Search Results - "Verner, Jan"

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells by Boudny, Miroslav, Zemanova, Jana, Khirsariya, Prashant, Borsky, Marek, Verner, Jan, Cerna, Jana, Oltova, Alexandra, Seda, Vaclav, Mraz, Marek, Jaros, Josef, Jaskova, Zuzana, Spunarova, Michaela, Brychtova, Yvona, Soucek, Karel, Drapela, Stanislav, Kasparkova, Marie, Mayer, Jiri, Paruch, Kamil, Trbusek, Martin

“…Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic…”
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The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration by KAUCKA, Markéta, PLEVOVA, Karla, TICHY, Boris, BRYCHTOVA, Yvona, DOUBEK, Michael, KOZUBIK, Alois, MAYER, Jiří, POSPISILOVA, Sarka, BRYJA, Vítĕzslav, PAVLOVA, Sarka, JANOVSKA, Pavlina, MISHRA, Archana, VERNER, Jan, PROCHAZKOVA, Jiřina, KREJCI, Pavel, KOTASKOVA, Jana, OVESNA, Petra

“…The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway…”
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Volatile organic compounds in motor vehicle interiors under various conditions and their effect on human health by VERNER, Jan, SEJKOROVÁ, Marie, VESELÍK, Petr

“…The aim of this paper is to estimate the mass concentrations of volatile organic compounds (VOCs) such as benzene (B), toluene (T), ethylbenzene (E) and m-,…”
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Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro by Ledererova, Aneta, Dostalova, Lenka, Kozlova, Veronika, Peschelova, Helena, Ladungova, Adriana, Culen, Martin, Loja, Tomas, Verner, Jan, Pospisilova, Sarka, Smida, Michal, Mancikova, Veronika

“…BackgroundAnti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce remissions in hemato-oncological patients with recurred and/or refractory…”
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Efficiency Assessment of Fuel Borne Catalyst by Sejkorová, Marie, Šarkan, Branislav, Verner, Jan

“…Fuel additives are offered to motorists at petrol stations and on the internet. Cerium or iron in the form of ferrocene is often used as a catalytically active…”
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Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia by Mancikova, Veronika, Peschelova, Helena, Kozlova, Veronika, Ledererova, Aneta, Ladungova, Adriana, Verner, Jan, Loja, Tomas, Folber, Frantisek, Mayer, Jiri, Pospisilova, Sarka, Smida, Michal

“…BackgroundWhile achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected…”
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PŘEHLED VÝVOJE EMISNÍCH STANDARDŮ PRO OMEZENÍ ZNEČIŠŤOVÁNÍ OVZDUŠÍ NESILNIČNÍMI MOBILNÍMI STROJI by Verner, Jan

“…Každý stroj poháněný spalovacím motorem má vliv na obecnou úroveň antropogenního znečištění. Tyto pohony podléhají různým předpisům omezujícím jejich emise pro…”
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PŘEHLED VÝVOJE EMISNÍCH STANDARDŮ PRO OMEZENÍ ZNEČIŠŤOVÁNÍ OVZDUŠÍ NESILNIČNÍMI MOBILNÍMI STROJI by Jan Verner

“…Každý stroj poháněný spalovacím motorem má vliv na obecnou úroveň antropogenního znečištění. Tyto pohony podléhají různým předpisům omezujícím jejich emise pro…”
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FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia by Seda, Vaclav, Vojackova, Eva, Ondrisova, Laura, Kostalova, Lenka, Sharma, Sonali, Loja, Tomas, Mladonicka Pavlasova, Gabriela, Zicha, Daniel, Kudlickova Peskova, Marie, Krivanek, Jan, Liskova, Kvetoslava, Kren, Leos, Benes, Vladimir, Musilova Litzmanova, Katerina, Borsky, Marek, Oppelt, Jan, Verner, Jan, Pospisilova, Sarka, Brychtova, Yvona, Panovska, Anna, Tan, Zhi, Zhang, Shuxing, Doubek, Michael, Amruz Cerna, Katerina, Mayer, Jiri, Mraz, Marek

“…Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and lymphoid niches plays a critical role in disease pathophysiology,…”
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Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs by Hoferkova, Eva, Seda, Vaclav, Kadakova, Sona, Verner, Jan, Loja, Tomas, Matulova, Kvetoslava, Skuhrova Francova, Hana, Ondrouskova, Eva, Filip, Daniel, Blavet, Nicolas, Boudny, Miroslav, Mladonicka Pavlasova, Gabriela, Vecera, Josef, Ondrisova, Laura, Pavelkova, Petra, Hlavac, Krystof, Kostalova, Lenka, Michaelou, Androniki, Pospisilova, Sarka, Dorazilova, Jana, Chochola, Vaclav, Jaros, Josef, Doubek, Michael, Jarosova, Marie, Hampl, Ales, Vojtova, Lucy, Kren, Leos, Mayer, Jiri, Mraz, Marek

“…Several in vitro models have been developed to mimic chronic lymphocytic leukemia (CLL) proliferation in immune niches; however, they typically do not induce…”
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Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia by Janovska, Pavlina, Verner, Jan, Kohoutek, Jiri, Bryjova, Lenka, Gregorova, Michaela, Dzimkova, Marta, Skabrahova, Hana, Radaszkiewicz, Tomasz, Ovesna, Petra, Vondalova Blanarova, Olga, Nemcova, Tereza, Hoferova, Zuzana, Vasickova, Katerina, Smyckova, Lucie, Egle, Alexander, Pavlova, Sarka, Poppova, Lucie, Plevova, Karla, Pospisilova, Sarka, Bryja, Vitezslav

“…Casein kinase 1δ/ε (CK1δ/ε) is a key component of noncanonical Wnt signaling pathways, which were shown previously to drive pathogenesis of chronic lymphocytic…”
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MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia by Mraz, Marek, Dolezalova, Dasa, Plevova, Karla, Stano Kozubik, Katerina, Mayerova, Veronika, Cerna, Katerina, Musilova, Katerina, Tichy, Boris, Pavlova, Sarka, Borsky, Marek, Verner, Jan, Doubek, Michael, Brychtova, Yvona, Trbusek, Martin, Hampl, Ales, Mayer, Jiri, Pospisilova, Sarka

“…MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap…”
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Transcription factor c-Myb: novel prognostic factor in osteosarcoma by Říhová, Kamila, Dúcka, Monika, Zambo, Iva Staniczková, Vymětalová, Ladislava, Šrámek, Martin, Trčka, Filip, Verner, Jan, Drápela, Stanislav, Fedr, Radek, Suchánková, Tereza, Pavlatovská, Barbora, Ondroušková, Eva, Kubelková, Irena, Zapletalová, Danica, Tuček, Štěpán, Múdry, Peter, Krákorová, Dagmar Adámková, Knopfová, Lucia, Šmarda, Jan, Souček, Karel, Borsig, Lubor, Beneš, Petr

“…The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival when aberrantly activated/expressed, thus contributing to malignant…”
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Human Embryonic Stem Cells Are Capable of Executing G1/S Checkpoint Activation by Bárta, Tomáš, Vinarský, Vladimír, Holubcová, Zuzana, Doležalová, Dáša, Verner, Jan, Pospíšilová, Šárka, Dvořák, Petr, Hampl, Aleš

“…Embryonic stem cells progress very rapidly through the cell cycle, allowing limited time for cell cycle regulatory circuits that typically function in somatic…”
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Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells by Zemanova, Jana, Hylse, Ondrej, Collakova, Jana, Vesely, Pavel, Oltova, Alexandra, Borsky, Marek, Zaprazna, Kristina, Kasparkova, Marie, Janovska, Pavlina, Verner, Jan, Kohoutek, Jiri, Dzimkova, Marta, Bryja, Vitezslav, Jaskova, Zuzana, Brychtova, Yvona, Paruch, Kamil, Trbusek, Martin

“…Treatment options for TP53-mutated lymphoid tumors are very limited. In experimental models, TP53-mutated lymphomas were sensitive to direct inhibition of…”
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NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines by Verner, Jan, Trbusek, Martin, Chovancova, Jana, Jaskova, Zuzana, Moulis, Mojmir, Folber, Frantisek, Halouzka, Roman, Mayer, Jiri, Pospisilova, Sarka, Doubek, Michael

“…Xenograft models represent a promising tool to study the pathogenesis of hematological malignancies. To establish a reliable and appropriate in vivo model of…”
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Gene-Expression Profile of Steroid-Refractory Acute Graft-Versus-Host Disease by Verner, Jan, Kabathova, Jitka, Zdrahal, Zbynek, Tomancova, Alexandra, Volejnikova, Jana, Brychtova, Yvona, Pospisilova, Sarka, Mayer, Jiri

“…Abstract 4549 Steroid-refractory acute graft-versus-host disease (aGVHD) remains to be the major complication of allogeneic hematopoietic stem cells…”
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Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation by Verner, Jan, Kabathova, Jitka, Tomancova, Alexandra, Pavlova, Sarka, Tichy, Boris, Mraz, Marek, Brychtova, Yvona, Krejci, Marta, Zdrahal, Zbynek, Trbusek, Martin, Volejnikova, Jana, Sedlacek, Petr, Doubek, Michael, Mayer, Jiri, Pospisilova, Sarka

“…Acute graft-vs-host disease (aGVHD) is a frequent, life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Despite…”
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Gene-Expression Profiling of Graft-Versus-Host Disease by Oligonucleotide Microarrays by Verner, Jan, Kabathova, Jitka, Tichy, Boris, Zdrahal, Zbynek, Tomancova, Alexandra, Brychtova, Yvona, Doubek, Michael, Mraz, Marek, Malcikova, Jitka, Pospisilova, Sarka, Mayer, Jiri

“…Abstract 4645 Graft-versus-host disease (GvHD) is the life-threatening complication of allogeneic hematopoietic stem cells transplantation (allo-HSCT). GvHD is…”
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Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients by Mraz, Marek, Malinova, Karla, Pavlova, Sarka, Tichy, Boris, Kozubik, Katerina Stano, Malcikova, Jitka, Borsky, Marek, Verner, Jan, Doubek, Michael, Brychtova, Yvona, Trbusek, Martin, Mayer, Jiri, Pospisilova, Sarka

“…Abstract 1231 Poster Board I-253 Chromosomal abnormalities are present in the majority of CLL cases (>80%) and recently, a novel deletion of 22q11 was…”
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