Search Results - "Vermeulen, Wim"

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins by Kumar, Namrata, Theil, Arjan F., Roginskaya, Vera, Ali, Yasmin, Calderon, Michael, Watkins, Simon C., Barnes, Ryan P., Opresko, Patricia L., Pines, Alex, Lans, Hannes, Vermeulen, Wim, Van Houten, Bennett

“…UV-DDB, consisting of subunits DDB1 and DDB2, recognizes UV-induced photoproducts during global genome nucleotide excision repair (GG-NER). We recently…”
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XPG: a multitasking genome caretaker by Muniesa-Vargas, Alba, Theil, Arjan F., Ribeiro-Silva, Cristina, Vermeulen, Wim, Lans, Hannes

“…The XPG/ERCC5 endonuclease was originally identified as the causative gene for Xeroderma Pigmentosum complementation group G. Ever since its discovery, in…”
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Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage by Slyskova, Jana, Sabatella, Mariangela, Ribeiro-Silva, Cristina, Stok, Colin, Theil, Arjan F, Vermeulen, Wim, Lans, Hannes

“…Abstract Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent determined by activity of the DNA damage response (DDR)…”
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Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir by Horváth, András, Depré, Dominique, Vermeulen, Wim A. A, Wuyts, Stijn L, Harutyunyan, Syuzanna R, Binot, Grégori, Cuypers, Jef, Couck, Wouter, Den Heuvel, Dirk Van

“…The key macrocyclization step in the synthesis of simeprevir, a hepatitis C virus (HCV) antiviral drug, was studied. N-Boc substitution on the diene precursor…”
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Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair by Ribeiro-Silva, Cristina, Sabatella, Mariangela, Helfricht, Angela, Marteijn, Jurgen A., Theil, Arjan F., Vermeulen, Wim, Lans, Hannes

“…DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC…”
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Neuroanatomy of lower gastrointestinal pain disorders by Vermeulen, Wim, De Man, Joris G, Pelckmans, Paul A, De Winter, Benedicte Y

“…Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the…”
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ATP-dependent chromatin remodeling in the DNA-damage response by Lans, Hannes, Marteijn, Jurgen A, Vermeulen, Wim

“…The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base…”
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Origin of the E/Z Selectivity in the Synthesis of Tetrasubstituted Olefins by Wittig Reaction of α‑Fluorophosphonium Ylides: An Explanation for the Low Stereoselectivity Observed in Reactions of α‑Alkoxy Aldehydes by Depré, Dominique, Vermeulen, Wim A. A, Lang, Yolande, Dubois, Jean, Vandevivere, Jan, Vandermeersch, Jeremy, Huang, Longchuan, Robiette, Raphaël

“…A series of tetrasubstituted fluoroalkenes were synthesized in good yield and high E/Z selectivity (up to 96/4) by Wittig reaction between α-heterosubstituted…”
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ERCC1–XPF targeting to psoralen–DNA crosslinks depends on XPA and FANCD2 by Sabatella, Mariangela, Pines, Alex, Slyskova, Jana, Vermeulen, Wim, Lans, Hannes

“…The effectiveness of many DNA-damaging chemotherapeutic drugs depends on their ability to form monoadducts, intrastrand crosslinks and/or interstrand…”
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The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage by Menoni, Hervé, Wienholz, Franziska, Theil, Arjan F, Janssens, Roel C, Lans, Hannes, Campalans, Anna, Radicella, J Pablo, Marteijn, Jurgen A, Vermeulen, Wim

“…Abstract Transcription-coupled nucleotide excision repair factor Cockayne syndrome protein B (CSB) was suggested to function in the repair of oxidative DNA…”
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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1 by Sabatella, Mariangela, Thijssen, Karen L., Davó-Martínez, Carlota, Vermeulen, Wim, Lans, Hannes

“…Hereditary DNA repair defects affect tissues differently, suggesting that in vivo cells respond differently to DNA damage. Knowledge of the DNA damage…”
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PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1 by Pines, Alex, Vrouwe, Mischa G, Marteijn, Jurgen A, Typas, Dimitris, Luijsterburg, Martijn S, Cansoy, Medine, Hensbergen, Paul, Deelder, André, de Groot, Anton, Matsumoto, Syota, Sugasawa, Kaoru, Thoma, Nicolas, Vermeulen, Wim, Vrieling, Harry, Mullenders, Leon

“…The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision…”
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Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair by Campalans, Anna, Kortulewski, Thierry, Amouroux, Rachel, Menoni, Hervé, Vermeulen, Wim, Radicella, J Pablo

“…Single-strand break repair (SSBR) and base excision repair (BER) of modified bases and abasic sites share several players. Among them is XRCC1, an essential…”
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Efficacy of a Cell-Culture–Derived Quadrivalent Influenza Vaccine in Children by Nolan, Terence, Fortanier, Alexandre C, Leav, Brett, Põder, Airi, Bravo, Lulu C, Szymański, Henryk T, Heeringa, Marten, Vermeulen, Wim, Matassa, Vince, Smolenov, Igor, Edelman, Jonathan M

“…There is a need for improved production of the influenza vaccine, including a shorter time from antigen identification to vaccine availability and minimization…”
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Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo by Menoni, Hervé, Hoeijmakers, Jan H J, Vermeulen, Wim

“…Base excision repair (BER) is the main repair pathway to eliminate abundant oxidative DNA lesions such as 8-oxo-7,8-dihydroguanine. Recent data suggest that…”
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SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair by van Cuijk, Loes, van Belle, Gijsbert J., Turkyilmaz, Yasemin, Poulsen, Sara L., Janssens, Roel C., Theil, Arjan F., Sabatella, Mariangela, Lans, Hannes, Mailand, Niels, Houtsmuller, Adriaan B., Vermeulen, Wim, Marteijn, Jurgen A.

“…XPC recognizes UV-induced DNA lesions and initiates their removal by nucleotide excision repair (NER). Damage recognition in NER is tightly controlled by…”
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Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling by Smeenk, Godelieve, Wiegant, Wouter W, Marteijn, Jurgen A, Luijsterburg, Martijn S, Sroczynski, Nicholas, Costelloe, Thomas, Romeijn, Ron J, Pastink, Albert, Mailand, Niels, Vermeulen, Wim, van Attikum, Haico

“…Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) arising in native chromatin elicit an RNF8/RNF168-dependent ubiquitylation response, which…”
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Global Regulation of Promoter Melting in Naive Lymphocytes by Kouzine, Fedor, Wojtowicz, Damian, Yamane, Arito, Resch, Wolfgang, Kieffer-Kwon, Kyong-Rim, Bandle, Russell, Nelson, Steevenson, Nakahashi, Hirotaka, Awasthi, Parirokh, Feigenbaum, Lionel, Menoni, Herve, Hoeijmakers, Jan, Vermeulen, Wim, Ge, Hui, Przytycka, Teresa M., Levens, David, Casellas, Rafael

“…Lymphocyte activation is initiated by a global increase in messenger RNA synthesis. However, the mechanisms driving transcriptome amplification during the…”
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DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1 by Ribeiro-Silva, Cristina, Aydin, Özge Z., Mesquita-Ribeiro, Raquel, Slyskova, Jana, Helfricht, Angela, Marteijn, Jurgen A., Hoeijmakers, Jan H. J., Lans, Hannes, Vermeulen, Wim

“…Mutations in SWI/SNF genes are amongst the most common across all human cancers, but efficient therapeutic approaches that exploit vulnerabilities caused by…”
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Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure by Muniesa-Vargas, Alba, Davó-Martínez, Carlota, Ribeiro-Silva, Cristina, van der Woude, Melanie, Thijssen, Karen L., Haspels, Ben, Häckes, David, Kaynak, Ülkem U., Kanaar, Roland, Marteijn, Jurgen A., Theil, Arjan F., Kuijten, Maayke M. P., Vermeulen, Wim, Lans, Hannes

“…Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the…”
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