Search Results - "Vernon, Robert B."

A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro by Evanko, Stephen P., Gooden, Michel D., Kang, Inkyung, Chan, Christina K., Vernon, Robert B., Wight, Thomas N.

“…Hyaluronan and proteoglycan link protein 1 (HAPLN1) stabilizes interactions between two important extracellular matrix (ECM) macromolecules, versican and…”
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The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain by Reed, May J., Damodarasamy, Mamatha, Pathan, Jasmine L., Erickson, Michelle A., Banks, William A., Vernon, Robert B.

“…The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised…”
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Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis by Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y, Gebe, John A, Preisinger, Anton, Falk, Ben A, Sunkari, Vivekananda G, Gooden, Michel D, Vernon, Robert B, Bogdani, Marika, Kuipers, Hedwich F, Day, Anthony J, Campbell, Daniel J, Wight, Thomas N, Bollyky, Paul L

“…We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients…”
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Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro by Bota, Paige C. S., Collie, Angela M. B., Puolakkainen, Pauli, Vernon, Robert B., Sage, E. Helene, Ratner, Buddy D., Stayton, Patrick S.

“…The effect of biomaterial topography on healing in vivo and monocyte/macrophage stimulation in vitro was assessed. A series of expanded polytetrafluoroethylene…”
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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors by Bollyky, Paul L., Wu, Rebecca P., Falk, Ben A., Lord, James D., Long, S. Alice, Preisinger, Anton, Teng, Brandon, Holt, Gregory E., Standifer, Nathan E., Braun, Kathleen R., Xie, Cindy Fang, Samuels, Peter L., Vernon, Robert B., Gebe, John A., Wight, Thomas N., Nepom, Gerald T., Germain, Ron

“…We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan…”
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The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA) by Damodarasamy, Mamatha, Vernon, Robert B, Pathan, Jasmine L, Keene, C Dirk, Day, Anthony J, Banks, William A, Reed, May J

“…The microvasculature (MV) of brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA), in the absence of concurrent…”
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Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft by Gebe, John A., Preisinger, Anton, Gooden, Michel D., D’Amico, Leonard A., Vernon, Robert B.

“…Islet transplantation remains the only alternative to daily insulin therapy for control of type 1 diabetes (T1D) in humans. To avoid the drawbacks of…”
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Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds by Damodarasamy, Mamatha, Johnson, Richard S., Bentov, Itay, MacCoss, Michael J., Vernon, Robert B., Reed, May J.

“…Age‐related changes in the extracellular matrix contribute to delayed wound repair in aging. Hyaluronan, a linear nonsulfated glycosaminoglycan, promotes…”
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Hymecromone Promotes Longevity and Insulin Sensitivity in Mice by Nagy, Nadine, Czepiel, Kathryn S, Kaber, Gernot, Stefanovski, Darko, Hargil, Aviv, Pennetzdorfer, Nina, Targ, Robert, Reghupaty, Saranya C, Wight, Thomas N, Vernon, Robert B, Hull-Meichle, Rebecca L, Marshall, Payton, Medina, Carlos O, Martinez, Hunter, Kalinowski, Anissa, Paladini, Rudolph D, Garantziotis, Stavros, Knowles, Joshua W, Bollyky, Paul L

“…Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA…”
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Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections by Kratochvil, Michael J, Kaber, Gernot, Demirdjian, Sally, Cai, Pamela C, Burgener, Elizabeth B, Nagy, Nadine, Barlow, Graham L, Popescu, Medeea, Nicolls, Mark R, Ozawa, Michael G, Regula, Donald P, Pacheco-Navarro, Ana E, Yang, Samuel, de Jesus Perez, Vinicio A, Karmouty-Quintana, Harry, Peters, Andrew M, Zhao, Bihong, Buja, Maximilian L, Johnson, Pamela Y, Vernon, Robert B, Wight, Thomas N, Milla, Carlos E, Rogers, Angela J, Spakowitz, Andrew J, Heilshorn, Sarah C, Bollyky, Paul L

“…Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly…”
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ADAMTS-4 and Biglycan are Expressed at High Levels and Co-Localize to Podosomes During Endothelial Cell Tubulogenesis In Vitro by Obika, Masanari, Vernon, Robert B., Gooden, Michel D., Braun, Kathleen R., Chan, Christina K., Wight, Thomas N.

“…Proteolysis of the extracellular matrix influences vascular growth. We examined the expression of ADAMTS-1, -4, and -5 metalloproteinases and their…”
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Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets by Gebe, John A., Gooden, Michel D., Workman, Gail, Nagy, Nadine, Bollyky, Paul L., Wight, Thomas N., Vernon, Robert B.

“…The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays…”
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Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor by Robert B. Vernon, Anton Preisinger, Michel D. Gooden, Leonard A. D'amico, Betty B. Yue, Paul L. Bollyky, Christian S. Kuhr, Thomas R. Hefty, Gerald T. Nepom, John A. Gebe Ph.D.

“…We have developed a bioengineered implant (BI) to evaluate strategies to promote graft survival and function in models of islet transplantation in mice. The…”
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Targeting the Extracellular Matrix Promotes Healing Following Myocardial Infarction by Wight, Thomas N, Vernon, Robert B

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Autocrine Hyaluronan Influences Sprouting and Lumen Formation During HUVEC Tubulogenesis In Vitro by Vernon, Robert B., Gooden, Michel D., Chan, Christina K., Workman, Gail, Obika, Masanari, Wight, Thomas N.

“…Although many studies have focused on a role for hyaluronan (HA) of interstitial extracellular matrix (presumably produced by non-vascular “stromal” cells) in…”
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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Bollyky, Paul L., Vernon, Robert B., Falk, Ben A., Preisinger, Anton, Gooden, Michel D., Nepom, Gerald T., Gebe, John A.

“…Local induction of pro-tolerogenic cytokines, such as IL-10, is an appealing strategy to help facilitate transplantation of islets and other tissues. Here, we…”
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Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging by Reed, May J, Vernon, Robert B, Damodarasamy, Mamatha, Chan, Christina K, Wight, Thomas N, Bentov, Itay, Banks, William A

“…The microvasculature of the aged brain is less dense and more vulnerable to dysfunction than that of the young brain. Brain microvasculature is supported by…”
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Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease by Reed, May J, Damodarasamy, Mamatha, Pathan, Jasmine L, Chan, Christina K, Spiekerman, Charles, Wight, Thomas N, Banks, William A, Day, Anthony J, Vernon, Robert B, Keene, C Dirk

“…Little is known about the extracellular matrix (ECM) during progression of AD pathology. Brain ECM is abundant in hyaluronan (HA), a non-sulfated…”
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Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection by Marshall, Payton L., Nagy, Nadine, Kaber, Gernot, Barlow, Graham L., Ramesh, Amrit, Xie, Bryan J., Linde, Miles H., Haddock, Naomi L., Lester, Colin A., Tran, Quynh-Lam, de Vries, Christiaan R., Hargil, Aviv, Malkovskiy, Andrey V., Gurevich, Irina, Martinez, Hunter A., Kuipers, Hedwich F., Yadava, Koshika, Zhang, Xiangyue, Evanko, Stephen P., Gebe, John A., Wang, Xi, Vernon, Robert B., de la Motte, Carol, Wight, Thomas N., Engleman, Edgar G., Krams, Sheri M., Meyer, Everett H., Bollyky, Paul L.

“…•Hyaluronan (HA) is deposited in inflamed lymph nodes by antigen presenting cells.•Inhibition of HA prevents inflammatory T-cell activation and promotes FoxP3+…”
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Overexpression of Decorin by Rat Arterial Smooth Muscle Cells Enhances Contraction of Type I Collagen In Vitro by Järveläinen, Hannu, Vernon, Robert B, Gooden, Michel D, Francki, Aleksandar, Lara, Stephanie, Johnson, Pamela Y, Kinsella, Michael G, Sage, E Helene, Wight, Thomas N

“…OBJECTIVE—Overexpression of decorin reduces neointimal thickening in balloon-injured carotid arteries of rats by decreasing the volume of neointimal…”
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