Search Results - "Vernon, Katherine"

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation by Subramanian, Ayshwarya, Sidhom, Eriene-Heidi, Emani, Maheswarareddy, Vernon, Katherine, Sahakian, Nareh, Zhou, Yiming, Kost-Alimova, Maria, Slyper, Michal, Waldman, Julia, Dionne, Danielle, Nguyen, Lan T., Weins, Astrid, Marshall, Jamie L., Rosenblatt-Rosen, Orit, Regev, Aviv, Greka, Anna

“…Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and…”
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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model by Suzzi, Stefano, Croese, Tommaso, Ravid, Adi, Gold, Or, Clark, Abbe R., Medina, Sedi, Kitsberg, Daniel, Adam, Miriam, Vernon, Katherine A., Kohnert, Eva, Shapira, Inbar, Malitsky, Sergey, Itkin, Maxim, Brandis, Alexander, Mehlman, Tevie, Salame, Tomer M., Colaiuta, Sarah P., Cahalon, Liora, Slyper, Michal, Greka, Anna, Habib, Naomi, Schwartz, Michal

“…Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on systemic immunity. Independently, obesity was shown as a risk factor for…”
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Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease by Sidhom, Eriene-Heidi, Kim, Choah, Kost-Alimova, Maria, Ting, May Theng, Keller, Keith, Avila-Pacheco, Julian, Watts, Andrew Jb, Vernon, Katherine A, Marshall, Jamie L, Reyes-Bricio, Estefanía, Racette, Matthew, Wieder, Nicolas, Kleiner, Giulio, Grinkevich, Elizabeth J, Chen, Fei, Weins, Astrid, Clish, Clary B, Shaw, Jillian L, Quinzii, Catarina M, Greka, Anna

“…Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney…”
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Acute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H–Related Protein 5 Deficiency by Vernon, Katherine A., MB, BS, Goicoechea de Jorge, Elena, PhD, Hall, Angela E., FIBMS, Fremeaux-Bacchi, Veronique, PhD, Aitman, Timothy J., FMedSci, Cook, H. Terence, FMedSci, Hangartner, Robert, FRCPath, Koziell, Ania, PhD, Pickering, Matthew C., PhD

“…Acute poststreptococcal glomerulonephritis is a common cause of acute nephritis in children. Transient hypocomplementemia and complete recovery are typical,…”
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Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency by RUSEVA, Marieta M, VERNON, Katherine A, LESHER, Allison M, SCHWAEBLE, Wilhelm J, ALI, Youssif M, BOTTO, Marina, COOK, Terence, WENCHAO SONG, STOVER, Cordula M, CALEB PICKERING, Matthew

“…Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator. CFH-deficient mice…”
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A hybrid CFHR3-1 gene causes familial C3 glomerulopathy by Malik, Talat H, Lavin, Peter J, Goicoechea de Jorge, Elena, Vernon, Katherine A, Rose, Kirsten L, Patel, Mitali P, de Leeuw, Marcel, Neary, John J, Conlon, Peter J, Winn, Michelle P, Pickering, Matthew C

“…Controlled activation of the complement system, a key component of innate immunity, enables destruction of pathogens with minimal damage to host tissue…”
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High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways by Marshall, Jamie L., Noel, Teia, Wang, Qingbo S., Chen, Haiqi, Murray, Evan, Subramanian, Ayshwarya, Vernon, Katherine A., Bazua-Valenti, Silvana, Liguori, Katie, Keller, Keith, Stickels, Robert R., McBean, Breanna, Heneghan, Rowan M., Weins, Astrid, Macosko, Evan Z., Chen, Fei, Greka, Anna

“…High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of…”
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Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy by Vernon, Katherine A, Ruseva, Marieta M, Cook, H Terence, Botto, Marina, Malik, Talat H, Pickering, Matthew C

“…The complement-mediated renal diseases C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) strongly associate with inherited and acquired…”
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Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution by Halawi, Ahmad, El Kurdi, Abdullah B, Vernon, Katherine A, Solhjou, Zhabiz, Choi, John Y, Saad, Anis J, Younis, Nour K, Elfekih, Rania, Mohammed, Mostafa Tawfeek, Deban, Christa A, Weins, Astrid, Abdi, Reza, Riella, Leonardo V, De Serres, Sasha A, Cravedi, Paolo, Greka, Anna, Khoueiry, Pierre, Azzi, Jamil R

“…Kidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were…”
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Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene by Westra, Dineke, Vernon, Katherine A, Volokhina, Elena B, Pickering, Matthew C, van de Kar, Nicole C A J, van den Heuvel, Lambert P

“…Atypical hemolytic uremic syndrome (aHUS) is a severe renal disorder that is associated with mutations in genes encoding proteins of the alternative complement…”
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Embolic Complications From Central Venous Hemodialysis Catheters Used With Hypertonic Citrate Locking Solution by Willicombe, Michelle Kay, MRCP, Vernon, Katherine, MRCP, Davenport, Andrew, MD

“…Many hemodialysis patients continue to dialyze using central venous access catheters in clinical practice. Catheters are associated with a number of recognized…”
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A Hybrid CFHR3-1 Gene Causes Familial C3 Glomerulopathy by MALIK, Talat H, LAVIN, Peter J, PICKERING, Matthew C, GOICOECHEA DE JORGE, Elena, VERNON, Katherine A, ROSE, Kirsten L, PATEL, Mitali P, DE LEEUW, Marcel, NEARLY, John J, COLON, Peter J, WINN, Michelle P

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Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury by Subramanian, Ayshwarya, Vernon, Katherine A., Zhou, Yiming, Marshall, Jamie L., Alimova, Maria, Arevalo, Carlos, Zhang, Fan, Slyper, Michal, Waldman, Julia, Montesinos, Monica S., Dionne, Danielle, Nguyen, Lan T., Cuoco, Michael S., Dubinsky, Dan, Purnell, Jason, Keller, Keith, Sturner, Samuel H., Grinkevich, Elizabeth, Ghoshal, Ayan, Kotek, Amanda, Trivioli, Giorgio, Richoz, Nathan, Humphrey, Mary B., Darby, Isabella G., Miller, Sarah J., Xu, Yingping, Weins, Astrid, Chloe-Villani, Alexandra, Chang, Steven L., Kretzler, Matthias, Rosenblatt-Rosen, Orit, Shaw, Jillian L., Zimmerman, Kurt A., Clatworthy, Menna R., Regev, Aviv, Greka, Anna

“…Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt…”
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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury by Kost-Alimova, Maria, Sidhom, Eriene-Heidi, Satyam, Abhigyan, Chamberlain, Brian T., Dvela-Levitt, Moran, Melanson, Michelle, Alper, Seth L., Santos, Jean, Gutierrez, Juan, Subramanian, Ayshwarya, Byrne, Patrick J., Grinkevich, Elizabeth, Reyes-Bricio, Estefanía, Kim, Choah, Clark, Abbe R., Watts, Andrew J.B., Thompson, Rebecca, Marshall, Jamie, Pablo, Juan Lorenzo, Coraor, Juliana, Roignot, Julie, Vernon, Katherine A., Keller, Keith, Campbell, Alissa, Emani, Maheswarareddy, Racette, Matthew, Bazua-Valenti, Silvana, Padovano, Valeria, Weins, Astrid, McAdoo, Stephen P., Tam, Frederick W.K., Ronco, Luciene, Wagner, Florence, Tsokos, George C., Shaw, Jillian L., Greka, Anna

“…Drug repurposing has the advantage of identifying potential treatments on a shortened timescale. In response to the pandemic spread of SARS-CoV-2, we took…”
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Improving the quality of trauma meetings by implementation of a modern trauma management platform by Sephton, Benjamin Michael, Vernon, Olivia Katherine, Kimber, Kathryn, Shenouda, Michael, Mahapatra, Piyush

“…Trauma meetings constitute the majority of clinical decision-making for new referrals and also act as a crucial tool to coordinate the trauma theatre list…”
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Properdin deficiency exacerbates C3 glomerulopathy in factor H-deficient mice by Ruseva, Marieta M, Vernon, Katherine A, Lesher, Allison M, Schwaeble, Wilhelm J, Ali, Youssif M, Botto, Marina, Cook, H.T, Song, Wen-Chao, Stover, Cordula M, Pickering, Matthew C

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Complement Activation-Related Pseudo-Allergy: A Fresh Look at Hypersensitivity Reactions to Intravenous Iron by Macdougall, Iain C, Vernon, Katherine

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Complement in Glomerular Disease by Vernon, Katherine A, Cook, H. Terence

“…The role of the complement system in renal disease has long been recognized, but there have been major advances in our understanding of its role over the past…”
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3186 INVESTIGATING TREM2 MACROPHAGES IN CHRONIC KIDNEY DISEASE by Trivioli, Giorgio, Richoz, Nathan, Subramanian, Ayshwarya, Vernon, Katherine, Trotter, Patrick, Zhou, Yiming, Shaw, Jillian, Greka, Anna, Clatworthy, Menna

“…Abstract Background and Aims Kidney macrophages have been implicated in interstitial fibrosis and inflammation in various forms of chronic kidney disease…”
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Experimental models of membranoproliferative glomerulonephritis, including dense deposit disease by Vernon, Katherine A, Pickering, Matthew C, Cook, Terence

“…Membranoproliferative glomerulonephritis (MPGN) is characterised by mesangial expansion and hypercellularity and capillary wall thickening with capillary wall…”
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