Search Results - "Vernon, Tyler L."

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction by Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Nasrallah, Nawar Al, Garrett, Joy, Turchi, John J

“…Abstract DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage response (DDR)…”
Get full text

Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein–DNA Interaction by Gavande, Navnath S, VanderVere-Carozza, Pamela, Mishra, Akaash K, Vernon, Tyler L, Pawelczak, Katherine S, Turchi, John J

“…XPA is a unique and essential protein required for the nucleotide excision DNA repair pathway and represents a therapeutic target in oncology. Herein, we are…”
Get full text

Structure-Guided Optimization of Replication Protein A (RPA)–DNA Interaction Inhibitors by Gavande, Navnath S., VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Vernon, Tyler L., Jordan, Matthew R., Turchi, John J.

“…Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination,…”
Get full text

Abstract 1416: Development of small molecule inhibitors for cancer therapy by targeting RPA and XPA nucleotide excision repair proteins by Gavande, Navnath S., VanderVere-Carozza, Pamela S., Vernon, Tyler L., Pawelczak, Katherine, Turchi, John J.

“…Targeting DNA repair and the DNA damage response for cancer therapy has recently gained increasing attention with inhibitors of the PARP enzyme showing a…”
Get full text