. Cell death was only observed when such…”
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Botulinum toxin potentiates cancer radiotherapy and chemotherapy by ANSIAUX, Réginald, BAUDELET, Christine, GREGOIRE, Vincent, BUC CALDERON, Pedro, FERON, Olivier, GALLEZ, Bernard, CRON, Greg O, SEGERS, Jérome, DESSY, Chantal, MARTINIVE, Philippe, DE WEVER, Julie, VERRAX, Julien, WAUTHIER, Valérie, BEGHEIN, Nelson

“…PURPOSE: Structural and functional abnormalities in the tumor vascular network are considered factors of resistance of solid tumors to cytotoxic treatments. To…”
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Targeting cancer cells by an oxidant-based therapy by Verrax, J, Taper, H, Buc Calderon, P

“…Despite the progress achieved in chemo- and radiotherapy, cancer is still a leading life-threatening pathology. In that sense, there is a need for novel…”
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The association of vitamins C and K 3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy by Verrax, Julien, Cadrobbi, Julie, Delvaux, Marianne, Jamison, James M., Gilloteaux, Jacques, Summers, Jack L., Taper, Henryk S., Buc Calderon, Pedro

“…Deficiency of alkaline and acid DNase is a hallmark in all non-necrotic cancer cells in animals and humans. These enzymes are reactivated at early stages of…”
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