Search Results - "Veronese, Francesco M"

State of the art in PEGylation: The great versatility achieved after forty years of research by Pasut, Gianfranco, Veronese, Francesco M.

“…In the recent years, protein PEGylation has become an established and highly refined technology by moving forward from initial simple random coupling…”
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The Impact of PEGylation on Biological Therapies by Veronese, Francesco M., Mero, Anna

“…The term PEGylation describes the modification of biological molecules by covalent conjugation with polyethylene glycol (PEG), a non-toxic, non-immunogenic…”
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Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery by Viegas, Tacey X, Bentley, Michael D, Harris, J. Milton, Fang, Zhihao, Yoon, Kunsang, Dizman, Bekir, Weimer, Rebecca, Mero, Anna, Pasut, Gianfranco, Veronese, Francesco M

“…Polyoxazoline polymers with methyl (PMOZ), ethyl (PEOZ), and propyl (PPOZ) side chains were prepared by the living cationic polymerization method and purified…”
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Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase by Fontana, Angelo, Spolaore, Barbara, Mero, Anna, Veronese, Francesco M.

“…Transglutaminase (TGase, E.C. 2.3.2.13) catalyzes acyl transfer reactions between the γ-carboxamide groups of protein-bound glutamine (Gln) residues, which…”
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A new method to increase selectivity of transglutaminase mediated PEGylation of salmon calcitonin and human growth hormone by Mero, Anna, Schiavon, Mariano, Veronese, Francesco M., Pasut, Gianfranco

“…Modification of therapeutic proteins and peptides by polyethylene glycol (PEG) conjugation is a well-known approach to improve the pharmacological properties…”
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Antitumoral activity of PEG–gemcitabine prodrugs targeted by folic acid by Pasut, Gianfranco, Canal, Fabiana, Dalla Via, Lisa, Arpicco, Silvia, Veronese, Francesco M., Schiavon, Oddone

“…Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine (dFdC), is an antitumor agent effective in the treatment of several solid tumors but its use is hampered by short…”
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Peptide and protein PEGylation III: advances in chemistry and clinical applications by VERONESE, Francesco M, HARRIS, J. Milton

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Transglutaminase-Mediated PEGylation of Proteins: Direct Identification of the Sites of Protein Modification by Mass Spectrometry using a Novel Monodisperse PEG by Mero, Anna, Spolaore, Barbara, Veronese, Francesco M, Fontana, Angelo

“…Poly(ethylene glycol) (PEG) has been widely used to prolong the residence time of proteins in blood and to decrease their immunogenicity and antigenicity. A…”
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PEG−Doxorubicin Conjugates:  Influence of Polymer Structure on Drug Release, in Vitro Cytotoxicity, Biodistribution, and Antitumor Activity by Veronese, Francesco M, Schiavon, Oddone, Pasut, Gianfranco, Mendichi, Raniero, Andersson, Lars, Tsirk, Anders, Ford, Jayne, Wu, Gefei, Kneller, Samantha, Davies, John, Duncan, Ruth

“…Polymer−drug conjugates (polymer therapeutics) are finding increasing use as novel anticancer agents. Here a series of poly(ethylene glycol) PEG−doxorubicin…”
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PEG conjugates in clinical development or use as anticancer agents: An overview by Pasut, Gianfranco, Veronese, Francesco M.

“…During the almost forty years of PEGylation, several antitumour agents, either proteins, peptides or low molecular weight drugs, have been considered for…”
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Polymer−Drug Conjugates for Combination Anticancer Therapy: Investigating the Mechanism of Action by Pasut, Gianfranco, Greco, Francesca, Mero, Anna, Mendichi, Raniero, Fante, Cristina, Green, Rebecca J, Veronese, Francesco M

“…We developed a family of polymer−drug conjugates carrying the combination of the anticancer agent epirubicin (EPI) and nitric oxide (NO). EPI-PEG-(NO)8,…”
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PEGylation, successful approach to drug delivery by Veronese, Francesco M., Pasut, Gianfranco

“…An overview of PEGylation, from its basic strategies of conjugation to the recent achievements and therapeutic applications. PEGylation defines the…”
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Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates by Caliceti, Paolo, Veronese, Francesco M.

“…Peptide and protein PEGylation is usually undertaken to improve the biopharmaceutical properties of these drugs and, to date, several examples of conjugates…”
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Anti-cancer PEG-enzymes: 30 years old, but still a current approach by Pasut, Gianfranco, Sergi, Mauro, Veronese, Francesco M.

“…PEGylation (i.e. the covalent link of PEG strands) is a well known technique used to improve pharmaceutical properties of bioactive proteins and peptides. Even…”
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Peptide and protein PEGylation: a review of problems and solutions by Veronese, Francesco M

“…The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Methods of binding PEG to different functional…”
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Selective conjugation of poly(2-ethyl 2-oxazoline) to granulocyte colony stimulating factor by Mero, Anna, Fang, Zhihao, Pasut, Gianfranco, Veronese, Francesco M., Viegas, Tacey X.

“…Poly(2-ethyl 2-oxazoline) (PEOZ) is a water-soluble, stable and biocompatible polymer that was prepared in a linear form for the conjugation of protein…”
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Immunological Properties of Uricase Conjugated to Neutral Soluble Polymers by Caliceti, Paolo, Schiavon, Oddone, Veronese, Francesco M

“…For a comparative study of immunological properties of protein−polymer conjugates, uricase was modified with (a) poly(N-vinylpyrrolidone) 6000 Da, (b)…”
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Preparation and Characterization of Poly(ethylene glycol) Vinyl Sulfone by Morpurgo, Margherita, Veronese, Francesco M, Kachensky, David, Harris, J. Milton

“…Synthesis of the vinyl sulfone and chloroethyl sulfone derivatives of poly(ethylene glycol) (PEG) is described. The chloroethyl sulfone (CES-PEG) is rapidly…”
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Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice by Santucci, Luca, Mencarelli, Andrea, Renga, Barbara, Ceccobelli, Daniela, Pasut, Gianfranco, Veronese, Francesco M, Distrutti, Eleonora, Fiorucci, Stefano

“…The use of epirubicin is limited by the risk of a dilatory congestive heart failure that develops as a consequence of induction of a mitochondrial-dependent…”
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Site-Specific Pegylation of G-CSF by Reversible Denaturation by Veronese, Francesco M, Mero, Anna, Caboi, Francesca, Sergi, Mauro, Marongiu, Christian, Pasut, Gianfranco

“…A new strategy has been developed for extending the possibility of poly(ethylene glycol) (PEG) modification to accessible thiol groups of biologically active…”
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