Search Results - "Vermillion, Meghan S."

Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes by Vermillion, Meghan S., Lei, Jun, Shabi, Yahya, Baxter, Victoria K., Crilly, Nathan P., McLane, Michael, Griffin, Diane E., Pekosz, Andrew, Klein, Sabra L., Burd, Irina

“…Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall…”
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Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females by Hall, Olivia J, Limjunyawong, Nathachit, Vermillion, Meghan S, Robinson, Dionne P, Wohlgemuth, Nicholas, Pekosz, Andrew, Mitzner, Wayne, Klein, Sabra L

“…Over 100 million women use progesterone therapies worldwide. Despite having immunomodulatory and repair properties, their effects on the outcome of viral…”
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Progesterone-Based Contraceptives Reduce Adaptive Immune Responses and Protection against Sequential Influenza A Virus Infections by Hall, Olivia J, Nachbagauer, Raffael, Vermillion, Meghan S, Fink, Ashley L, Phuong, Vanessa, Krammer, Florian, Klein, Sabra L

“…In addition to their intended use, progesterone (P4)-based contraceptives promote anti-inflammatory immune responses, yet their effects on the outcome of…”
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Head Kinematics, Blood Biomarkers, and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock by Mayer, Andrew R, Dodd, Andrew B, Dodd, Rebecca J, Stephenson, David D, Ling, Josef M, Mehos, Carissa J, Patton, Declan A, Robertson-Benta, Cidney R, Gigliotti, Andrew P, Vermillion, Meghan S, Noghero, Alessio

“…Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) are each leading causes of mortality and morbidity worldwide, and…”
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17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial by Mayer, Andrew R, Dodd, Andrew B, Rannou-Latella, Julie G, Stephenson, David D, Dodd, Rebecca J, Ling, Josef M, Mehos, Carissa J, Robertson-Benta, Cidney R, Pabbathi Reddy, Sharvani, Kinsler, Rachel E, Vermillion, Meghan S, Gigliotti, Andrew P, Sicard, Veronik, Lloyd, Amy L, Erhardt, Erik B, Gill, Jessica M, Lai, Chen, Guedes, Vivian A, Chaudry, Irshad H

“…Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when…”
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Effect of TRPV4 Antagonist GSK2798745 on Chlorine Gas-Induced Acute Lung Injury in a Swine Model by Vermillion, Meghan S, Saari, Nathan, Bray, Mathieu, Nelson, Andrew M, Bullard, Robert L, Rudolph, Karin, Gigliotti, Andrew P, Brendler, Jeffrey, Jantzi, Jacob, Kuehl, Philip J, McDonald, Jacob D, Burgert, Mark E, Weber, Waylon, Sucoloski, Scott, Behm, David J

“…As a regulator of alveolo-capillary barrier integrity, Transient Receptor Potential Vanilloid 4 (TRPV4) antagonism represents a promising strategy for reducing…”
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Production of amphiregulin and recovery from influenza is greater in males than females by Vermillion, Meghan S, Ursin, Rebecca L, Kuok, Denise I T, Vom Steeg, Landon G, Wohlgemuth, Nicholas, Hall, Olivia J, Fink, Ashley L, Sasse, Eric, Nelson, Andrew, Ndeh, Roland, McGrath-Morrow, Sharon, Mitzner, Wayne, Chan, Michael C W, Pekosz, Andrew, Klein, Sabra L

“…Amphiregulin (AREG) is an epidermal growth factor that is a significant mediator of tissue repair at mucosal sites, including in the lungs during influenza A…”
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Reproducibility and Characterization of Head Kinematics During a Large Animal Acceleration Model of Traumatic Brain Injury by Mayer, Andrew R, Ling, Josef M, Dodd, Andrew B, Rannou-Latella, Julie G, Stephenson, David D, Dodd, Rebecca J, Mehos, Carissa J, Patton, Declan A, Cullen, D Kacy, Johnson, Victoria E, Pabbathi Reddy, Sharvani, Robertson-Benta, Cidney R, Gigliotti, Andrew P, Meier, Timothy B, Vermillion, Meghan S, Smith, Douglas H, Kinsler, Rachel

“…Acceleration parameters have been utilized for the last six decades to investigate pathology in both human and animal models of traumatic brain injury (TBI),…”
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Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza by Vermillion, Meghan S, Ursin, Rebecca L, Attreed, Sarah E, Klein, Sabra L

“…Abstract Estriol (E3) is an endogenous estrogen in females with broad biological activity within diverse tissue types. In the context of certain…”
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Age and testosterone mediate influenza pathogenesis in male mice by Vom Steeg, Landon G, Vermillion, Meghan S, Hall, Olivia J, Alam, Ornob, McFarland, Ross, Chen, Haolin, Zirkin, Barry, Klein, Sabra L

“…Influenza severity increases with age, with hospitalization and mortality rates during seasonal influenza epidemics being higher in older men than age-matched…”
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Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection by Vermillion, Meghan S, Murakami, Eisuke, Ma, Bin, Pitts, Jared, Tomkinson, Adrian, Rautiola, Davin, Babusis, Darius, Irshad, Hammad, Seigel, Dustin, Kim, Cynthia, Zhao, Xiaofeng, Niu, Congrong, Yang, Jesse, Gigliotti, Andrew, Kadrichu, Nani, Bilello, John P, Ellis, Scott, Bannister, Roy, Subramanian, Raju, Smith, Bill, Mackman, Richard L, Lee, William A, Kuehl, Philip J, Hartke, Jim, Cihlar, Tomas, Porter, Danielle P

“…Remdesivir (RDV) is a nucleotide analog prodrug with demonstrated clinical benefit in patients with coronavirus disease 2019 (COVID-19). In October 2020, the…”
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Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females by Potluri, Tanvi, Fink, Ashley L., Sylvia, Kristyn E., Dhakal, Santosh, Vermillion, Meghan S., vom Steeg, Landon, Deshpande, Sharvari, Narasimhan, Harish, Klein, Sabra L.

“…Vaccine-induced immunity declines with age, which may differ between males and females. Using human sera collected before and 21 days after receipt of the…”
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Animal Models of Enterovirus D68 Infection and Disease by Vermillion, Meghan S., Dearing, Justin, Zhang, Yun, Adney, Danielle R., Scheuermann, Richard H., Pekosz, Andrew, Tarbet, E. Bart

“…Human enterovirus D68 (EV-D68) is a globally reemerging respiratory pathogen that is associated with the development of acute flaccid myelitis (AFM) in…”
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Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus by Cross, Robert W, Woolsey, Courtney, Chu, Victor C, Babusis, Darius, Bannister, Roy, Vermillion, Meghan S, Geleziunas, Romas, Barrett, Kimberly T, Bunyan, Elaine, Nguyen, Anh-Quan, Cihlar, Tomas, Porter, Danielle P, Prasad, Abhishek N, Deer, Daniel J, Borisevich, Viktoriya, Agans, Krystle N, Martinez, Jasmine, Harrison, Mack B, Dobias, Natalie S, Fenton, Karla A, Bilello, John P, Geisbert, Thomas W

“…Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19…”
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Pregnancy and infection: using disease pathogenesis to inform vaccine strategy by Vermillion, Meghan S., Klein, Sabra L.

“…Vaccination is the mainstay of preventative medicine for many infectious diseases. Pregnant women, unborn fetuses, and neonates represent three at-risk…”
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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection by Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has infected over 260 million people over the past…”
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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys by Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.

“…Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research…”
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A systematic review of large animal models of combined traumatic brain injury and hemorrhagic shock by Mayer, Andrew R., Dodd, Andrew B., Vermillion, Meghan S., Stephenson, David D., Chaudry, Irshad H., Bragin, Denis E., Gigliotti, Andrew P., Dodd, Rebecca J., Wasserott, Benjamin C., Shukla, Priyank, Kinsler, Rachel, Alonzo, Sheila M.

“…•The majority of combined poly-neurotrauma models target 35–45% blood loss.•CCI and FPI are currently the only two TBI methods used in combined models.•Common…”
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A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads by Pate, Kelly A. Metcalf, Pohlmeyer, Christopher W., Walker-Sperling, Victoria E., Foote, Jeremy B., Najarro, Kevin M., Cryer, Catherine G., Salgado, Maria, Gama, Lucio, Engle, Elizabeth L., Shirk, Erin N., Queen, Suzanne E., Chioma, Stanley, Vermillion, Meghan S., Bullock, Brandon, Li, Ming, Lyons, Claire E., Adams, Robert J., Zink, M. Christine, Clements, Janice E., Mankowski, Joseph L., Blankson, Joel N.

“…Background. Sensitive assays are needed for detection of residual human immunodeficiency virus (HIV) in patients with undetectable plasma viral loads to…”
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Survival Rates and Biomarkers in a Large Animal Model of Traumatic Brain Injury Combined With Two Different Levels of Blood Loss by Mayer, Andrew R., Dodd, Andrew B., Ling, Josef M., Stephenson, David D., Rannou-Latella, Julie G., Vermillion, Meghan S., Mehos, Carissa J., Johnson, Victoria E., Gigliotti, Andrew P., Dodd, Rebecca J., Chaudry, Irshad H., Meier, Timothy B., Smith, Douglas H., Bragin, Denis E., Lai, Chen, Wagner, Chelsea L., Guedes, Vivian A., Gill, Jessica M., Kinsler, Rachel

“…INTRODUCTION:The pathology resulting from concurrent traumatic brain injury (TBI) and hemorrhagic shock (HS; TBI+HS) are leading causes of mortality and…”
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