Search Results - "Vermeulen, Nicolaas M. J."

Sensitive Detection Assays for Influenza RNA Do Not Reveal Viremia in US Blood Donors by Stramer, Susan L., Collins, Cynthia, Nugent, Thomas, Wang, Xue, Fuschino, Meghan, Heitman, John W., Law, Jacqueline, Krysztof, David E., Kiely, Nancy, Todd, Deborah, Vermeulen, Nicolaas M. J., Harrington, Karen, Kamel, Hany, Kelvin, David J., Busch, Michael P., St. George, Kirsten, Hewlett, Indira K., Linnen, Jeffrey M., Norris, Philip J.

“…Background. There have been anecdotal reports of influenza viremia since the 1960s. We present an assessment of the prevalence of seasonal and 2009 H1N1…”
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novel endonuclease IV post-PCR genotyping system by Kutyavin, Igor V, Milesi, Dave, Belousov, Yevgeniy, Podyminogin, Mikhail, Vorobiev, Alexei, Gorn, Vladimir, Lukhtanov, Eugeny A, Vermeulen, Nicolaas M.J, Mahoney, Walt

“…Here we describe a novel endonuclease IV (Endo IV) based assay utilizing a substrate that mimics the abasic lesions that normally occur in double-stranded DNA…”
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Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse Probe System in challenging sequence environment by Belousov, Yevgeniy S, Welch, Robert A, Sanders, Silvia, Mills, Alan, Kulchenko, Alena, Dempcy, Robert, Afonina, Irina A, Walburger, David K, Glaser, Cynthia L, Yadavalli, Sunita, Vermeulen, Nicolaas M J, Mahoney, Walt

“…Probe and primer design for single nucleotide polymorphism (SNP) detection can be very challenging for A-T DNA-rich targets, requiring long sequences with…”
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Reduced aggregation and improved specificity of G‐rich oligodeoxyribonucleotides containing pyrazolo[3,4‐d]pyrimidine guanine bases by Kutyavin, Igor V., Lokhov, Sergey G., Afonina, Irina A., Dempcy, Robert, Gall, Alexander A., Gorn, Vladimir V., Lukhtanov, Eugene, Metcalf, Mark, Mills, Alan, Reed, Michael W., Sanders, Sylvia, Shishkina, Irina, Vermeulen, Nicolaas M. J.

“…Guanine (G)‐rich oligodeoxyribonucleotides (ODNs) can form undesired complexes by self association through non‐Watson–Crick interactions. These aggregates can…”
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Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors by Graminski, Gerard F., Carlson, C.Lance, Ziemer, Josh R., Cai, Feng, Vermeulen, Nicolaas M.J., Vanderwerf, Scott M., Burns, Mark R.

“…A series of novel spermine dimer analogues was synthesized and assessed for their ability to inhibit spermidine transport into MDA-MB-231 breast carcinoma…”
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Improved biplex quantitative real-time polymerase chain reaction with modified primers for gene expression analysis by Afonina, Irina A, Mills, Alan, Sanders, Silvia, Kulchenko, Alena, Dempcy, Robert, Lokhov, Sergey, Vermeulen, Nicolaas M J, Mahoney, Walt

“…Stabilizing modified bases incorporated in primers allows the reduction of housekeeping gene primer concentration not possible with regular primers without…”
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Isolation of a neurotoxin from the salivary glands of female Rhipicephalus evertsi evertsi by Viljoen, G.J, Bezuidenhout, J.D, Oberem, P.T, Vermeulen, N.M.J, Visser, L, Gothe, R, Neitz, A.W.H

“…A quantitative study of the changes in the protein pattern of the salivary glands of female Rhipicephalus evertsi evertsi during the entire repletion process…”
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Irreversible enzyme inhibitors. CLXXV. Irreversible inhibition of purifed dihydrofolic reductase by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLVII. Effect of bridge modification on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-[m-(fluorosulfonyl)benzamidomethyl]phenoxymethyl]pyrimidine. I by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLVIII. Effect of bridge modification on the selective irreversible inhibition of a dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-[m-(fluorosulfonyl)benzamidomethyl]phenoxymethyl]pyrimidine. II by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-[p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido]-o-toluenesulfonyl fluoride (NSC-113423), and active-site-directed irreversible inhibitor of dihydrofolic reductase by Baker, Bernard Randall, Ryan, Adrian J, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CXXXVIII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with a terminal sulfonyl fluoride by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CXXXV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(p-fluorosulfonylphenylureido)phenoxymethyl]pyrimidine by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLXXIII. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihydrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine by Baker, Bernard Randall, Vermeulen, Nicolaas M. J, Ashton, Wallace T, Ryan, Adrian J

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Irreversible enzyme inhibitors. CLXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with 6 substituents and some factors in their cell wall transport by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CLXVIII. Irreversible inhibition of dihydrofolate reductase and cell wall transport by pyrimidines and dihydro-s-triazines with pyridinium side chains by Baker, Bernard Randall, Vermeulen, Nicolaas M. J, Ryan, Adrian J

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Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity by Baker, Bernard Randall, Vermeulen, Nicolaas M. J

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Irreversible enzyme inhibitors. CXXXIII. Differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse by Baker, Bernard Randall, Lourens, Gerhardus J, Meyer, Rich B, Vermeulen, Nicolaas M. J

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