Search Results - "Vernet, Thierry"
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Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane
Published in The EMBO journal (20-04-2011)“…Bacterial cell growth necessitates synthesis of peptidoglycan. Assembly of this major constituent of the bacterial cell wall is a multistep process starting in…”
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2
On-chip microbial culture for the specific detection of very low levels of bacteria
Published in Lab on a chip (21-10-2013)“…Microbial culture continues to be the most common protocol for bacterial detection and identification in medicine and agronomics. Using this process may take…”
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3
New insights into histidine triad proteins: solution structure of a Streptococcus pneumoniae PhtD domain and zinc transfer to AdcAII
Published in PloS one (28-11-2013)“…Zinc (Zn(2+)) homeostasis is critical for pathogen host colonization and invasion. Polyhistidine triad (Pht) proteins, located at the surface of various…”
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4
Remodeling of the Z-Ring Nanostructure during the Streptococcus pneumoniae Cell Cycle Revealed by Photoactivated Localization Microscopy
Published in mBio (18-08-2015)“…Ovococci form a morphological group that includes several human pathogens (enterococci and streptococci). Their shape results from two modes of cell wall…”
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5
Heterologous expression of membrane proteins: choosing the appropriate host
Published in PloS one (21-12-2011)“…Membrane proteins are the targets of 50% of drugs, although they only represent 1% of total cellular proteins. The first major bottleneck on the route to their…”
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6
Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae
Published in PLoS pathogens (01-04-2022)“…Two-component regulatory systems (TCS) are among the most widespread mechanisms that bacteria use to sense and respond to environmental changes. In the human…”
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Structural Basis of Host Cell Recognition by the Pilus Adhesin from Streptococcus pneumoniae
Published in Structure (London) (13-01-2010)“…Pili are fibrous virulence factors associated directly to the bacterial surface that play critical roles in adhesion and recognition of host cell receptors…”
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Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan
Published in PloS one (30-04-2015)“…Release of conserved cytoplasmic proteins is widely spread among Gram-positive and Gram-negative bacteria. Because these proteins display additional functions…”
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9
Characterisation of the Effect of the Spatial Organisation of Hemicellulases on the Hydrolysis of Plant Biomass Polymer
Published in International journal of molecular sciences (19-06-2020)“…Synergism between enzymes is of crucial importance in cell metabolism. This synergism occurs often through a spatial organisation favouring proximity and…”
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The Interaction of Streptococcus pneumoniae with Plasmin Mediates Transmigration across Endothelial and Epithelial Monolayers by Intercellular Junction Cleavage
Published in Infection and Immunity (01-11-2008)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae
Published in ACS chemical biology (20-12-2013)“…Understanding the molecular basis of bacterial cell wall assembly is of paramount importance in addressing the threat of increasing antibiotic resistance…”
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Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition
Published in PloS one (02-12-2015)“…Understanding the relationship between protein sequence and molecular recognition selectivity remains a major challenge. The antibody fragment scFv1F4…”
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13
PatA and PatB Form a Functional Heterodimeric ABC Multidrug Efflux Transporter Responsible for the Resistance of Streptococcus pneumoniae to Fluoroquinolones
Published in Biochemistry (Easton) (02-10-2012)“…All bacterial multidrug ABC transporters have been shown to work as either homodimers or heterodimers. Two possibly linked genes, patA and patB from…”
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Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System
Published in mBio (31-03-2020)“…The capsule is the dominant virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected…”
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New adhesin functions of surface-exposed pneumococcal proteins
Published in BMC microbiology (12-07-2010)“…Streptococcus pneumoniae is a widely distributed commensal Gram-positive bacteria of the upper respiratory tract. Pneumococcal colonization can progress to…”
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Spatio-temporal based deep learning for rapid detection and identification of bacterial colonies through lens-free microscopy time-lapses
Published in PLOS digital health (01-10-2022)“…Detection and identification of pathogenic bacteria isolated from biological samples (blood, urine, sputum, etc.) are crucial steps in accelerated clinical…”
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The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae
Published in Scientific reports (15-05-2018)“…Bacterial division is intimately linked to synthesis and remodeling of the peptidoglycan, a cage-like polymer that surrounds the bacterial cell, providing…”
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18
Full-length structure of the major autolysin LytA
Published in Acta crystallographica. Section D, Biological crystallography. (01-06-2015)“…LytA is responsible for the autolysis of many Streptococcus species, including pathogens such as S. pneumoniae, S. pseudopneumoniae and S. mitis. However, how…”
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Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo
Published in PloS one (24-07-2012)“…Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens…”
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Sortase-Mediated Pilus Fiber Biogenesis in Streptococcus pneumoniae
Published in Structure (London) (10-12-2008)“…Streptococcus pneumoniae is a piliated pathogen whose ability to circumvent vaccination and antibiotic treatment strategies is a cause of mortality worldwide…”
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