Search Results - "Vernall, Andrea J."

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses by Lamichhane, Rajesh, Schneider, Marion, de la Harpe, Sara M., Harrop, Thomas W.R., Hannaway, Rachel F., Dearden, Peter K., Kirman, Joanna R., Tyndall, Joel D.A., Vernall, Andrea J., Ussher, James E.

“…Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from…”
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Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias by Sharma, Raahul, Singh, Sameek, Whiting, Zak M, Molitor, Maximilian, Vernall, Andrea J, Grimsey, Natasha L

“…Cannabinoid Receptor 2 (CB2) is a promising target for treating inflammatory diseases. We designed derivatives of 3-carbamoyl-2-pyridone and…”
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Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells by Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

“…The histamine H 1 -receptor (H 1 R) is an important mediator of allergy and inflammation. H 1 R antagonists have particular clinical utility in allergic…”
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Editorial: Therapeutic potential of the cannabinoid CB2 receptor by Smoum, Reem, Grether, Uwe, Karsak, Meliha, Vernall, Andrea J., Park, Frank, Hillard, Cecilia J., Pacher, Pal

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Characterisation of AMB-FUBINACA metabolism and CB1-mediated activity of its acid metabolite by Webb, Hunter D. J., Finlay, David B., Chen, Shuli, Vernall, Andrea J., Sparkes, Eric, Banister, Samuel D., Rosengren, Rhonda J., Glass, Michelle

“…Purpose AMB-FUBINACA is a synthetic cannabinoid receptor agonist (SCRA) which is primarily metabolised by hepatic enzymes producing AMB-FUBINACA carboxylic…”
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Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines by Oyagawa, Caitlin R M, de la Harpe, Sara M, Saroz, Yurii, Glass, Michelle, Vernall, Andrea J, Grimsey, Natasha Lillia

“…Cannabinoid receptor 2 (CB ) is predominantly distributed in immune tissues and cells and is a promising therapeutic target for modulating inflammation. In…”
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Single α-Helical Turn Stabilized by Replacement of an Internal Hydrogen Bond with a Covalent Ethylene Bridge by Vernall, Andrea J, Cassidy, Peter, Alewood, Paul F

“…Walking the carbon bridge to helix stabilization: α‐Helix mimetics have been synthesized that contain an ethylene linkage in place of an (i,i+4) hydrogen bond…”
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The evolving small‐molecule fluorescent‐conjugate toolbox for Class A GPCRs by Vernall, Andrea J, Hill, Stephen J, Kellam, Barrie

“…The past decade has witnessed fluorescently tagged drug molecules gaining significant attraction in their use as pharmacological tools with which to visualize…”
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Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future by Whiting, Zak M., Yin, Jiazhen, de la Harpe, Sara M., Vernall, Andrea J., Grimsey, Natasha L.

“…Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical…”
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Type I interferons are important co‐stimulatory signals during T cell receptor mediated human MAIT cell activation by Lamichhane, Rajesh, Galvin, Henry, Hannaway, Rachel F, la Harpe, Sara M, Munro, Fran, Tyndall, Joel DA, Vernall, Andrea J, McCall, John L, Husain, Matloob, Ussher, James E

“…Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that can be stimulated either via their TCR or by innate cytokines. The MAIT…”
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Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors by Cooper, Anna, Singh, Sameek, Hook, Sarah, Tyndall, Joel D A, Vernall, Andrea J

“…Cannabinoid, free fatty acid, lysophosphatidic acid, sphingosine 1-phosphate, prostanoid, leukotriene, bile acid, and platelet-activating factor receptor…”
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Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation by Lamichhane, Rajesh, Munro, Fran, Harrop, Thomas W. R., Harpe, Sara M., Dearden, Peter K., Vernall, Andrea J., McCall, John L, Ussher, James E.

“…Mucosal associated invariant T (MAIT) cells are anti‐microbial innate‐like T cells that are abundant in blood and liver. MAIT cells express a semi‐invariant…”
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Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor by Payne, China M., Baltos, Jo‐Anne, Langiu, Monica, Sinh Lu, Cam, Tyndall, Joel D. A., Gregory, Karen J., May, Lauren T., Vernall, Andrea J.

“…Accumulating evidence suggests that G protein‐coupled receptors (GPCRs) can exist and function in homodimer and heterodimer forms. The adenosine A1 receptor…”
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To prohibit or regulate psychoactive substances: has New Zealand got the right approach? by Rizwan, Shakila B, Vernall, Andrea J

“…Prohibition of a continuous stream of new psychoactive substances is both difficult and costly Shakila Rizwan and Andrea Vernall look at New Zealand’s attempt…”
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Development of Covalent, Clickable Probes for Adenosine A1 and A3 Receptors by Trinh, Phuc N. H, Chong, Daniel J. W, Leach, Katie, Hill, Stephen J, Tyndall, Joel D. A, May, Lauren T, Vernall, Andrea J, Gregory, Karen J

“…Adenosine receptors are attractive therapeutic targets for multiple conditions, including ischemia-reperfusion injury and neuropathic pain. Adenosine receptor…”
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Covalent Isothiocyanate Inhibitors of Macrophage Migration Inhibitory Factor as Potential Colorectal Cancer Treatments by Putha, Lohitha, Kok, Liang K., Fellner, Matthias, Rutledge, Malcolm T., Gamble, Allan B., Wilbanks, Sigurd M., Vernall, Andrea J., Tyndall, Joel D. A.

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that has roles in innate and adaptive human immune responses, as well as…”
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Neutrophils suppress mucosal‐associated invariant T cells in humans by Schneider, Marion, Hannaway, Rachel F., Lamichhane, Rajesh, Harpe, Sara M., Tyndall, Joel D.A., Vernall, Andrea J., Kettle, Anthony J., Ussher, James E.

“…Mucosal‐associated invariant T (MAIT) cells are innate‐like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to…”
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Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist by Stoddart, Leigh A., Vernall, Andrea J., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

“…Fluorescence based probes provide a novel way to study the dynamic internalization process of G protein-coupled receptors (GPCRs). Recent advances in the…”
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Development of Chromenopyrazole-Based Selective Cannabinoid 2 Receptor Agonists by Singh, Sameek, Liddle, Ian, Macdonald, Christa, Tyndall, Joel D A, Glass, Michelle, Vernall, Andrea J

“…The cannabinoid type 2 receptor (CB2R) is an important therapeutic target for pain and inflammatory disorders. G protein-coupled receptors (GPCRs) are…”
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Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment by Cooper, Anna G., MacDonald, Christa, Glass, Michelle, Hook, Sarah, Tyndall, Joel D.A., Vernall, Andrea J.

“…Cannabinoid type 2 (CB2) receptor continues to emerge as a promising drug target for many diseases and conditions. New tools for studying CB2 receptor are…”
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